One Health Innovation Fellowships for Zoonotic Disease Research In Mongolia

项目概要/摘要 响应全球卫生创新框架计划，该提案建立在一个 建立了美国-蒙古多学科伙伴关系，以解决蒙古的人畜共患病负担。在 近几十年来，蒙古经历了重大的经济和环境变化， 许多人畜共患病的大规模流行。本次提交的长期目标是制定一个全球性的 健康培训计划，鼓励创新，多学科团队解决问题的解决方案，以发展 产品，改变疾病过程，并指导政策，控制人畜共患疾病，在低或中等， 收入国家。在这方面，我们将采用一个健康跨学科的培训和培养 为一名美国人和两名蒙古人在公共、兽医和环境卫生部门开展合作 每年博士后培训人员（2年培训期）。这些专业人员将包括一个3人的'一 代表三个卫生部门的卫生小组。在5年期间，4个此类小组（12个 博士后研究员）将从事人畜共患病问题解决。在两年期的第一阶段， 团队将在佛罗里达大学（UF）进行为期2个月的培训。将获得9个学分 小时的一个健康教学培训（一个健康证书）以及道德行为的培训， 人类和动物研究。在佛罗里达期间，博士后团队将每周与一个六人小组会面， 内部咨询委员会成员（IAC，4名美国成员和3名蒙古成员），将提出人畜共患病 疾病的问题，并指导他们在从事不同的专家组在用友在开发一个试点研究 项目和预算。在佛罗里达，博士后团队将推销他们的人畜共患病问题， 他们的项目的想法，在UF各专业团体（如动物科学，食品安全， 环境工程师，生态学家，地理学家，以及新兴疾病，公共卫生， 兽医卫生专业人员），目标是确定问题的创新解决方案， 确定UF和后来的蒙古研究导师。在第一阶段培训的最后一周， 博士后团队将向IAC提交他们的项目，以获得最终批准和研究基金。的 博士后团队随后将前往蒙古，并在最合适的地方设立研究总部 蒙古政府合作机构，并推进试点研究的执行。而 博士后团队将至少每周与导师接触，每月与IAC接触， 这个计划将强调独立的团队解决问题的博士后研究员。 蒙古将大大受益于全球一体化健康研究框架的实施， 健康创新。自1992年转向市场经济以来，蒙古经历了迅速的变化， 采矿作业和绵羊、山羊和牛的动物生产增加。很大一部分 通常游牧的牧民开始向城市地区迁移， 与新的环境地形无关的人类和动物种群。由于复杂的原因，双方 人类和动物遭受越来越多的人畜共患疾病，包括布鲁氏菌病，炭疽， 人畜共患流感、狂犬病和立克次体病。人畜共患病既有经济意义，也有健康意义 威胁，因为该国经济的很大一部分继续依赖动物生产。但由于 由于资源有限，蒙古卫生专业人员的研究和诊断能力有限。有 对公共、兽医和环境卫生基础设施发展的巨大需求 改善诊断实验室设施，加强监测网络， 针对复杂的人畜共患病预防和控制策略的健康教育。此程序将 加强机构能力，在两个区域开展创新的人畜共患病培训和研究， 佛罗里达大学和蒙古的多个合作卫生机构。它也将作为一个 在其他有人畜共患疾病负担的低收入中等收入国家开展类似干预的示范项目。 该项目的具体目标是：1）确定与人畜共患病相关的风险和条件 疾病发病率在蒙古; 2）通过采用现代技术，在一个大的多学科 美国大学，并遵循跨学科团队的方法，制定创新的一个健康战略 解决蒙古的人畜共患疾病问题; 3）采用培训培训员的办法， 向区域公共、动物和环境卫生专业人员提供预防和控制技术 4）将科学发现转化为预防措施或产品， 减少全世界牧民的人畜共患病负担。

PROJECT SUMMARY/ABSTRACT Responding to the Framework Programs for Global Health Innovation, this proposal builds upon an established US-Mongolia multidisciplinary partnership to address zoonotic disease burdens in Mongolia. In recent decades, Mongolia has experienced major economic and environmental changes, and suffered many large epidemics of zoonotic diseases. The long term goal of this submission is to develop a global health training program that elicits innovative, multidisciplinary team problem-solving solutions to develop products, alter disease processes, and guide policies in controlling zoonotic diseases in low- or middle- income countries. In this effort, we will employ One Health cross-disciplinary training and foster collaborations in public, veterinary, and environmental health sectors for one American and two Mongolian postdoctoral trainees per year (2-yr training period). These professionals will comprise a 3-person 'One Health' team that represents each of the three health sectors. Over the 5-yr period 4 such teams (12 postdoctoral fellows) will be engaged in zoonotic disease problem solving. In Phase I of the 2-yr period, teams will convene at the University of Florida (UF) for 2 months of training. They will receive 9 credit hours of One Health didactic training (Certificate in One Health) as well as training in ethical conduct of human and animal research. While in Florida, the postdoctoral teams will meet each week with a six- member Internal Advisory Committee (IAC, 4 US and 3 Mongolian members) who will pose zoonotic disease problems and guide them in engaging diverse expert groups at UF in developing a pilot research project and budget. While in Florida, the postdoctoral team will pitch their zoonotic disease problems and their ideas for projects to various professional groups at UF (e.g. animal science, food safety, environmental engineers, ecologists, geographers, as well as emerging disease, public health, and veterinary health professionals) with a goal of identifying innovative solutions to the problem and identifying UF and later Mongolian research mentors. During the last week of Phase I training, the postdoctoral team will present their project to the IAC for final approval and research fund release. The postdoctoral team will then travel to Mongolia and set up a research headquarters in the most appropriate Mongolian government collaborating institution, and move forward with pilot study execution. While the postdoctoral team will have at least weekly contact with their mentors and monthly contact with the IAC, this program will emphasize independent team problem solving by the postdoctoral fellows. Mongolia will greatly benefit from the implementation of a One Health research framework for global health innovation. Since moving to a market economy in 1992, Mongolia has undergone rapid change with increases in mining operations and animal production of sheep, goats, and cattle. Large segments of the normally nomadic pastoral populations have begun migrating to urban areas and introducing previously unconnected human and animal populations to new environmental terrains. For complex reasons, both humans and animals have suffered from increased zoonotic diseases, including brucellosis, anthrax, zoonotic influenza, rabies, and rickettsial diseases. Zoonotic diseases are both economic and health threats, as a large portion of the country's economy continues to rely upon animal production. Yet due to limited resources, Mongolia's health professionals have limited research and diagnostic capacity. There is a tremendous need for infrastructure development in the public, veterinary, and environmental health sectors, improved diagnostic laboratory facilities, stronger surveillance networks, and advanced One Health education to address complex zoonotic disease prevention and control strategies. This program will strengthen institutional capacity for innovative zoonotic disease training and research at both the University of Florida and at the multiple collaborating health institutions in Mongolia. It will also serve as a model program for similar interventions in other LMIC countries with zoonotic disease burdens. The specific aims of this project are to 1) identify the risks and conditions associated with zoonotic disease morbidity in Mongolia; 2) by employing modern technologies available at a large multidisciplinary US university and following a cross-disciplinary team approach, develop innovative One Health strategies to solve zoonotic disease problems in Mongolia; 3) following a train-the-trainer approach, transfer novel prevention and control techniques to regional public, animal, and environmental health professionals throughout Mongolia; and 4) translate scientific findings into prevention practices or products that will help to reduce the burden of zoonotic diseases among pastoral people worldwide.