Collaborating Consortium of Cohorts Producing NIDA Opportunities (C3PNO) Second Bridge Funding Supplement

产生 NIDA 机会的队列合作联盟 (C3PNO) 第二桥资金补充

• 批准号: 10609365
• 负责人: Pamina Mae Gorbach
• 金额: $ 49.03万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-05-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10609365
• 关键词: AIDS prevention; AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Address; Area; Automobile Driving; Behavioral; Bioethics; Bioinformatics; Biological Specimen Banks; Biometry; California; Catalogs; Clinical; Clinical Research; Clinical Sciences; Clinical Trials Network; Collaborations; Common Data Element; Computer software; Data; Data Collection; Data Linkages; Data Management Resources; Data Set; Data Sources; Data Store; Databases; Development; Ethics; Foundations; Funding; Gold; HIV; HIV prevention trials network; Immunology; Individual; Industry; Infrastructure; Laboratories; Lead; Leadership; Letters; Link; Logistics; Longitudinal cohort; Los Angeles; Measurement; Measures; Methodology; Methods; Modeling; National Institute of Drug Abuse; Online Systems; Outcome Measure; Participant; Patient Outcomes Assessments; Performance; Procedures; Process; Recording of previous events; Research; Research Personnel; Research Priority; Research Project Grants; Resource Sharing; Resources; Sample Size; Science; Scientist; Site; Specimen; Standardization; Strategic Planning; Study models; Substance abuse problem; System; Technical Expertise; Techniques; Technology; Translating; United States National Institutes of Health; Universities; Work; biobank; bioinformatics network; cohort; comorbidity; data harmonization; data sharing; diverse data; epidemiology study; experience; flexibility; frontier; innovation; instrument; interest; meetings; member; programs; repository; response; substance use; tool; virtual; webinar; working group

ABSTRACT In response to RFA-DA-17-019 we propose to establish a Coordinating Center for the NIDA Cohorts entitled “C3NPO” * to manage and stimulate use of the data generated to address high priority research on HIV/AIDS in the context of substance abuse. Our focus is cutting-edge science powered by the cohorts' combined sample size of approximately 12,500 participants. We bring together a team of researchers with global leadership in substance use, HIV prevention, clinical science and co-morbidities, immunology, modeling, and bioethics to work with NIDA program scientists to stimulate the highest impact science across NIDA-funded cohorts that have compiled unique repositories of varied and rich data. Our proposal uniquely combines academic and professional research management expertise that will stimulate, manage, and support scientific collaboration. We will enable internal and external investigators to cultivate the data from these cohorts in new and innovative scientific directions. Our bioinformatics capacity is uniquely strong in the area of specimen management, having developed the industry gold standard software that will greatly facilitate sharing of specimens across the cohorts. Our leadership bridges NIDA's interests with the perspectives and concerns of the cohorts by having a cohort PI/research scientist (Pamina Gorbach, University of California, Los Angeles) partnered with an experienced HIV network bioinformatics management leader (Suzanne Siminski, Frontier Science & Technology Research Foundation (FSTRF). We will leverage other funded research initiatives though our External Scientific Advisory Board (ESAB) such as NIDA-supported efforts to harmonize measures for substance use research and combine that with data linking strategies. We have the endorsement of all cohort PIs that Consortium leadership is best led from another cohort PI to enhance team science and support for our team as the leaders. The collaborative character of this proposing team offers the potential for new developments in bioinformatics techniques that allow integration of diverse and ever more massive sets of behavioral, clinical, and laboratory data for use by cohort and outside researchers. Thus, our proposal will address NIDA's 2016-2020 Strategic Plan priority focus areas and cross-cutting themes (https://www.drugabuse.gov/about-nida/2016-2020-nida-strategic-plan) by leveraging technology, driving innovation, promoting collaboration, and encouraging data and resource sharing. The strategy will develop infrastructure that allows cross-disciplinary, large-scale analyses leading to the highest impact HIV science on substance use.

摘要 响应RFA-DA-17-019，我们建议为NIDA群组建立一个协调中心，名为 “C3NPO”* 管理和鼓励使用所生成的数据 处理艾滋病毒/艾滋病的高度优先研究 在滥用药物的情况下。我们的重点是尖端科学，由这些队列的组合提供支持 样本大小约为12,500名参与者。我们汇集了一支研究团队，与全球 在物质使用、艾滋病毒预防、临床科学和共病、免疫学、建模和 生物伦理学将与NIDA计划的科学家合作，在NIDA资助的范围内刺激影响最大的科学 已经汇编了各种丰富数据的独特储存库的队列。我们的提案独特地结合了 学术和专业研究管理专业知识，将刺激、管理和支持科学研究 协作。我们将使内部和外部调查人员能够在新的环境中培养这些队列的数据 和创新的科学方向。我们的生物信息学能力在标本领域是独一无二的 管理层，开发了行业黄金标准软件，将极大地促进共享 队列中的样本。我们的领导层将NIDA的利益与以下方面的观点和关切联系起来 由一名PI/研究科学家组成的队列(帕米娜·戈尔巴赫，加州大学洛杉矶分校) 与经验丰富的艾滋病毒网络生物信息学管理负责人合作(Suzanne Siminski，Frontier 科技研究基金会(FSTRF)我们将利用其他资助的研究计划。 尽管我们的外部科学咨询委员会(ESAB)，如NIDA-支持协调措施的努力 用于物质使用研究，并将其与数据链接战略结合起来。我们得到了所有人的支持 群组PI认为联盟领导层最好由另一个群组PI领导，以增强团队的科学性和支持 作为领头羊的我们的团队。该提议团队的协作特性提供了新的潜力 生物信息学技术的发展，允许整合不同的和更大规模的集合 供队列和外部研究人员使用的行为、临床和实验室数据。因此，我们的建议将 处理NIDA 2016-2020年战略计划的优先重点领域和交叉主题 (https://www.drugabuse.gov/about-nida/2016-2020-nida-strategic-plan)通过利用技术，推动 创新，促进协作，鼓励数据和资源共享。这一战略将得到发展 基础设施，允许进行跨学科的大规模分析，从而使艾滋病毒科学对 物质使用。

项目成果

Changes in secondary substance use after the onset of the COVID-19 pandemic among people who use cannabis: Findings from a web-based sample of adults in the United States.

• DOI: 10.1037/pha0000572
• 发表时间: 2023-04
• 期刊: EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY
• 影响因子: 2.3
• 作者: Lake, Stephanie;Assaf, Ryan D.;Gorbach, Pamina M.;Cooper, Ziva D.
• 通讯作者: Cooper, Ziva D.

COVID-19 Testing and the Impact of the Pandemic on the Miami Adult Studies on HIV Cohort.

• DOI: 10.1097/qai.0000000000002680
• 发表时间: 2021-08-01
• 期刊: Journal of acquired immune deficiency syndromes (1999)
• 作者: Tamargo JA;Martin HR;Diaz-Martinez J;Trepka MJ;Delgado-Enciso I;Johnson A;Mandler RN;Siminski S;Gorbach PM;Baum MK
• 通讯作者: Baum MK

Resilience, Anxiety, Stress, and Substance Use Patterns During COVID-19 Pandemic in the Miami Adult Studies on HIV (MASH) Cohort.

• DOI: 10.1007/s10461-021-03292-y
• 发表时间: 2021-11
• 期刊: AIDS and behavior
• 影响因子: 4.4
• 作者: Diaz-Martinez J;Tamargo JA;Delgado-Enciso I;Liu Q;Acuña L;Laverde E;Barbieri MA;Trepka MJ;Campa A;Siminski S;Gorbach PM;Baum MK
• 通讯作者: Baum MK

Stress Increases the Association between Cigarette Smoking and Mental Disorders, as Measured by the COVID-19-Related Worry Scale, in the Miami Adult Studies on HIV (MASH) Cohort during the Pandemic.

• DOI: 10.3390/ijerph19138207
• 发表时间: 2022-07-05
• 期刊: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
• 作者: Diaz-Martinez, Janet;Delgado-Enciso, Ivan;Campa, Adriana;Tamargo, Javier A.;Martin, Haley R.;Johnson, Angelique;Siminski, Suzanne;Gorbach, Pamina M.;Baum, Marianna K.
• 通讯作者: Baum, Marianna K.

Comparing single and multiple imputation strategies for harmonizing substance use data across HIV-related cohort studies.

• DOI: 10.1186/s12874-022-01554-4
• 发表时间: 2022-04-03
• 期刊: BMC medical research methodology
• 影响因子: 4
• 作者: Javanbakht M;Lin J;Ragsdale A;Kim S;Siminski S;Gorbach P
• 通讯作者: Gorbach P