One Health Innovation Fellowships for Zoonotic Disease Research In Mongolia

项目摘要/摘要 作为对全球卫生创新框架计划的回应，这项提议建立在 建立了美蒙多学科伙伴关系，以解决蒙古的人畜共患疾病负担问题。在……里面 近几十年来，蒙古经历了重大的经济和环境变化，并遭受了 许多人畜共患疾病的大规模流行。这份意见书的长期目标是制定一项全球 健康培训计划，激发创新的、多学科的团队解决问题的解决方案 产品，改变疾病流程，指导控制中低度人畜共患病的政策。 收入国家。在这项工作中，我们将采用一个健康跨学科的培训和培养 为一名美国人和两名蒙古人在公共、兽医和环境卫生部门进行合作 每年博士后实习生人数(2年培训期)。这些专业人员将组成一个三人小组 代表三个卫生部门的卫生‘团队。在5年内，有4个这样的团队(12 博士后)将致力于解决人畜共患疾病问题。在两年期的第一阶段， 参赛队将在佛罗里达大学(UF)进行为期两个月的训练。他们将获得9个学分 一个健康教育培训小时(一个健康证书)以及道德行为培训 人类和动物研究。在佛罗里达期间，博士后团队每周将与六位博士后会面- 将构成人畜共患病的内部咨询委员会成员(IAC，4名美国成员和3名蒙古成员) 疾病问题，并指导他们参与密歇根大学的不同专家小组开展试点研究 项目和预算。在佛罗里达期间，博士后团队将介绍他们的人畜共患疾病问题和 他们向密歇根大学不同的专业团体(如动物科学、食品安全、 环境工程师、生态学家、地理学家，以及新出现的疾病、公共卫生和 兽医保健专业人员)，目的是找出问题的创新解决方案，并 确定UF和后来的蒙古研究导师。在第一阶段培训的最后一周， 博士后团队将向IAC提交他们的项目，以供最终批准和研究基金发放。这个 博士后团队随后将前往蒙古，并在最合适的地方设立研究总部 蒙古国政府合作机构，并推进试点研究执行。而当 博士后团队将至少每周与他们的导师接触，每月与IAC接触， 该项目将强调由博士后研究员独立团队解决问题。 蒙古将从全球统一卫生研究框架的实施中受益匪浅 健康创新。自1992年进入市场经济以来，蒙古经历了迅速的变化 增加采矿作业和绵羊、山羊和牛的畜牧业生产。很大一部分 正常的游牧人口已经开始迁移到城市地区，并引入了以前的 没有将人类和动物种群与新的环境地形联系起来。出于复杂的原因，两者 人类和动物遭受了越来越多的人畜共患疾病，包括布鲁氏菌病、炭疽病、 人畜共患流感、狂犬病和立克次体疾病。人畜共患疾病既有经济价值，又有健康价值 由于该国经济的很大一部分仍依赖于畜牧业生产，因此面临着巨大的威胁。然而，由于 由于资源有限，蒙古卫生专业人员的研究和诊断能力有限。的确有 在公共、兽医和环境卫生方面对基础设施发展的巨大需求 部门、改进的诊断实验室设施、更强大的监测网络和先进的监测网络 针对复杂的人畜共患疾病的预防和控制策略进行健康教育。这一计划将 加强创新人畜共患疾病培训和研究的机构能力 在佛罗里达大学和蒙古的多个合作医疗机构。它还将作为一个 在其他有人畜共患疾病负担的LMIC国家开展类似干预的示范方案。 该项目的具体目标是：1)确定与人畜共患病相关的风险和状况 蒙古的疾病发病率；2)利用大型多学科可用的现代技术 美国大学和遵循跨学科团队的方法，开发创新的One Health策略 解决蒙古的人畜共患疾病问题；3)遵循培训员培训的方法，转移新的 向区域公众、动物和环境卫生专业人员提供预防和控制技术 在蒙古全境；以及4)将科学发现转化为有助于 减轻世界各地牧民中人畜共患疾病的负担。

PROJECT SUMMARY/ABSTRACT Responding to the Framework Programs for Global Health Innovation, this proposal builds upon an established US-Mongolia multidisciplinary partnership to address zoonotic disease burdens in Mongolia. In recent decades, Mongolia has experienced major economic and environmental changes, and suffered many large epidemics of zoonotic diseases. The long term goal of this submission is to develop a global health training program that elicits innovative, multidisciplinary team problem-solving solutions to develop products, alter disease processes, and guide policies in controlling zoonotic diseases in low- or middle- income countries. In this effort, we will employ One Health cross-disciplinary training and foster collaborations in public, veterinary, and environmental health sectors for one American and two Mongolian postdoctoral trainees per year (2-yr training period). These professionals will comprise a 3-person 'One Health' team that represents each of the three health sectors. Over the 5-yr period 4 such teams (12 postdoctoral fellows) will be engaged in zoonotic disease problem solving. In Phase I of the 2-yr period, teams will convene at the University of Florida (UF) for 2 months of training. They will receive 9 credit hours of One Health didactic training (Certificate in One Health) as well as training in ethical conduct of human and animal research. While in Florida, the postdoctoral teams will meet each week with a six- member Internal Advisory Committee (IAC, 4 US and 3 Mongolian members) who will pose zoonotic disease problems and guide them in engaging diverse expert groups at UF in developing a pilot research project and budget. While in Florida, the postdoctoral team will pitch their zoonotic disease problems and their ideas for projects to various professional groups at UF (e.g. animal science, food safety, environmental engineers, ecologists, geographers, as well as emerging disease, public health, and veterinary health professionals) with a goal of identifying innovative solutions to the problem and identifying UF and later Mongolian research mentors. During the last week of Phase I training, the postdoctoral team will present their project to the IAC for final approval and research fund release. The postdoctoral team will then travel to Mongolia and set up a research headquarters in the most appropriate Mongolian government collaborating institution, and move forward with pilot study execution. While the postdoctoral team will have at least weekly contact with their mentors and monthly contact with the IAC, this program will emphasize independent team problem solving by the postdoctoral fellows. Mongolia will greatly benefit from the implementation of a One Health research framework for global health innovation. Since moving to a market economy in 1992, Mongolia has undergone rapid change with increases in mining operations and animal production of sheep, goats, and cattle. Large segments of the normally nomadic pastoral populations have begun migrating to urban areas and introducing previously unconnected human and animal populations to new environmental terrains. For complex reasons, both humans and animals have suffered from increased zoonotic diseases, including brucellosis, anthrax, zoonotic influenza, rabies, and rickettsial diseases. Zoonotic diseases are both economic and health threats, as a large portion of the country's economy continues to rely upon animal production. Yet due to limited resources, Mongolia's health professionals have limited research and diagnostic capacity. There is a tremendous need for infrastructure development in the public, veterinary, and environmental health sectors, improved diagnostic laboratory facilities, stronger surveillance networks, and advanced One Health education to address complex zoonotic disease prevention and control strategies. This program will strengthen institutional capacity for innovative zoonotic disease training and research at both the University of Florida and at the multiple collaborating health institutions in Mongolia. It will also serve as a model program for similar interventions in other LMIC countries with zoonotic disease burdens. The specific aims of this project are to 1) identify the risks and conditions associated with zoonotic disease morbidity in Mongolia; 2) by employing modern technologies available at a large multidisciplinary US university and following a cross-disciplinary team approach, develop innovative One Health strategies to solve zoonotic disease problems in Mongolia; 3) following a train-the-trainer approach, transfer novel prevention and control techniques to regional public, animal, and environmental health professionals throughout Mongolia; and 4) translate scientific findings into prevention practices or products that will help to reduce the burden of zoonotic diseases among pastoral people worldwide.