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Reactive Oxygen Species Core

Reactive Oxygen Species Core
活性氧核心
批准号：
8380238
负责人：
Sergey Dikalov
金额：
$17.07万
依托单位：
EMORY UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/8380238
关键词：
BiologicalBlood VesselsCellsCollaborationsCore FacilityCysteineElectron Spin Resonance SpectroscopyGlutathione DisulfideHydrogen PeroxideIn VitroIndividualInflammationLaboratoriesLiquid ChromatographyMeasurementModificationOxidation-ReductionParticipantPreparationProcessProteinsProtocols documentationReactive Oxygen SpeciesReduced GlutathioneResearch PersonnelRoleSamplingSuperoxidesTissue membraneTissuesTrainingValidationVascular DiseasesWorknanoprograms

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中文摘要
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英文摘要
The purpose of Core C is to provide state-of-the-art measurements of reactive oxygen species (ROS), reduced glutathione (GSH), glutathione disulfide (GSSG), oxidative modifications of cysteine residues of redox-sensitive proteins in cells, tissues and membranes for participants of the PPG. Core C will assist with preparation and processing of various biological samples for analysis using Electron Spin Resonance (ESR) spectroscopy, High Perfonnance Liquid Chromatography (HPLC) and nano-LC MS/MS analysis. This Core facility has existed since 1999 and has supported numerous studies of superoxide (O2*), hydrogen peroxide (H2O2) and NO in vascular cells and tissue, and it was an essential part of the previous program project studies by Drs. Harrison, Griendling, Taylor and Jo (1-10). This facility will significantly enhance the work of the individual laboratories. and will enhance collaborations between participants of the PPG
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