Clinical Research and Assay Support

临床研究中心负责处理来自众多正在进行的临床研究以及已完成研究的人体样本。 一旦获得样本，我们将根据方案中的说明对其进行处理，并根据各主要研究者的说明对样本进行等分、贴标和储存。 我们目前平均每周处理1200个样品。 在实验室处理的所有样本均设置了跟踪编号，并输入由核心实验室维护的基于网络的数据库。自2008年1月开始的研究使用二维条形码系统进行标记和跟踪。核心实验室目前储存了25万人类生物标本。Core还为美国境内和国际上的PI运送和跟踪人类生物标本。 除了生物储存服务外，临床研究中心还为DLM目前无法提供的分析提供检测支持。 我们已经测试并验证了多种方法来测量人血浆中的总的和活性胰高血糖素样肽-1、酰基生长素释放肽、去酰基生长素释放肽、瘦素、脂联素、胃泌酸调节素和几种其他标志物。最近，我们增加了针对SARS-CoV-2抗体的血清学和中和试验。 临床核心还分离基因组DNA用于基因检测需要gDNA的几项研究。

The Clinical Research Core is responsible for processing human samples from numerous on going clinical studies as well as studies that have been completed. Once the samples are acquired we process it according to the instructions on the protocol, aliquot, label and store the samples for the various principal investigators as per their instructions. We are currently processing an average of 1200 samples/week. All samples processed in the lab are set up with a tracking number and entered into a web based database which is maintained by the Core lab. Studies that have started since January 2008 are labeled and tracked using a 2D-barcode system. The Core lab currently stores 250K human biospecimen. The Core also ships and tracks human biospecimen for the PIs within the US as well as internationally. In addition to the biorepository services, the Clinical Research Core also provides assay support for analyses which are currently not available at DLM. We have tested and validated numerous methods to measure total and active Glucagon-like Peptide-1, Acyl Ghrelin, Desacyl Ghrelin, Leptin, Adiponectin, Oxyntomodulin and several other markers in human plasma. Recently we have added serology and neutralization assays against antibodies to SARS-CoV-2. The Clinical core also isolates genomic DNA for several studies where gDNA is required for gene testing.