One Health Innovation Fellowships for Zoonotic Disease Research In Mongolia

项目概要/摘要 为了响应全球健康创新框架计划，该提案建立在 建立了美国-蒙古多学科伙伴关系，以解决蒙古的人畜共患疾病负担。在 近几十年来，蒙古国经历了重大的经济和环境变化， 许多人畜共患疾病的大规模流行。本次提交的长期目标是开发一个全球性的 健康培训计划，激发创新的多学科团队解决问题的解决方案 产品，改变疾病过程，并指导控制中低水平人畜共患疾病的政策 收入国家。在这一努力中，我们将采用 One Health 跨学科培训并培养 一名美国人和两名蒙古人在公共、兽医和环境卫生部门的合作 每年招收博士后（培训期为2年）。这些专业人员将组成一个由 3 人组成的“One 代表三个卫生部门的健康团队。在 5 年期间，有 4 个这样的团队（12 博士后研究员）将从事人畜共患疾病问题的解决。在两年期的第一阶段， 各队将齐聚佛罗里达大学 (UF) 进行为期 2 个月的训练。他们将获得 9 学分 小时的 One Health 教学培训（One Health 证书）以及道德行为培训 人类和动物研究。在佛罗里达州期间，博士后团队每周都会与六名博士后人员会面。 内部咨询委员会成员（IAC、4 名美国成员和 3 名蒙古成员）将提出人畜共患病 疾病问题，并指导他们与佛罗里达大学的不同专家组合作开展试点研究 项目和预算。在佛罗里达州期间，博士后团队将提出他们的人畜共患疾病问题，并 他们向佛罗里达大学各个专业团体提出的项目想法（例如动物科学、食品安全、 环境工程师、生态学家、地理学家以及新出现的疾病、公共卫生和 兽医保健专业人员），目标是找到问题的创新解决方案， 确定佛罗里达大学和后来的蒙古研究导师。在第一阶段训练的最后一周， 博士后团队将向IAC提交他们的项目以获得最终批准和研究基金发放。的 随后博士后团队将前往蒙古国并在最合适的地方设立研究总部 蒙古政府合作机构，并推进试点研究的执行。虽然 博士后团队将至少每周与导师联系，每月与 IAC 联系， 该项目将强调博士后研究员独立团队解决问题的能力。 蒙古将从全球“同一个健康”研究框架的实施中受益匪浅 健康创新。自1992年实行市场经济以来，蒙古国经历了迅速的变化， 采矿作业以及绵羊、山羊和牛的动物生产增加。的大部分 通常游牧的牧民已经开始向城市地区迁移，并引入了以前的 人类和动物种群与新的环境地形没有联系。由于复杂的原因，双方 人类和动物遭受的人畜共患疾病增加，包括布鲁氏菌病、炭疽病、 人畜共患流感、狂犬病和立克次体病。人畜共患疾病既经济又健康 威胁，因为该国经济的很大一部分仍然依赖畜牧生产。然而由于 由于资源有限，蒙古卫生专业人员的研究和诊断能力有限。有 公共、兽医和环境健康方面对基础设施发展的巨大需求 部门、改进的诊断实验室设施、更强大的监测网络和先进的一 健康教育解决复杂的人畜共患疾病预防和控制策略。该计划将 加强两个国家和地区创新人畜共患疾病培训和研究的机构能力 佛罗里达大学和蒙古的多个合作卫生机构。它还将作为 在其他具有人畜共患疾病负担的中低收入国家实施类似干预措施的示范计划。 该项目的具体目标是 1) 确定与人畜共患病相关的风险和条件 蒙古的疾病发病率； 2）利用大型多学科领域可用的现代技术 美国大学采用跨学科团队方法，制定创新的 One Health 战略 解决蒙古的人畜共患疾病问题； 3）遵循培训师培训方法，转移新颖性 向区域公共、动物和环境卫生专业人员提供预防和控制技术 整个蒙古； 4）将科学发现转化为有助于预防的实践或产品 减轻全世界牧民的人畜共患病负担。

PROJECT SUMMARY/ABSTRACT Responding to the Framework Programs for Global Health Innovation, this proposal builds upon an established US-Mongolia multidisciplinary partnership to address zoonotic disease burdens in Mongolia. In recent decades, Mongolia has experienced major economic and environmental changes, and suffered many large epidemics of zoonotic diseases. The long term goal of this submission is to develop a global health training program that elicits innovative, multidisciplinary team problem-solving solutions to develop products, alter disease processes, and guide policies in controlling zoonotic diseases in low- or middle- income countries. In this effort, we will employ One Health cross-disciplinary training and foster collaborations in public, veterinary, and environmental health sectors for one American and two Mongolian postdoctoral trainees per year (2-yr training period). These professionals will comprise a 3-person 'One Health' team that represents each of the three health sectors. Over the 5-yr period 4 such teams (12 postdoctoral fellows) will be engaged in zoonotic disease problem solving. In Phase I of the 2-yr period, teams will convene at the University of Florida (UF) for 2 months of training. They will receive 9 credit hours of One Health didactic training (Certificate in One Health) as well as training in ethical conduct of human and animal research. While in Florida, the postdoctoral teams will meet each week with a six- member Internal Advisory Committee (IAC, 4 US and 3 Mongolian members) who will pose zoonotic disease problems and guide them in engaging diverse expert groups at UF in developing a pilot research project and budget. While in Florida, the postdoctoral team will pitch their zoonotic disease problems and their ideas for projects to various professional groups at UF (e.g. animal science, food safety, environmental engineers, ecologists, geographers, as well as emerging disease, public health, and veterinary health professionals) with a goal of identifying innovative solutions to the problem and identifying UF and later Mongolian research mentors. During the last week of Phase I training, the postdoctoral team will present their project to the IAC for final approval and research fund release. The postdoctoral team will then travel to Mongolia and set up a research headquarters in the most appropriate Mongolian government collaborating institution, and move forward with pilot study execution. While the postdoctoral team will have at least weekly contact with their mentors and monthly contact with the IAC, this program will emphasize independent team problem solving by the postdoctoral fellows. Mongolia will greatly benefit from the implementation of a One Health research framework for global health innovation. Since moving to a market economy in 1992, Mongolia has undergone rapid change with increases in mining operations and animal production of sheep, goats, and cattle. Large segments of the normally nomadic pastoral populations have begun migrating to urban areas and introducing previously unconnected human and animal populations to new environmental terrains. For complex reasons, both humans and animals have suffered from increased zoonotic diseases, including brucellosis, anthrax, zoonotic influenza, rabies, and rickettsial diseases. Zoonotic diseases are both economic and health threats, as a large portion of the country's economy continues to rely upon animal production. Yet due to limited resources, Mongolia's health professionals have limited research and diagnostic capacity. There is a tremendous need for infrastructure development in the public, veterinary, and environmental health sectors, improved diagnostic laboratory facilities, stronger surveillance networks, and advanced One Health education to address complex zoonotic disease prevention and control strategies. This program will strengthen institutional capacity for innovative zoonotic disease training and research at both the University of Florida and at the multiple collaborating health institutions in Mongolia. It will also serve as a model program for similar interventions in other LMIC countries with zoonotic disease burdens. The specific aims of this project are to 1) identify the risks and conditions associated with zoonotic disease morbidity in Mongolia; 2) by employing modern technologies available at a large multidisciplinary US university and following a cross-disciplinary team approach, develop innovative One Health strategies to solve zoonotic disease problems in Mongolia; 3) following a train-the-trainer approach, transfer novel prevention and control techniques to regional public, animal, and environmental health professionals throughout Mongolia; and 4) translate scientific findings into prevention practices or products that will help to reduce the burden of zoonotic diseases among pastoral people worldwide.