Individually tailored lighting system to improve sleep in older adults

单独定制的照明系统可改善老年人的睡眠

• 批准号: 8334919
• 负责人: Mariana Gross Figueiro
• 金额: $ 61.14万
• 依托单位: RENSSELAER POLYTECHNIC INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-01 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8334919
• 关键词: 21 year old; Adult; Adverse effects; Age; Algorithms; Body Temperature; Brain; Caregivers; Chronic; Circadian Rhythms; Clinical; Controlled Environment; Crossover Design; Data; Data Collection; Devices; Diagnosis; Early Awakening; Early Diagnosis; Effectiveness; Elderly; Environment; Exposure to; Eyelid structure; Health; Health Care Costs; Health Services Research; Home environment; Hour; Human; Independent Living; Individual; Injury; Institutes; Intervention; Laboratories; Lead; Life; Light; Lighting; Masks; Measures; Mediator of activation protein; Melatonin; Mental Depression; Methyl Green; Modality; North Carolina; Ophthalmic examination and evaluation; Optical Coherence Tomography; Outcome; Pattern; Persons; Pharmaceutical Preparations; Phase; Phototherapy; Physiological; Pilot Projects; Placebo Control; Population; Primary Insomnia; Publishing; Quality of life; Research; Research Personnel; Research Project Grants; Rest; Retina; Retinal; Risk; Safety; Sleep; Sleep Disorders; Sleep disturbances; Sleeplessness; Stimulus; System; Technology; Testing; Time; Translating; Universities; Wakefulness; Work; absorption; actigraphy; adverse outcome; aged; base; cell injury; cost; dosage; effective therapy; efficacy testing; falls; hazard; improved; light treatment; loved ones; meter; novel; practical application; prototype; sleep onset; transmission process

DESCRIPTION (provided by applicant): Impaired sleep is a common problem among older persons, and is associated with reduced daytime function, increased health care costs, increases in falls and injuries, and reduced quality of life. Pilot data from our laboratory at the Lighting Research Center (LRC) at Rensselaer Polytechnic Institute showed that monochromatic 530-nm (green) light delivered through the eyelids before predicted minimum core body temperature (CBTmin) acutely suppressed melatonin and delayed dim light melatonin onset (DLMO). Based on our newly published data on eyelid transmittance, we propose to, in conjunction with investigators at the University of North Carolina at Chapel Hill, test the efficac and acceptance of a device developed to effectively deliver light to phase delay the timing of sleep in older persons with chronic early awakening insomnia, and to assess the effectiveness, acceptance, and safety of this device in the home environment. The light treatment device will have three components: 1) a personal circadian light meter, the Dimesimeter, to collect circadian light/dark and activity/rest patterns; 2) an algorithm to identify the most effective timng to apply circadian light; and 3) a light mask, to deliver 530-nm (green) light during sleep. For Aim 1, we will field test and study the use of this device in 20 older adults with diagnoses of early morning awakenings, and 20 age-matched control subjects. In Aim 2, we will study the use of this device in the home environments of 32 older adults with chronic early awakening insomnia. Because circadian sleep disorders in older adults are one of the primary reasons why caregivers choose to institutionalize their loved ones, a lighting intervention that could improve sleep quality and reduce insomnia in older adults could also potentially delay the transition of older adults to a controlled living environment. Therefore, this project is well-suited for the framework of the PA-11-020 - Technology for Healthy Independent Living Research Grants. Successful introduction of this novel device into clinical settings could lead to the implementation of an economical, non-pharmacological, simple treatment modality that alleviates the adverse consequences associated with early awakening insomnia. PUBLIC HEALTH RELEVANCE: Impaired sleep is a common problem among older persons, and is associated with reduced daytime function, increased health care costs, increases in falls and injuries, and reduced quality of life. It is estimated that 48% of adults aged 60 and older have difficulty falling asleep and/or maintaining sleep, and there is a lack of safe and effective therapy. We will test a non-pharmacological treatment device to alleviate the adverse consequences of early awakening insomnia.

描述（由申请人提供）：睡眠受损是老年人的常见问题，与白天功能下降、医疗费用增加、跌倒和受伤增加以及生活质量下降有关。我们实验室的试验数据