Oxarane-Acrylate System to Double the Clinical Service Life of Restorative Resins

氧杂环丙烷-丙烯酸酯系统可将修复树脂的临床使用寿命延长一倍

• 批准号: 9130154
• 负责人: H. RALPH RAWLS
• 金额: $ 35.86万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2018-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9130154
• 关键词: Accounting; Acrylates; Address; Animals; Anti-Bacterial Agents; Award; Bacteria; Biochemical; Biocompatible Materials; Biomedical Engineering; Bisphenol A-Glycidyl Methacrylate; Calcium; Characteristics; Chemical Engineering; Clinical; Clinical Research; Clinical Services; Color; Composite Dental Resin; Delayed Hypersensitivity; Dental; Dental Enamel; Dental Pulp; Dental caries; Dentin; Dentistry; Doctor of Philosophy; Environment; Esters; Ethylene Oxide; Event; Exposure to; Fatigue; Filler; Fluorine; Goals; Health; Hydrolysis; Hydrophobicity; Hydroquinones; Hypersensitivity; In Situ; In Vitro; Incidence; Ions; Life; Longevity; Mastication; Mechanics; Methacrylates; Microbial Biofilms; Minerals; Modeling; Nature; One-Step dentin bonding system; Oral; Oral cavity; Oral health; Oral mucous membrane structure; Oxygen; Performance; Plant Resins; Polymer Chemistry; Polymers; Predisposition; Property; Recurrence; Relaxation; Residual state; Resistance; Scientist; Side; Silver; Solid; Stress; Structure; Surface; System; Testing; Urethane; Viscosity; Water; Work; analog; antimicrobial; bacterial resistance; base; biomaterial compatibility; bisphenol A; cost; crosslink; dental resin; design; dioxirane; esterase; in vivo; innovation; inorganic phosphate; irritation; materials science; meetings; monomer; multidisciplinary; nanoparticle; novel; physical property; polymerization; response; restoration; restorative dentistry; restorative resins; triethylene glycol dimethacrylate; uptake

DESCRIPTION (provided by applicant): In order to develop a novel restorative system with at least twice the lifetime of Bis-GMA/TEGDMA- based composites, their incomplete cure and susceptibility to hydrolysis and esterase degradation must be overcome. To address these problems, we will develop a novel superhydrophobic, degradation-resistant, dental restorative based on an Oxirane/Acrylate interpenetrating network System (OASys, pronounced Oasis). These novel monomers based on fluoridated urethanes with either dioxirane or diacrylate functionality can be highly converted to form a hydrophobic, degradation-resistant, tough and resilient interpenetrating polymer network (IPN) that is inherently highly crosslinked. By their nature, these characteristics impart low residual stresses, high resistance to hydrolytic and enzymatic degradation, and biocompatibility. We will also develop a novel one-step (primer-less), "smart," antimicrobial bonding resin with in situ-generated, colorless and color stable, silver nanoparticles (AgNPs). The bonding resin will contain a phosphate group plus both oxirane and acrylate functionalities. The oxirane and acrylate functionalities bond to the corresponding functionalities in the IPN resin matrix for potentially a much stronger bond than the conventional methacrylate system. The phosphate group will allow the bonding resin to wet etched mineral surfaces as well as bond directly to calcium in Ca-phosphate mineral structures. In the event of marginal gap formation, the "smart" in situ-generated AgNPs will release Ag+ ions and create an antibacterial environment, thereby further reducing the incidence of recurrent caries. Five specific aims are proposed: 1. To determine the effect of using oxiranes, increased hydrophobicity, and IPNs on resin mechanical properties, physical properties and in vitro biocompatibility. The more promising compositions will be combined with reinforcing filler and used for Aim 2. 2. To determine the effect of using a 4- Phospho-NPG GA oxirane (4POA)-based bonding system and in situ-generated silver nanoparticles (AgNP) on bonding resin mechanical properties, physical properties, and in vitro biocompatibility and antibacterial activit, as well as on bond strength to oxirane/acrylate interpenetrating network composites. The two best- performing composites will be chosen for subsequent aims. 3. To determine the effect of using oxiranes, increased hydrophobicity, and IPNs on resin resistance to the oral biochemical environment. The two best- performing groups chosen in Aim 2 will be fatigue- and wear-tested after exposure to acidic, basic and esterase-containing environments for 90 days. 4. To determine the effect of using oxiranes, increased hydrophobicity, and IPNs on resin resistance to bacterial degradation. The two best-performing groups from Aim 2 will be tested in an artificial mouth bacterial biofilm model. 5. To determine the in vivo biocompatibility of the OASys. The best performing OASys will be tested in three in vivo biocompatibility models: delayed-type hypersensitivity, oral mucosa irritation, and pulp and dentin response tests.

描述（由申请人提供）：为了开发一种新的修复系统，其寿命至少是Bis-GMA/TEGDMA基复合材料的两倍，必须克服其不完全固化和对水解和酯酶降解的敏感性。为了解决这些问题，我们将开发一种基于氧烷/丙烯酸酯互穿网络系统（OASys，发音为Oasis）的新型超疏水，抗降解的牙科修复材料。这些新型单体基于具有二氧环烷或二丙烯酸酯功能的氟化聚氨酯，可以高度转化成疏水、耐降解、坚韧和弹性的互穿聚合物网络（IPN），其本质上是高度交联的。就其性质而言，这些特性赋予了低残余应力、高抗水解和酶降解性以及生物相容性。我们还将开发一种新的一步（无引物）“智能”抗菌键合树脂，该树脂具有原位生成，无色且颜色稳定的银纳米粒子（AgNPs）。结合树脂将包含一个磷酸基团加上氧环烷和丙烯酸酯的功能。氧环烷和丙烯酸酯官能团与IPN树脂基体中的相应官能团结合，可能形成比传统甲基丙烯酸酯体系强得多的键合。磷酸基团将允许键合树脂湿蚀刻矿物表面，以及直接键合钙-磷酸矿物结构中的钙。在边缘间隙形成的情况下，情境生成的“智能”AgNPs会释放Ag+离子，创造抗菌环境，从而进一步降低龋齿复发的发生率。提出了五个具体目标：1。测定氧环烷、增加疏水性和ipn对树脂力学性能、物理性能和体外生物相容性的影响。更有希望的组合物将与增强填料组合并用于Aim 2。2. 研究4- Phospho-NPG GA氧环烷（4POA）键合体系与原位生成的银纳米粒子（AgNP）对键合树脂的力学性能、物理性能、体外生物相容性和抗菌活性以及氧环烷/丙烯酸酯互穿网络复合材料的键合强度的影响。将选择两种性能最好的复合材料作为后续目标。3. 测定氧环烷、增加疏水性和ipn对树脂抗口腔生化环境的影响。在目标2中选择的两个表现最好的组将在暴露于酸性、碱性和含酯酶的环境中90天后进行疲劳和磨损测试。4. 确定使用氧环烷、增加疏水性和ipn对树脂抗细菌降解的影响。Aim 2中表现最好的两组将在人工环境中进行测试