Clinical Research and Assay Support

临床研究和检测支持

• 批准号: 10008863
• 负责人: Mary Walter
• 金额: $ 192.31万
• 依托单位: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10008863
• 关键词: Accounting; Aliquot; Biological; Biological Assay; Biological Markers; Blood; Calorimetry; Clinical; Clinical Research; Collection; Data; Databases; Diabetes Mellitus; Endocrine; Ensure; Enteroglucagon; Food; Genetic screening method; Genomic DNA; Hormones; Hour; Human; Instruction; International; Label; Leptin; Liquid substance; Measurement; Measures; Metabolic; Methods; National Institute of Diabetes and Digestive and Kidney Diseases; Online Systems; Oxidative Stress; Plasma; Preparation; Principal Investigator; Process; Protocols documentation; Reproducibility; Research; Research Personnel; Sampling; Services; Ships; Site; Solid; Specimen; Statutes and Laws; System; Technology; Testing; Tube; Urine; Whole Blood; adipokines; adiponectin; biobank; cytokine; des-n-octanoyl ghrelin; ghrelin; glucagon-like peptide 1; preservation; programs; service utilization; testing services

The Clinical Research Core is responsible for processing human samples from numerous on going clinical studies as well as studies that have been completed. Once the samples are acquired we process it according to the instructions on the protocol, aliquot, label and store the samples for the various principal investigators as per their instructions. We are currently processing an average of 1200 samples/week. All samples processed in the lab are set up with a tracking number and entered into a web based database which is maintained by the Core lab. Studies that have started since January 2008 are labeled and tracked using a 2D-barcode system. The Core lab currently stores 250K human biospecimen. The Core also ships and tracks human biospecimen for the PIs within the US as well as internationally. In addition to the biorepository services, the Clinical Research Core also provides assay support for analyses which are currently not available at DLM. We have tested and validated numerous methods to measure total and active Glucagon-like Peptide-1, Acyl Ghrelin, Desacyl Ghrelin, Leptin, Adiponectin, Oxyntomodulin and several other markers in human plasma. The Clinical core also isolates genomic DNA for several studies where gDNA is required for gene testing. The lab also provides a testing service utilizing a Parr Bomb Calorimeter. The bomb calorimetry service provides a method for obtaining heats of combustion for liquid and solid samples. We are currently developing a method for calorimetric analysis of fecal, urine and food samples.

临床研究核心负责处理来自众多正在进行的临床研究以及已经完成的研究的人体样本。一旦获得样品，我们将根据方案上的说明进行处理，按照不同主要研究人员的说明对样品进行分标、标记和存储。我们目前平均每周处理1200个样品。在实验室中处理的所有样品都设置了跟踪号，并输入到由Core实验室维护的基于网络的数据库中。自2008年1月开始的研究使用2d条形码系统进行标记和跟踪。核心实验室目前储存了25万份人类生物标本。该中心还为美国以及国际上的pi运送和追踪人类生物标本。