NANOFILLER DEVELOPMENT

纳米填料开发

• 批准号: 6104909
• 负责人: H. RALPH RAWLS
• 金额: $ 16.8万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-04-01 至 2000-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6104909
• 关键词: biomaterial development /preparation; composite resins; dental materials; nanotechnology; silicon compounds; tantalum

This project proposes to develop novel nanofiller resins based on tantalum oxide and silica. Our hypothesis is that the desirable properties of current microfilled resins can be retained while avoiding their major shortcomings through the development of non- aggregated nanoparticle fillers. Our overall strategy and objectives are to synthesize Ta2O5 and SiO2 nanoparticles, with varying size ranges and surface chemistries, in order to optimize four properties of resin composites: mixing rheology viscosity at high filler volume loadings to obtain satisfactory working/handling properties, toughness to resist wear and attrition, polishability and transparency to provide esthetic characteristics, and radiopacity for diagnostic utility. The rationale is that optimization can be accomplished by synthesizing filler particles that have the following properties: 100 nm or less in size to provide high polishability and avoid light scattering (thus retaining translucency)1 10 nm or more in size in order to efficiently inhibit crack-propagation (thus, enhancing wear resistance), independent and non-network forming (thus limiting viscosity buildup and allowing a high enough volume loading to toughen the structure and substantially offset polymerization shrinkage), strong interaction and coupling with acrylic matrix monomers so as to form a single phase material (thus eliminating interfacial fracture and the resulting catastrophic failure modes), and inherent radiopacity with the ability to adjust x-ray absorbance (therefore eliminating the need for hydrolysis-prone heavy-metal glass fillers and enabling radiopacity to be matched to the diagnostic requirements of the clinical application). Nanofillers with the above properties constitute a significant advance in restorative materials, independent of the other projects within the program project. Together with liquid crystal monomers and/or a dentin-inducing cavity treatment, nanofillers will form one component in a superior restorative system which can become an integral part of the dental armentarium and a viable amalgam replacement.

该项目建议开发基于纳米填料的新型纳米填料树脂 氧化钽和二氧化硅。我们的假设是理想的 可以保留当前微填充树脂的特性，同时 通过发展非 聚集的纳米颗粒填料。 我们的总体策略和目标是合成 Ta2O5 和 SiO2 纳米颗粒具有不同的尺寸范围和表面化学性质， 为了优化树脂复合材料的四个性能：混合 高填料体积负载下的流变粘度以获得 令人满意的工作/处理性能、抗磨损韧性 以及耐磨性、抛光性和透明度，以提供美观性 特性和射线不透性用于诊断用途。理由 是可以通过合成填料来实现优化 具有以下特性的颗粒：尺寸为 100 nm 或更小 提供高抛光性并避免光散射（从而保留 半透明）1 尺寸为 10 nm 或更大，以便有效抑制 裂纹扩展（从而增强耐磨性），独立且 非网络形成（从而限制粘度积累并允许 足够高的体积负载以增强结构和 大大抵消聚合收缩），强相互作用和 与丙烯酸基体单体偶联形成单相 材料（从而消除界面断裂和由此产生的 灾难性故障模式），以及固有的不透射线能力 调整 X 射线吸光度（因此无需 易于水解的重金属玻璃填料并实现射线不透性 以满足临床诊断的需要 应用）。 具有上述特性的纳米填料构成了重大进步 修复材料，独立于项目内的其他项目 计划项目。与液晶单体和/或 牙本质诱导空洞治疗，纳米填料将形成一种 高级恢复系统的组成部分，可以成为 牙科设备的组成部分和可行的汞合金 替代品。