Novel Vehicle for Topical Delivery of Corticosteroids

皮质类固醇局部给药的新型载体

• 批准号: 6549778
• 负责人: H. RALPH RAWLS
• 金额: $ 10万
• 依托单位: BIOMEDICAL DEVELOPMENT CORPORATION
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-05 至 2004-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6549778
• 关键词: antiinflammatory agents; clinical research; corticosteroids; drug delivery systems; drug design /synthesis /production; drug screening /evaluation; drug vehicle; human subject; skin disorder; skin pharmacology; surface coating; topical drug application

DESCRIPTION (provided by applicant): Topical corticosteroids are useful treatment modalities for numerous dermatologic conditions. Most topical corticosteroids are applied in a cream or ointment vehicle, which require multiple applications, are subject to inadvertent removal, and can be cosmetically unacceptable. While efficacy has been shown to be increased with the use of hydrocolloid occlusive dressings, these dressings are often associated with local side effects and inherent cosmetic deficiencies. The goal of this project is to demonstrate the feasibility of using a novel coating technology as a topical delivery vehicle for corticosteroids that simultaneously serve as a semi-occlusive dressing. Coatings impregnated with corticosteroid will be formulated and tested to demonstrate efficacy in the vasoconstrictor assay in humans. PROPOSED COMMERCIAL APPLICATION: Topical corticosteroids are the most widely used preparations in dermatology. A novel vehicle that could improve efficacy and reduce treatments while being cost-effective would have significant commercial potential.

描述(由申请人提供)：局部皮质类固醇是治疗多种皮肤病的有效方法。大多数局部应用的皮质类固醇是在乳膏或软膏载体中使用的，这需要多次使用，容易被无意中移除，在美容上可能是不可接受的。虽然使用亲水胶体封闭敷料可以提高疗效，但这些敷料往往与局部副作用和固有的美容缺陷有关。 该项目的目标是证明使用一种新的涂层技术作为皮质类固醇局部给药载体的可行性，同时作为一种半闭塞敷料。浸渍皮质类固醇的涂层将被配制并进行测试，以证明在人体血管收缩试验中的有效性。 建议的商业应用：外用皮质类固醇是皮肤科使用最广泛的制剂。一种新的交通工具可以提高疗效和减少治疗，同时具有成本效益，将具有巨大的商业潜力。