Collaborating Consortium of Cohorts Producing NIDA Opportunities (C3PNO)

产生 NIDA 机会的群体合作联盟 (C3PNO)

• 批准号: 10552117
• 负责人: Pamina Mae Gorbach
• 金额: $ 51.07万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-05-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10552117
• 关键词: AIDS prevention; AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Address; Area; Automobile Driving; Behavioral; Bioethics; Bioinformatics; Biological Specimen Banks; Biometry; California; Catalogs; Clinical; Clinical Research; Clinical Sciences; Clinical Trials Network; Collaborations; Common Data Element; Computer software; Data; Data Collection; Data Linkages; Data Management Resources; Data Set; Data Sources; Data Store; Databases; Development; Ethics; Foundations; Funding; Gold; HIV; HIV prevention trials network; Immunology; Individual; Industry; Infrastructure; Laboratories; Lead; Leadership; Letters; Link; Logistics; Longitudinal cohort; Los Angeles; Measurement; Measures; Methodology; Methods; Modeling; National Institute of Drug Abuse; Online Systems; Outcome Measure; Participant; Patient Outcomes Assessments; Performance; Procedures; Process; Recording of previous events; Research; Research Personnel; Research Priority; Research Project Grants; Resource Sharing; Resources; Sample Size; Science; Scientist; Site; Specimen; Standardization; Strategic Planning; Study models; Substance abuse problem; System; Technical Expertise; Techniques; Technology; Translating; United States National Institutes of Health; Universities; Work; biobank; bioinformatics network; cohort; comorbidity; data harmonization; data sharing; diverse data; epidemiology study; experience; flexibility; frontier; innovation; instrument; interest; meetings; member; programs; repository; response; substance use; tool; virtual; webinar; working group

ABSTRACT In response to RFA-DA-17-019 we propose to establish a Coordinating Center for the NIDA Cohorts entitled “C3NPO” * to manage and stimulate use of the data generated to address high priority research on HIV/AIDS in the context of substance abuse. Our focus is cutting-edge science powered by the cohorts' combined sample size of approximately 12,500 participants. We bring together a team of researchers with global leadership in substance use, HIV prevention, clinical science and co-morbidities, immunology, modeling, and bioethics to work with NIDA program scientists to stimulate the highest impact science across NIDA-funded cohorts that have compiled unique repositories of varied and rich data. Our proposal uniquely combines academic and professional research management expertise that will stimulate, manage, and support scientific collaboration. We will enable internal and external investigators to cultivate the data from these cohorts in new and innovative scientific directions. Our bioinformatics capacity is uniquely strong in the area of specimen management, having developed the industry gold standard software that will greatly facilitate sharing of specimens across the cohorts. Our leadership bridges NIDA's interests with the perspectives and concerns of the cohorts by having a cohort PI/research scientist (Pamina Gorbach, University of California, Los Angeles) partnered with an experienced HIV network bioinformatics management leader (Suzanne Siminski, Frontier Science & Technology Research Foundation (FSTRF). We will leverage other funded research initiatives though our External Scientific Advisory Board (ESAB) such as NIDA-supported efforts to harmonize measures for substance use research and combine that with data linking strategies. We have the endorsement of all cohort PIs that Consortium leadership is best led from another cohort PI to enhance team science and support for our team as the leaders. The collaborative character of this proposing team offers the potential for new developments in bioinformatics techniques that allow integration of diverse and ever more massive sets of behavioral, clinical, and laboratory data for use by cohort and outside researchers. Thus, our proposal will address NIDA's 2016-2020 Strategic Plan priority focus areas and cross-cutting themes (https://www.drugabuse.gov/about-nida/2016-2020-nida-strategic-plan) by leveraging technology, driving innovation, promoting collaboration, and encouraging data and resource sharing. The strategy will develop infrastructure that allows cross-disciplinary, large-scale analyses leading to the highest impact HIV science on substance use.

摘要