Oxarane-Acrylate System to Double the Clinical Service Life of Restorative Resins

氧杂环丙烷-丙烯酸酯系统可将修复树脂的临床使用寿命延长一倍

• 批准号: 8610770
• 负责人: H. RALPH RAWLS
• 金额: $ 43.7万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2018-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8610770
• 关键词: Accounting; Acrylates; Address; Animals; Anti-Bacterial Agents; Award; Bacteria; Biochemical; Biocompatible Materials; Biomedical Engineering; Bisphenol A-Glycidyl Methacrylate; Calcium; Characteristics; Chemical Engineering; Clinical; Clinical Research; Clinical Services; Color; Composite Dental Resin; Delayed Hypersensitivity; Dental; Dental Enamel; Dental Pulp; Dental caries; Dentin; Dentistry; Doctor of Philosophy; Environment; Esters; Ethylene Oxide; Event; Exposure to; Fatigue; Filler; Fluorine; Goals; Hydrolysis; Hydrophobicity; Hydroquinones; Hypersensitivity; In Situ; In Vitro; Incidence; Ions; Life; Longevity; Mastication; Mechanics; Methacrylates; Microbial Biofilms; Minerals; Modeling; Nature; One-Step dentin bonding system; Oral; Oral cavity; Oral health; Oral mucous membrane structure; Oxygen; Performance; Plant Resins; Polymer Chemistry; Polymers; Predisposition; Property; Recurrence; Relaxation; Residual state; Resistance; Science; Scientist; Side; Silver; Solid; Stress; Structure; Surface; System; Testing; Urethane; Viscosity; Water; Work; analog; antimicrobial; bacterial resistance; base; biomaterial compatibility; bisphenol A; cost; crosslink; dental resin; design; dioxirane; esterase; hydroquinone; in vivo; innovation; inorganic phosphate; irritation; meetings; monomer; multidisciplinary; nanoparticle; novel; physical property; polymerization; public health relevance; response; restoration; restorative dentistry; restorative resins; triethylene glycol dimethacrylate; uptake

Oxarane-Acrylate System to Double the Clinical Service Life of Restorative Resins Abstract: In order to develop a novel restorative system with at least twice the lifetime of Bis-GMA/TEGDMA- based composites, their incomplete cure and susceptibility to hydrolysis and esterase degradation must be overcome. To address these problems, we will develop a novel superhydrophobic, degradation-resistant, dental restorative based on an Oxirane/Acrylate interpenetrating network System (OASys, pronounced Oasis). These novel monomers based on fluoridated urethanes with either dioxirane or diacrylate functionality can be highly converted to form a hydrophobic, degradation-resistant, tough and resilient interpenetrating polymer network (IPN) that is inherently highly crosslinked. By their nature, these characteristics impart low residual stresses, high resistance to hydrolytic and enzymatic degradation, and biocompatibility. We will also develop a novel one-step (primer-less), "smart," antimicrobial bonding resin with in situ-generated, colorless and color stable, silver nanoparticles (AgNPs). The bonding resin will contain a phosphate group plus both oxirane and acrylate functionalities. The oxirane and acrylate functionalities bond to the corresponding functionalities in the IPN resin matrix for potentially a much stronger bond than the conventional methacrylate system. The phosphate group will allow the bonding resin to wet etched mineral surfaces as well as bond directly to calcium in Ca-phosphate mineral structures. In the event of marginal gap formation, the "smart" in situ-generated AgNPs will release Ag+ ions and create an antibacterial environment, thereby further reducing the incidence of recurrent caries. Five specific aims are proposed: 1. To determine the effect of using oxiranes, increased hydrophobicity, and IPNs on resin mechanical properties, physical properties and in vitro biocompatibility. The more promising compositions will be combined with reinforcing filler and used for Aim 2. 2. To determine the effect of using a 4- Phospho-NPG GA oxirane (4POA)-based bonding system and in situ-generated silver nanoparticles (AgNP) on bonding resin mechanical properties, physical properties, and in vitro biocompatibility and antibacterial activity, as well as on bond strength to oxirane/acrylate interpenetrating network composites.. The two best- performing composites will be chosen for subsequent aims. 3. To determine the effect of using oxiranes, increased hydrophobicity, and IPNs on resin resistance to the oral biochemical environment. The two best- performing groups chosen in Aim 2 will be fatigue- and wear-tested after exposure to acidic, basic and esterase-containing environments for 90 days. 4. To determine the effect of using oxiranes, increased hydrophobicity, and IPNs on resin resistance to bacterial degradation. The two best-performing groups from Aim 2 will be tested in an artificial mouth bacterial biofilm model. 5. To determine the in vivo biocompatibility of the OASys. The best performing OASys will be tested in three in vivo biocompatibility models: delayed-type hypersensitivity, oral mucosa irritation, and pulp and dentin response tests. 1

环氧乙烷-丙烯酸酯体系使修复树脂的临床使用寿命延长一倍 翻译后摘要：为了开发一种新的修复系统，至少有两倍的寿命的双GMA/TEGDMA- 基复合材料，它们的不完全固化和对水解和酯酶降解的敏感性必须 克服为了解决这些问题，我们将开发一种新型的超疏水，抗降解， 基于环氧乙烷/丙烯酸酯互穿网络系统（OASys，发音为Oasis）的牙齿修复剂。 这些基于具有二环氧乙烷或二丙烯酸酯官能度的氟化双烯丙基醚的新型单体可 高度转化以形成疏水、抗降解、坚韧且有弹性的互穿聚合物 网络（IPN）是固有的高度交联。就其性质而言，这些特性赋予低残留 应力、高抗水解和酶降解性以及生物相容性。 我们还将开发一种新的一步（无底漆），“智能”，抗菌粘合树脂与原位生成， 无色且颜色稳定的银纳米颗粒（AgNP）。粘合树脂将含有磷酸基团加上 环氧乙烷和丙烯酸酯官能团。环氧乙烷和丙烯酸酯官能团键合到相应的 IPN树脂基质中的官能度可能比传统的甲基丙烯酸酯更强的键合 系统磷酸基团将允许粘结树脂润湿蚀刻的矿物表面以及粘结 直接转化为钙磷酸盐矿物结构中的钙。在边际缺口形成的情况下， 原位生成的AgNP将释放Ag+离子并产生抗菌环境，从而进一步减少 复发性龋齿的发生率。 提出了五个具体目标：1。为了确定使用环氧乙烷、增加的疏水性和 IPN对树脂机械性能、物理性能和体外生物相容性的影响。其中颇有发展前景的 组合物将与增强填料组合并用于目标2。2.为了确定使用4- 基于磷-NPG GA环氧乙烷（4POA）的键合系统和原位生成的银纳米颗粒（AgNP） 对粘接树脂的机械性能、物理性能、体外生物相容性和抗菌性 活性，以及对环氧乙烷/丙烯酸酯互穿网络复合材料的粘结强度。两个最好的- 将选择性能良好的复合材料用于后续目标。3.为了确定使用环氧乙烷的效果， 增加的疏水性和IPN对树脂对口腔生物化学环境的耐受性。两个最好的- 在目标2中选择的表演组将在暴露于酸性、碱性和碱性环境后进行疲劳和磨损测试， 含酯酶的环境90天。4.为了确定使用环氧乙烷的效果，增加了 疏水性和IPN对树脂耐细菌降解性的影响。来自的两个表现最好的团体 目的2将在人工口腔细菌生物膜模型中进行测试。5.为了确定生物相容性， OASys。性能最佳的OASys将在三种体内生物相容性模型中进行测试： 过敏、口腔粘膜刺激和牙髓和牙本质反应试验。 1