Collaborating Consortium of Cohorts Producing NIDA Opportunities (C3PNO)

摘要 作为对RFA-DA-17-019的回应，我们建议为NIDA队列建立一个协调中心， “C3NPO”* 管理和鼓励使用生成的数据 解决艾滋病毒/艾滋病的高度优先研究问题 在滥用药物的情况下。我们的重点是尖端科学， 样本量约为12，500名参与者。我们汇集了一个研究团队， 在物质使用，艾滋病毒预防，临床科学和共病，免疫学，建模，和 生物伦理学与NIDA计划科学家合作，促进NIDA资助的最高影响力科学 这些群体汇编了各种丰富数据的独特储存库。我们的提案独特地结合了 学术和专业研究管理专业知识，将刺激，管理和支持科学 协作我们将使内部和外部研究人员能够在新的研究中培养这些队列的数据。 创新的科学方向。我们的生物信息学能力在标本领域是独一无二的强大 管理，开发了行业黄金标准软件，将大大促进共享 所有的样本。我们的领导将NIDA的利益与以下方面的观点和关切联系起来： 由队列PI/研究科学家（Pamina Gorbach，加州大学，洛杉矶） 与经验丰富的HIV网络生物信息学管理负责人（Suzanne Siminski，Frontier 科学技术研究基金会。我们将利用其他资助的研究计划， 尽管NIDA等外部科学咨询委员会（ESAB）支持协调措施的努力 用于物质使用研究，并将其与数据链接策略联合收割机相结合。我们得到了所有人的支持 队列PI，联盟领导层最好由另一个队列PI领导，以加强团队科学和支持 作为我们的领导者。这个提议团队的合作性质提供了新的潜力， 生物信息学技术的发展，允许整合不同的和越来越大规模的集合， 行为、临床和实验室数据，供队列和外部研究人员使用。因此，我们的建议将 解决NIDA 2016-2020战略计划的重点领域和交叉主题 （https：//www.drugabuse.gov/about-nida/2016-2020-nida-strategic-plan）通过利用技术， 创新，促进合作，鼓励数据和资源共享。战略将发展 基础设施，允许跨学科，大规模的分析，导致艾滋病毒科学的最高影响， 物质使用。

ABSTRACT In response to RFA-DA-17-019 we propose to establish a Coordinating Center for the NIDA Cohorts entitled “C3NPO” * to manage and stimulate use of the data generated to address high priority research on HIV/AIDS in the context of substance abuse. Our focus is cutting-edge science powered by the cohorts' combined sample size of approximately 12,500 participants. We bring together a team of researchers with global leadership in substance use, HIV prevention, clinical science and co-morbidities, immunology, modeling, and bioethics to work with NIDA program scientists to stimulate the highest impact science across NIDA-funded cohorts that have compiled unique repositories of varied and rich data. Our proposal uniquely combines academic and professional research management expertise that will stimulate, manage, and support scientific collaboration. We will enable internal and external investigators to cultivate the data from these cohorts in new and innovative scientific directions. Our bioinformatics capacity is uniquely strong in the area of specimen management, having developed the industry gold standard software that will greatly facilitate sharing of specimens across the cohorts. Our leadership bridges NIDA's interests with the perspectives and concerns of the cohorts by having a cohort PI/research scientist (Pamina Gorbach, University of California, Los Angeles) partnered with an experienced HIV network bioinformatics management leader (Suzanne Siminski, Frontier Science & Technology Research Foundation (FSTRF). We will leverage other funded research initiatives though our External Scientific Advisory Board (ESAB) such as NIDA-supported efforts to harmonize measures for substance use research and combine that with data linking strategies. We have the endorsement of all cohort PIs that Consortium leadership is best led from another cohort PI to enhance team science and support for our team as the leaders. The collaborative character of this proposing team offers the potential for new developments in bioinformatics techniques that allow integration of diverse and ever more massive sets of behavioral, clinical, and laboratory data for use by cohort and outside researchers. Thus, our proposal will address NIDA's 2016-2020 Strategic Plan priority focus areas and cross-cutting themes (https://www.drugabuse.gov/about-nida/2016-2020-nida-strategic-plan) by leveraging technology, driving innovation, promoting collaboration, and encouraging data and resource sharing. The strategy will develop infrastructure that allows cross-disciplinary, large-scale analyses leading to the highest impact HIV science on substance use.