Neurogenic bladder dysfunctions in neurological disorders

患有多发性硬化症、帕金森氏病、阿尔茨海默氏症等神经系统疾病的患者 肌萎缩侧索硬化症发展为一系列下尿路症状(LUTS) 包括尿急、尿频、大小便失禁、夜尿。观察到神经源性膀胱功能障碍 神经系统疾病的患者通常是由于周围和/或中枢神经受损所致。 系统。对下尿路功能障碍的病理生理学和发病机制缺乏了解 神经系统疾病阻碍了对这些疾病的治疗策略和治疗选择的发展 病人。为了响应RFA-DK-12-003，我们建议成立费城跨学科 神经原性膀胱功能障碍研究中心。中心的主要工作重点将放在 了解神经原性膀胱功能障碍的系统和细胞机制 中枢神经系统的变性，以阐明泌尿系统和神经系统之间的功能相互作用。 费城中心将：a)提供智力基础设施，以应对将成为 确定神经系统疾病下尿路感染潜在病因的综合方案；b) 建立一支融合良好的临床和基础科学研究人员的跨学科研究团队 大费城地区，将重点研究LUTS使用动物模型 神经源性膀胱功能障碍；c)将LUTS的表型从动物模型扩展到患者 被诊断为神经性疾病并抱怨LUTS，以及d)生成初步数据 有必要在完成本研究后提交计划项目(POI)。研究小组将包括 在神经病学、神经生理学、药理学方面拥有不同专业知识的资深研究人员， 微生物学、神经退行性变和临床神经学。费城IR-BU中心包括：1) 关键研究人员及其合作者的实验室结合了神经学方面的专业知识， 神经病学、神经生理学、细胞生物学、微生物学、神经科学、药理学和 病理学；2)行政核心，提供行政和财政监督，质量控制 研究、协调中心主要研究人员之间的互动并组织月刊 会议；3)动物组织核心，提供不同程度神经变性的小鼠组织 和基础研究项目的脱髓鞘；4)吸引年轻人的教育充实计划 向泌尿学领域的研究人员提供培训，并支持他们在关键调查人员的实验室进行研究。

Patients with neurological disorders such as multiple sclerosis, Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis develop a wide range of lower urinary tract symptoms (LUTS) including urinary urgency, frequency, incontinence, nocturia. Neurogenic bladder dysfunctions observed in patients with neurological disorders usually result from damage to the peripheral and/or central nervous systems. The lack of understanding of pathophysiology and mechanisms underlying LUT dysfunctions in neurological disorders hampers the development of therapeutic strategies and treatment options for these patients. In response to the RFA-DK-12-003, we propose to form the Philadelphia Interdisciplinary Research Center on Neurogenic Bladder Dysfunctions. The primary focus of the Center will be on understanding the systemic and cellular mechanisms of neurogenic bladder dysfunctions resulting from degeneration in the CNS in order to clarify functional interplay between the urologic and nen/ous systems. The Philadelphia Center will: a) provide the intellectual infrastructure to tackle on projects that will become comprehensive programs determining the underlying etiology of LUTS in neurological disorders; b) establish a well-integrated interdisciplinary research team of clinical and basic science researchers in the Greater Philadelphia area which will focus the research efforts on LUTS using animal models of neurogenic bladder dysfunctions; c) extend the phenotyping of LUTS from animal models to patients diagnosed with neurological disorders and complaining of LUTS, and d) generate preliminary data necessary to submit a program project (POI) after completion of this study. The research team will include established investigators with diverse expertise in neurourology, neurophysiology, pharmacology, microbiology, neurodegeneration, and clinical neurology. The Philadelphia IR-BU Center W\\\ consist of: 1) the laboratories of key investigators and their collaborators that combine expertise in neurology, neurourology, neurophysiology, cellular biology, microbiology, neuroscience, pharmacology, and pathology; 2) an Administrative Core to provide administrative and fiscal oversight, quality control for the research, coordination of interactions among key investigators in the Center and organization of monthly meetings; 3) an Animal tissue core to provide tissues from mice with different levels of neurodegeneration and demyelination for basic research projects; 4) an Educational Enrichment Program to attract young investigators to the field of urology and support their research in the laboratories of key investigators.