NANOFILLER DEVELOPMENT

该项目提出开发基于以下的新型纳米填料树脂： 氧化钽和二氧化硅。我们的假设是， 可以保持当前微填充树脂的性能， 通过发展非- 聚集的纳米颗粒填料。 我们的总体战略和目标是合成Ta 2 O 5， SiO2纳米颗粒，具有不同的尺寸范围和表面化学性质， 为了优化树脂复合材料的四个性能：混合 流变粘度在高填料体积负荷，以获得 令人满意的加工/处理性能，耐磨韧性 以及耐磨性、可抛光性和透明度， 特征和用于诊断实用性的射线不透性。的理由 最优化可以通过合成填料 具有以下性质的颗粒：尺寸为100 nm或更小 以提供高抛光性并避免光散射（从而保持 半透明性）为110 nm或更大，以便有效地抑制 裂纹扩展（因此，提高耐磨性），独立和 非网络形成（从而限制粘度的增加并允许 足够高的体积负载以使结构增韧， 基本上抵消聚合收缩）、强相互作用和 与丙烯酸基质单体偶联以形成单相 材料（从而消除了界面断裂， 灾难性失效模式）和固有的不透射线性， 以调节X射线吸收（因此消除了 易于水解的重金属玻璃填料和能够实现射线不透性 与临床诊断要求相匹配 应用）。 具有上述性质的纳米填料构成了一个重大的进步 在恢复性材料，独立于其他项目内， 程序项目。与液晶单体和/或其组合一起， 牙本质诱导空洞治疗，纳米填料将形成一个 上级修复系统的组成部分， 牙科器械的组成部分和一个可行的汞合金 更换.

This project proposes to develop novel nanofiller resins based on tantalum oxide and silica. Our hypothesis is that the desirable properties of current microfilled resins can be retained while avoiding their major shortcomings through the development of non- aggregated nanoparticle fillers. Our overall strategy and objectives are to synthesize Ta2O5 and SiO2 nanoparticles, with varying size ranges and surface chemistries, in order to optimize four properties of resin composites: mixing rheology viscosity at high filler volume loadings to obtain satisfactory working/handling properties, toughness to resist wear and attrition, polishability and transparency to provide esthetic characteristics, and radiopacity for diagnostic utility. The rationale is that optimization can be accomplished by synthesizing filler particles that have the following properties: 100 nm or less in size to provide high polishability and avoid light scattering (thus retaining translucency)1 10 nm or more in size in order to efficiently inhibit crack-propagation (thus, enhancing wear resistance), independent and non-network forming (thus limiting viscosity buildup and allowing a high enough volume loading to toughen the structure and substantially offset polymerization shrinkage), strong interaction and coupling with acrylic matrix monomers so as to form a single phase material (thus eliminating interfacial fracture and the resulting catastrophic failure modes), and inherent radiopacity with the ability to adjust x-ray absorbance (therefore eliminating the need for hydrolysis-prone heavy-metal glass fillers and enabling radiopacity to be matched to the diagnostic requirements of the clinical application). Nanofillers with the above properties constitute a significant advance in restorative materials, independent of the other projects within the program project. Together with liquid crystal monomers and/or a dentin-inducing cavity treatment, nanofillers will form one component in a superior restorative system which can become an integral part of the dental armentarium and a viable amalgam replacement.