Training Program in Molecular Medicine

分子医学培训计划

• 批准号: 8475252
• 负责人: Lynn COOLEY
• 金额: $ 8.93万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-01 至 2018-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8475252
• 关键词: Molecular Medicine; Training Programs

DESCRIPTION (provided by applicant): In 2006 Yale started the innovative Medical Research Scholars Program (MRSP) with the mission of providing broad and deep Ph.D. training in the core basic science concepts of molecular biology, cell biology, biochemistry, genetics, physiology, pharmacology, and pathology, integrated with intensive exposure to medically oriented coursework and mentored clinical experiences designed specifically for Ph.D. students. The ultimate goal of this training is to prepare our students to be future interdisciplinary leader in the biomedical sciences, with a unique ability to pursue clinically relevant fundamental basic science inquiry aimed at elucidating the molecular mechanisms of disease. The MRSP has been supported by a combination of institutional funds and funds provided by the Howard Hughes Medical Institute (HHMI). The combination of substantial unmet demand from highly qualified students for admission (warranting expansion of the size of MRSP), the termination of HHMI support after the 2013-2014 academic year, and the desire to continue this highly successful ongoing program constitute the rationale for our Molecular Medicine (MM) Training Grant application. MRSP students participate in a variety of program activities designed to engage Ph.D. students in medically relevant training and experiences throughout their graduate studies. The classes focus first on normal human physiology, organ-based cell biology, and biostatistics, followed by human pathobiology and an introduction to drug discovery, validation, and clinical trials. MRSP students also have the option to participate with first-year Yale MD students in weekly small-group physiology "case conference" tutorials, in which they explore in depth the physiological underpinnings of particular disease states. The cornerstone of the MRSP is a two-year mentored clinical experience that provides students with in-depth exposure to the science behind human diseases and first-hand longitudinal encounters with patients to contextualize the mechanistic basis of disease in a way that is not possible through traditional classroom learning. In addition, MRSP students participate in a special research-in-progress series held jointly with the Yale Center for Clinical Investigation (YCCI)-an NIH-funded center that forms the nucleus for translational and mechanistic disease-focused research at Yale-and as the program grows we plan to incorporate an Annual Retreat (also in conjunction with the YCCI). In addition to these formal activities, the MRSP also provides ongoing mentoring to all MRSP trainees regarding selection of a thesis research laboratory and assembly of the dissertation committee to support the goal of the NIGMS Molecular Medicine program to provide training in the basic biomedical sciences with a focus on elucidating the mechanisms of human disease. Accordingly, we request funds for this MM Training Grant to support a total of five MRSP Ph.D. students per class year, with five second-year and five third-year students being supported at any given time (all first-year students are fully supported by institutional funds), with the expectation that MRSP students will complete the Ph.D. within six years.

描述（由申请人提供）：2006年，耶鲁大学启动了创新的医学研究学者计划（MRSP），其使命是在分子生物学、细胞生物学、生物化学、遗传学、生理学、药理学和病理学的核心基础科学概念方面提供广泛而深入的博士培训，并结合密集的医学导向课程和专门为博士生设计的指导临床经验。该培训的最终目标是培养学生成为未来生物医学科学领域的跨学科领导者，具有独特的能力，从事临床相关的基础科学研究，旨在阐明疾病的分子机制。MRSP得到了机构资金和霍华德休斯医学研究所（HHMI）提供的资金的支持。高素质学生的大量未满足的入学需求（保证MRSP规模的扩大），2013-2014学年结束后HHMI支持的终止，以及继续这个非常成功的正在进行的项目的愿望，构成了我们分子医学（MM）培训资助申请的理由。MRSP学生参加各种项目活动，旨在吸引博士生在他们的研究生学习中进行医学相关的培训和经验。课程首先集中在正常的人体生理学、器官细胞生物学和生物统计学，然后是人类病理生物学和药物发现、验证和临床试验的介绍。MRSP的学生还可以选择与耶鲁大学医学博士一年级学生一起参加每周一次的小组生理学“病例会议”辅导，在会上他们将深入探讨特定疾病状态的生理学基础。MRSP的基础是为期两年的临床指导经验，为学生提供深入了解人类疾病背后的科学和与患者的第一手纵向接触，以一种传统课堂学习无法实现的方式将疾病的机制基础置于背景中。此外，MRSP学生参加与耶鲁临床研究中心（YCCI）联合举办的特别研究进展系列，YCCI是美国国立卫生研究院资助的中心，形成了耶鲁转化和机械疾病研究的核心，随着项目的发展，我们计划纳入年度务静会（也与YCCI一起）。除了这些正式的活动外，MRSP还为所有MRSP学员提供关于论文研究实验室的选择和论文委员会的集合的持续指导，以支持NIGMS分子医学计划的目标，即提供基础生物医学科学的培训，重点是阐明人类疾病的机制。因此，我们要求这个MM培训补助金每学年支持五名MRSP博士生，任何时候都支持五名二年级学生和五名三年级学生（所有一年级学生都由机构资金全额支持），期望MRSP学生在六年内完成博士学位。