NANOFILLER DEVELOPMENT

本项目建议开发新型纳米填料树脂，其基础是 氧化钽和二氧化硅。我们的假设是，理想的 既能保持现有微填充树脂的性能，又能 通过发展非政府组织来避免它们的主要缺点 聚集的纳米颗粒填充物。 我们的总体战略和目标是合成Ta2O5和 二氧化硅纳米颗粒，具有不同的尺寸范围和表面化学成分， 为了优化树脂复合材料的四个性能：混合 在高填充量负荷下获得的流变性粘度 良好的工作/操控性能，坚韧耐磨 以及耐磨性、可磨性和透明度，以提供美观 特征，以及用于诊断用途的射线不透明度。其基本原理是 优化可以通过合成填料来完成 具有以下特性的颗粒：100纳米或更小 以提供高抛光性并避免光散射(从而保持 半透明)110 nm或更大，以便有效地抑制 裂纹扩展(从而提高耐磨性)，独立和 非网络形成(因此限制了粘度的积累并允许 足够高的体积载荷以使结构更坚韧 基本上抵消了聚合收缩)、强相互作用和 与丙烯酸类基质单体偶联，形成单一相 材料(从而消除了界面断裂和由此产生的 灾难性故障模式)，以及具有以下功能的固有放射不透明度 调整X射线吸光度(因此不再需要 易于水解的重金属玻璃填充物和实现放射不透明度 与临床诊断要求相匹配 申请)。 具有上述性质的纳米膜构成了一个重大的进步 在修复材料方面，独立于 计划项目。与液晶单体和/或 牙本质诱导空洞治疗，纳米滤膜将形成一个 高级恢复系统中的组件，可以成为 牙科医疗设备的组成部分和可行的银汞合金 替补。

This project proposes to develop novel nanofiller resins based on tantalum oxide and silica. Our hypothesis is that the desirable properties of current microfilled resins can be retained while avoiding their major shortcomings through the development of non- aggregated nanoparticle fillers. Our overall strategy and objectives are to synthesize Ta2O5 and SiO2 nanoparticles, with varying size ranges and surface chemistries, in order to optimize four properties of resin composites: mixing rheology viscosity at high filler volume loadings to obtain satisfactory working/handling properties, toughness to resist wear and attrition, polishability and transparency to provide esthetic characteristics, and radiopacity for diagnostic utility. The rationale is that optimization can be accomplished by synthesizing filler particles that have the following properties: 100 nm or less in size to provide high polishability and avoid light scattering (thus retaining translucency)1 10 nm or more in size in order to efficiently inhibit crack-propagation (thus, enhancing wear resistance), independent and non-network forming (thus limiting viscosity buildup and allowing a high enough volume loading to toughen the structure and substantially offset polymerization shrinkage), strong interaction and coupling with acrylic matrix monomers so as to form a single phase material (thus eliminating interfacial fracture and the resulting catastrophic failure modes), and inherent radiopacity with the ability to adjust x-ray absorbance (therefore eliminating the need for hydrolysis-prone heavy-metal glass fillers and enabling radiopacity to be matched to the diagnostic requirements of the clinical application). Nanofillers with the above properties constitute a significant advance in restorative materials, independent of the other projects within the program project. Together with liquid crystal monomers and/or a dentin-inducing cavity treatment, nanofillers will form one component in a superior restorative system which can become an integral part of the dental armentarium and a viable amalgam replacement.