Ectopic fat and atherosclerosis in South Asians

南亚人的异位脂肪和动脉粥样硬化

• 批准号: 9262958
• 负责人: ALKA M. KANAYA
• 金额: $ 11.71万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-01 至 2018-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9262958
• 关键词: Abdomen; Adipose tissue; Age; Age Distribution; Asian Indian; Atherosclerosis; Award; Bangladeshi; Biometry; Body Composition; Body Size; Body fat; Body mass index; Calcium; California; Cardiac; Cardiovascular Diseases; Cardiovascular system; Categories; Clinical Investigator; Clinical Sciences; Cohort Studies; Complement; Coronary artery; Data; Development Plans; Diabetes Mellitus; Diagnostic radiologic examination; Disease; Disease Outcome; Epidemiology; Ethnic group; Etiology; Event; Fatty acid glycerol esters; Funding; Future; Goals; Grant; Heart Diseases; Hepatic; Heterogeneity; High Prevalence; Hormones; Individual; Inflammatory; Institutes; Interleukin-6; Internal Medicine; Intervention; Leptin; Link; Location; Longitudinal Studies; Longitudinal cohort; Measurement; Measures; Medicine; Mentors; Metabolic; Metabolic Diseases; Methods; Minority Groups; Modeling; Multi-Ethnic Study of Atherosclerosis; National Heart, Lung, and Blood Institute; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Outcome; Overweight; Pericardial body location; Pilot Projects; Population; Prevalence; Prevention; Prospective cohort study; Research; Research Infrastructure; Research Personnel; Resources; Risk; Risk Factors; San Francisco; South Asian; TNF gene; Techniques; Testing; Time; Training; Translational Research; United States; United States National Institutes of Health; Universities; Ursidae Family; Visceral; adipokines; adiponectin; cardiovascular risk factor; career; career development; cost effective; cytokine; design; disorder risk; ethnic minority population; glucose tolerance; high risk; intimal medial thickening; mid-career faculty; multidisciplinary; novel; patient oriented; patient oriented research; programs; research and development; resistin; sex; sobriety; socioeconomics; subcutaneous; waist circumference

DESCRIPTION (provided by applicant): Dr. Alka Kanaya is an Associate Professor in the Departments of Medicine, Epidemiology and Biostatistics at the University of California San Francisco. Trained in Internal Medicine and Epidemiology, over the past decade she has mentored several individuals at different levels in their training and developed a thriving program of multidisciplinary collaborative research focused on diabetes and cardiovascular disease epidemiology and prevention. Dr. Kanaya is at an ideal stage of her career for a K24 grant. Support from this award would allow her to leverage her research program to develop the careers of new patient-oriented researchers. She is currently funded by the NHLBI to conduct a prospective cohort study of South Asians called the MASALA study which is modeled on the existing Multi-Ethnic Study of Atherosclerosis (MESA) to understand the antecedents of diabetes and cardiovascular disease in this high risk ethnic group. With the support of the K24, Dr. Kanaya will extend the research program by adding measurements of ectopic fat and adipokines to the MASALA study cohort and make comparisons to four other U.S. ethnic groups in MESA. The Overall Aims of this K24 proposal are: (1) To measure ectopic fat depots and adipokines among 900 South Asians in the MASALA study and to describe and compare ectopic fat depots and adipokines between the South Asians and the four MESA ethnic groups after adjusting for age and overall body size. (2) To test the hypothesis that higher ectopic fat will be associated with worsened glucose tolerance; that adipokines will explain the association between the ectopic fat depots and glucose tolerance status; and that the increased prevalence of diabetes among the South Asians compared to the MESA ethnic groups will be explained by the ectopic fat depot and adipokines. (3) To test the hypothesis that higher amounts of ectopic fat will be associated with greater subclinical atherosclerosis; that adipokines will explain the association between the ectopic fat depots and subclinical atherosclerosis; and that the difference in subclinical atherosclerosis prevalence among the South Asians compared to the MESA ethnic groups can be explained by the ectopic fat depot and adipokines. (4) To determine whether baseline levels of ectopic fat are independently associated with incident cardiovascular events among South Asians after adjusting for traditional cardiovascular risk factors; and whether differences in CVD outcomes between South Asians and the MESA ethnic groups can be explained by the ectopic fat depot and adipokine levels. The K24 would insure sufficient time to pursue this natural progression of Dr. Kanaya's research while protecting time to devote to mentoring future clinical investigators in patient-oriented research. The plans for development, research, and mentoring were designed to complement each other and to create a synergistic effect of mentoring and research in patient-oriented research. The proposed mentoring, research, and career development activities actively leverage existing infrastructure, resources, and training initiatives provided by NIH, including Dr. Kanaya's active research program and the Clinical and Translational Science Institute (CTSI) at UCSF.

描述（由申请人提供）：Alka Kanaya博士是加利福尼亚大学旧金山大学医学，流行病学和生物统计学系的副教授。在过去的十年中，她接受了内科和流行病学的培训 多学科合作研究的重点是糖尿病和心血管疾病流行病学和预防。 Kanaya博士处于K24 Grant职业生涯的理想阶段。该奖项的支持将使她能够利用自己的研究计划发展新的面向患者的研究人员的职业。她目前由NHLBI资助，对南亚人进行了一项名为Masala研究的前瞻性队列研究，该研究以现有的动脉粥样硬化多民族研究（MESA）为模型，以了解这个高风险族群中糖尿病和心血管疾病的前因。在K24的支持下，Kanaya博士将通过将异位脂肪和脂肪因子的测量值添加到Masala研究队列中，并与MESA的其他四个美国族裔进行比较。该K24提案的总体目的是：（1）在Masala研究中，在900个南亚人中测量异位脂肪仓库和脂肪因子，并在调整年龄和整体体型后描述和比较南亚人和四个MESA种族之间的异位脂肪仓库和脂肪因子。 （2）检验以下假设：较高的异位脂肪将与葡萄糖耐受性恶化有关；脂肪因子将解释异位脂肪库与葡萄糖耐量状态之间的关联。与梅萨族相比，南亚人中糖尿病患病率的增加将由异位脂肪仓库和脂肪因子解释。 （3）检验以下假设：较高量的异位脂肪将与较大的亚临床动脉粥样硬化有关；脂肪因子将解释异位脂肪库与亚临床动脉粥样硬化之间的关联。与梅萨族相比，南亚人的亚临床动脉粥样硬化患病率的差异可以通过异位脂肪仓库和脂肪因子来解释。 （4）确定异位脂肪的基线水平是否在调整了传统的心血管危险因素后，南亚人之间的心血管事件是否独立相关；以及南亚人与梅萨族之间CVD结局的差异是否可以通过异位脂肪仓库和脂肪因子水平来解释。 K24将确保足够的时间追求卡纳亚博士研究的自然发展，同时保护时间用于指导未来的临床研究人员，以患者为导向的研究。开发，研究和指导的计划旨在相互补充，并在以患者为导向的研究中产生指导和研究的协同作用。拟议的指导，研究和职业发展活动积极利用NIH提供的现有基础设施，资源和培训计划，包括Kanaya博士的主动研究计划以及UCSF的临床和转化科学研究所（CTSI）。