Clinical Research and Assay Support

临床研究和检测支持

• 批准号: 8554139
• 负责人: Mary Walter
• 金额: $ 67.15万
• 依托单位: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8554139
• 关键词: Accounting; Aliquot; Biological Assay; Biological Markers; Biological Preservation; Blood; Clinical; Clinical Research; Collection; DNA; Data; Databases; Diabetes Mellitus; Endocrine; Ensure; Enteroglucagon; Genomics; Goals; Hormones; Hour; Human; Instruction; Label; Leptin; Liquid substance; Measurement; Measures; Metabolic; Methods; National Institute of Diabetes and Digestive and Kidney Diseases; Online Systems; Oxidative Stress; Plasma; Preparation; Principal Investigator; Process; Protocols documentation; Research; Research Personnel; Sampling; Services; Specimen; Statutes and Laws; System; Technology; Testing; Tube; Whole Blood; adipokines; adiponectin; biobank; cytokine; des-n-octanoyl ghrelin; ghrelin; glucagon-like peptide; programs; trend

The Clinical Research Core is responsible for processing human samples from numerous clinical studies currently in progress. Once the samples are acquired we process it according to the instructions on the protocol, aliquot, label and store the samples for the various principal investigators as per their instructions. We are currently processing an average of 900 samples/week. All samples processed in the lab are set up with a tracking number and entered into a database which is maintained by the Core lab. Studies that have started since January 2008 are labeled using a 2D-barcode system. In addition to the biorepository needs of the PIs, the Clinical Research Core also provides assay services for analyses which are currently not available at DLM. We have tested and validated numerous methods to measure total and active Glucagon-like Peptide-1, Acyl Ghrelin, Desacyl Ghrelin, Leptin, Adiponectin, Oxyntomodulin and several other markers in human plasma.

临床研究中心负责处理来自目前正在进行的众多临床研究的人体样本。 一旦获得样本，我们将根据方案中的说明对其进行处理，并根据各主要研究者的说明对样本进行等分、贴标和储存。 我们目前平均每周处理900个样品。 在实验室处理的所有样本均设置跟踪编号，并输入由核心实验室维护的数据库。自2008年1月开始的研究使用二维条形码系统进行标记。 除了PI的生物储存需求外，临床研究中心还提供DLM目前无法提供的分析服务。 我们已经测试并验证了多种方法来测量人血浆中的总的和活性胰高血糖素样肽-1、酰基生长素释放肽、去酰基生长素释放肽、瘦素、脂联素、胃泌酸调节素和几种其他标志物。