MSM and Substances Cohort at UCLA Linking Infections Noting Effects (MASCULINE)

加州大学洛杉矶分校的 MSM 和物质队列将感染注意影响联系起来（男性）

• 批准号: 8850993
• 负责人: Pamina Mae Gorbach
• 金额: $ 0.9万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-30 至 2018-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8850993
• 关键词: AIDS prevention; AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Adherence; Advisory Committees; Affect; Age; Alcohol or Other Drugs use; Amphetamines; Anti-Retroviral Agents; Anus; Archives; Basic Science; Behavior; Behavioral; Biological; Biological Testing; Biopsy; Blood; CD4 Positive T Lymphocytes; California; Caring; Chlamydia; Cohort Studies; Communicable Diseases; Communities; County; Crack Cocaine; Data; Drug usage; Drug user; Epidemic; Epidemiology; Fostering; Gonorrhea; HIV; HIV Infections; HIV Seropositivity; HIV risk; HIV therapy; HIV-1; HIV/STD; Health; Health Insurance Portability and Accountability Act; Hepatitis C; Hepatitis C virus; Heroin; High Prevalence; Hispanics; Immune; Immunology; Improve Access; Incidence; Individual; Infection; Inflammatory; Inflammatory Response; Injecting drug user; Knowledge; Lead; Link; Liquid substance; Los Angeles; Measurable; Methamphetamine; Minority; Mucositis; Mucous Membrane; National Institute of Allergy and Infectious Disease; National Institute of Drug Abuse; Pathogenesis; Pattern; Pharmaceutical Preparations; Plasma; Population; Predisposition; Prevalence; Prevention; Public Health; Recording of previous events; Recruitment Activity; Research; Research Infrastructure; Research Personnel; Risk; Risk Behaviors; Sampling; Science; Sexual Transmission; Sexually Transmitted Diseases; Source; Specimen; Substance abuse problem; Syphilis; Tissues; Treatment Protocols; Universities; Viral Load result; Visit; Work; base; biobank; clinically relevant; cohort; comparative; cytokine; ecstasy; high risk; immune function; innovation; mathematical model; medication compliance; member; men who have sex with men; non-drug; novel; rectal; repository; response; sexually active; transmission process; treatment adherence

DESCRIPTION (provided by applicant): This application in response to NIDA PAR 12-222 Cohort Studies of HIV/AIDS and Substance Use (U01) seeks to leverage extensive existing infrastructure and cohorts at the University of California, Los Angeles to launch a new cohort of substance using minority (Black or Hispanic) men who have sex with men (MMSM). The epidemic of HIV among MMSM in the US and locally in Los Angeles County (LAC) may be driven by effects of substance use on adherence to treatment regimens and bio-behavioral prevention and enhanced by high prevalence networks. Proposed investigators lead the science on studying associations between non-injection drug use, risk behaviors and infectious disease among MSM, and contribute a broad portfolio of inter-disciplinary work from immunology and basic science to epidemiology, prevention and treatment. The work proposed leverages existing cohorts including the Multicenter AIDS Cohort (MACS) and existing repositories and builds on preliminary work to guide assembly of a cohort for the study of basic and behavioral factors in younger MMSM who actively use substances and engage transmission risks. Establishing a cohort of young active substance users, particularly stimulant users, who have poor histories of antiretroviral treatment (ART) adherence as marked by measurable and clinically relevant Plasma Viral Load (PVL) will enable important tests of biological influences of substances on immune function in MMSM. This cohort is central to prevention and treatment efforts and will provide well-characterized, extensive repository samples for leveraged use with other cohorts, networks' and individual's studies. The MMSM will be: (i) HIV-positive with viral load >5000 copies/ml or (ii) HIV-negative at high risk for HIV infection (unprotected anal intercourse in the past 6 months). This unique cohort will facilitate studies on interactions between substance use and HIV progression and/or transmission, which are of critical public health significance. This cohort of MMSM will characterize: (i) effects substance use on behavioral and network level risk in exposed and infected MMSM on acquisition of HIV and other sexually transmitted infections (STIs: gonorrhea, Chlamydia, syphilis, Hepatitis C (HCV)); and (ii) the extent to which substance use in MMSM facilitates behaviors that transmit HIV compared to non-drug using MMSM. The application also proposes to develop and maintain a bio repository that is HIPAA-compliant, technologically-current and DAIDS Network interfaced that includes a scientific advisory committee. This cohort will comprise 620 MMSM with repeated data visits (from 1,080 MMSM). At least half of these MMSM will be active substance users and younger than age 30.

描述（由申请人提供）：本申请响应NIDA PAR 12-222艾滋病毒/艾滋病和药物使用队列研究（U01），旨在利用加州大学洛杉矶分校广泛的现有基础设施和队列，启动一个新的药物使用少数族裔（黑人或西班牙裔）男性与男性发生性关系（MMSM）的队列。在美国和洛杉矶县（LAC）当地的男男性接触者中艾滋病毒的流行可能是由药物使用对治疗方案的依从性和生物行为预防的影响驱动的，并由高流行网络增强。在研究非注射药物使用、危险行为和MSM传染病之间的关系方面，研究人员处于科学领先地位，并在免疫学和基础科学、流行病学、预防和治疗等跨学科领域做出了广泛的贡献。建议的工作利用现有的队列，包括多中心艾滋病队列（MACS）和现有的存储库，并建立在初步工作的基础上，指导队列的组装，以研究积极使用药物并参与传播风险的年轻MMSM的基本和行为因素。建立一个年轻的活性物质使用者，特别是兴奋剂使用者的队列，他们的抗逆转录病毒治疗（ART）依从性较差，这是可测量的和临床相关的血浆病毒载量（PVL）的标志，将使物质对MMSM免疫功能的生物学影响的重要测试成为可能。该队列是预防和治疗工作的核心，并将为其他队列、网络和个人研究提供特征明确、广泛的存储样本。MMSM将：(i) HIV阳性，病毒载量为5000拷贝/毫升或（ii） HIV阴性，HIV感染风险高（过去6个月内无保护肛交）。这一独特的队列将促进药物使用与艾滋病毒进展和/或传播之间相互作用的研究，这对公共卫生具有重要意义。该MMSM队列将具有以下特征：(i)暴露和感染MMSM的行为和网络层面风险对物质使用的影响：感染HIV和其他性传播感染（性传播感染：淋病、衣原体、梅毒、丙型肝炎）；（ii）与不使用药物的男男性接触者相比，男男性接触者的药物使用在多大程度上促进了传播艾滋病毒的行为。该申请还建议开发和维护一个生物资源库，该资源库符合hipaa标准，具有最新的技术，并且与DAIDS网络接口，其中包括一个科学咨询委员会。该队列将包括620名MMSM，重复数据访问（来自1,080名MMSM）。这些MMSM中至少有一半是活跃的药物使用者，年龄小于30岁。