Collaborating Consortium of Cohorts Producing NIDA Opportunities (C3PNO)

产生 NIDA 机会的群体合作联盟 (C3PNO)

• 批准号: 10165380
• 负责人: Pamina Mae Gorbach
• 金额: $ 32.61万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-05-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10165380
• 关键词: 2019-nCoV; AIDS prevention; Address; Adherence; Administrative Supplement; Adolescent Medicine Trials Network; Affect; Alcohol or Other Drugs use; Anxiety; Appointment; Area; Baltimore; Behavior; COVID-19; COVID-19 pandemic; Cannabis; Caring; Chicago; Cities; Cohort Studies; Collection; Communities; Continuity of Patient Care; Counseling; Data; Drug usage; Family; Food; Frequencies; Funding; Funding Opportunities; HIV; HIV Infections; HIV Seronegativity; HIV Seropositivity; HIV prevention trials network; Health; Height; Home environment; Housing; Individual; Infrastructure; Injections; Interruption; Link; Los Angeles; Measures; Medical Records; Mental Health; Methamphetamine; NIH Program Announcements; National Institute of Drug Abuse; North America; Opioid; Participant; Patient Self-Report; Pharmaceutical Preparations; Population; Population Group; Prevalence; Prevention; Research; Risk Factors; Science; Smoking; Social isolation; Specific qualifier value; Substance Use Disorder; Surveys; Time; Tobacco; Vulnerable Populations; addiction; antiretroviral therapy; base; cohort; data harmonization; design; experience; food insecurity; frontier; high risk; innovation; interest; intimate partner violence; marijuana vaping; neurodevelopment; novel; opioid use disorder; pre-exposure prophylaxis; prescription opioid; public health emergency; response; social; stimulant use; vaping; young men who have sex with men

ABSTRACT In response to the Notice of Special Interest (NOSI) regarding the Availability of Administrative Supplements and Urgent Competitive Revisions for Research on the 2019 Novel Coronavirus (Notice Number NOT-DA-20-047 and linked Program Announcement PA-18-591) funding opportunity, the Collaborating Consortium of Cohorts Producing NIDA Opportunities (C3PNO; U24DA044554) proposes a project to assess the impact of COVID-19 on the participating cohorts' population of substance-using people living with HIV (PLWH) and those at high-risk for HIV infection. Our innovative study proposes to collect data from a subset of participants from each of seven participating C3PNO cohorts at two time points – in the height of the COVID-19 pandemic and during its mitigation and control – in order to assess the impact of the COVID-19 epidemic on substance use for PLWH and those at high risk for HIV. We will use our current infrastructure and C3PNO validated harmonization strategies to compile new and existing data across the cohorts in order to: assess changes in social and individual determinants of health during the course of the COVID-19 pandemic, to estimate differences in substance-using behaviors of those who were confirmed/probable cases of COVID-19 (based on self-report or medical record) and those who were not a confirmed/probable case, and to assess how PLWH and people who are at high risk for HIV in C3PNO have different experiences in and responses to the COVID-19 epidemic as compared to other HIV studies and cohorts that have less substance use. The C3PNO Coordinating Center at UCLA and Frontier Science will facilitate the design and implementation of a survey to collect data from a subset of participants from each of seven participating C3PNO cohorts (ALIVE, HYM, JHHCC, MASH, mSTUDY, RADAR, and V-DUS). Participating cohorts will issue the survey to participants and transfer the resulting data to the coordinating center. If funded, this administrative supplement would allow a rapid and coordinated collection of linked COVID-19, HIV, and substance use data related to an ongoing public health emergency affecting the highly vulnerable substance-using populations followed by the cohorts. COVID-19 data harmonization with other HIV cohorts will further aide our collective effort to understand the impact of COVID-19 on HIV impacted communities. Finally, C3PNO's effort to assess changes in social and individual determinants of health during the course of the COVID-19 pandemic as well as estimate differences in substance-using behaviors and the impact on PLWH or at high risk for HIV is both novel and critical in this time of unprecedented social upheaval and instability.

摘要 回应特别关注(NOSI)关于提供行政补充和 2019年新型冠状病毒研究的紧急竞争性修订(通告编号NOT-DA-20-047 和链接的计划公告PA-18-591)Funding Opportunity，群组协作联盟 《创造NIDA机遇》(C3PNO；U24DA044554)提出了一个项目来评估新冠肺炎的影响 艾滋病病毒携带者和高危人群中吸毒人群的研究 用于艾滋病病毒感染。我们的创新研究建议从七位参与者中的每一位收集数据 在两个时间点参与C3PNO队列-在新冠肺炎大流行的高峰期和在 缓解和控制--以评估新冠肺炎疫情对公共卫生部门物质使用的影响 以及那些感染艾滋病毒的高危人群。我们将使用我们当前的基础设施和C3PNO验证的协调性 在各队列中汇编新的和现有数据的战略，以便：评估社会和经济方面的变化 新冠肺炎大流行期间的个人健康决定因素，以估计 新冠肺炎确诊/疑似病例患者的药物使用行为(基于自我报告或 医疗记录)和那些不是确诊/可能病例的人，并评估公共卫生部门和那些 C3PNO中艾滋病毒高危人群在新冠肺炎疫情中的经历和应对方式不同， 与其他使用较少物质的艾滋病毒研究和队列相比。C3PNO协调中心位于 加州大学洛杉矶分校和前沿科学将促进设计和实施一项从子集收集数据的调查 来自七个参与C3PNO队列的参与者(Alive、HYM、JHCC、MASH、MSTUDY、 雷达和V-DUS)。参与的队列将向参与者发布调查并传输结果数据 去协调中心。如果得到资金，这一行政补充将允许快速和协调 收集与正在进行的突发公共卫生事件相关的新冠肺炎、艾滋病毒和药物使用数据 影响到高度脆弱的药物使用人群，然后是队列。新冠肺炎数据 与其他艾滋病毒队列的协调将进一步有助于我们了解新冠肺炎的影响的集体努力 关于受艾滋病毒影响的社区。最后，C3PNO努力评估社会和个人决定因素的变化 新冠肺炎大流行期间的健康状况以及估计物质使用方面的差异 在这个史无前例的时代，行为及其对PLWH或艾滋病毒高危人群的影响既是新的，也是关键的 社会动乱和不稳定。