Collaborating Consortium of Cohorts Producing NIDA Opportunities (C3PNO)

摘要 回应特别关注(NOSI)关于提供行政补充和 2019年新型冠状病毒研究的紧急竞争性修订(通告编号NOT-DA-20-047 和链接的计划公告PA-18-591)Funding Opportunity，群组协作联盟 Producing NIDA Opportunities(C3PNO；U24DA044554)建议评估新冠肺炎对 参与队列-包括吸毒者(PWUD)、艾滋病毒携带者(PLWH)和 感染艾滋病毒的高危人群。我们建议扩展C3PNO新冠肺炎模块，该模块是在以前的 补充(4U24DA044554-03：S2)，包括疫苗接种态度、接种率和依从性以及接种后 新冠肺炎的症状和证候。新单元将允许对实践进行进一步的纵向评估 C3PNO队列中的防护行为、测试、物质使用和精神健康至少再进行两次 每隔六个月进行一次查房，得出两年的新冠肺炎大流行经验相关数据。这种方法 将使我们能够纵向评估疫苗接种的犹豫不决/可接受性和结构性因素与 接受和坚持接种新冠肺炎疫苗。此外，我们将使用我们现有的基础设施和C3PNO 经过验证的协调战略，以汇编各队列中新的和现有的数据，以便： 新冠肺炎大流行期间社会和个人健康决定因素的变化，以估计 新冠肺炎确诊/疑似病例患者的物质使用行为差异(根据 自我报告或医疗记录)和那些不是确诊/可能病例的人，并评估PLWH和 C3PNO中艾滋病毒高危人群对新冠肺炎的经历和反应不同 流行病。加州大学洛杉矶分校(UCLA)和前沿的C3PNO协调中心 科学将促进调查的设计和实施，以从以下方面收集参与者的数据 每个C3PNO队列(Access、Alive、心脏研究、HYM、JHHCC、MASH、mSTUDY、雷达和V- DU)。队列将向参与者发布调查，并将结果数据传输到协调中心。如果 在资金的资助下，这一行政补编将允许快速和协调地收集与新冠肺炎、艾滋病毒、 以及与正在发生的影响高度脆弱物质的公共卫生紧急情况有关的物质使用数据- 使用的是种群，然后是队列。新冠肺炎与其他艾滋病毒队列的数据协调将进一步帮助 我们共同努力，了解新冠肺炎对这些高危社区的影响。最后，C3PNO的努力 评估社会和个人健康决定因素的变化，疫苗态度，物质差异- 在新冠肺炎大流行期间，使用行为和影响艾滋病毒感染者既是 在这个史无前例的社会动荡和不稳定的时代，这是一种新颖而具有批判性的作品。

ABSTRACT In response to the Notice of Special Interest (NOSI) regarding the Availability of Administrative Supplements and Urgent Competitive Revisions for Research on the 2019 Novel Coronavirus (Notice Number NOT-DA-20-047 and linked Program Announcement PA-18-591) funding opportunity, the Collaborating Consortium of Cohorts Producing NIDA Opportunities (C3PNO; U24DA044554) proposes to assess the impact of COVID-19 on the participating cohorts - including people who use drugs (PWUD), people living with HIV (PLWH), and those at high-risk for HIV infection. We propose to expand the C3PNO COVID-19 module developed under a previous supplement (4U24DA044554-03:S2) to include vaccination attitudes, uptake, and adherence as well as post- COVID-19 symptoms and syndrome. The new module will allow further longitudinal assessment of the practice of protective behaviors, testing, substance use, and mental health in the C3PNO cohorts for at least two more rounds six months apart resulting in two years of data related to COVID-19 pandemic experiences. This approach will allow us to longitudinally assess vaccination hesitancy/acceptability and structural factors' association with uptake and adherence to COVID-19 vaccination. Additionally, we will use our current infrastructure and C3PNO validated harmonization strategies to compile new and existing data across the cohorts in order to: assess changes in social and individual determinants of health during the course of the COVID-19 pandemic, to estimate differences in substance-using behaviors of those who were confirmed/probable cases of COVID-19 (based on self-report or medical record) and those who were not a confirmed/probable case, and to assess how PLWH and people who are at high risk for HIV in C3PNO have different experiences in and responses to the COVID-19 epidemic. The C3PNO Coordinating Center at The University of California, Los Angeles (UCLA) and Frontier Science will facilitate the design and implementation of a survey to collect data from a subset of participants from each of C3PNO cohorts (ACCESS, ALIVE, the Heart Study, HYM, JHHCC, MASH, mSTUDY, RADAR, and V- DUS). Cohorts will issue the survey to participants and transfer the resulting data to the coordinating center. If funded, this administrative supplement would allow a rapid and coordinated collection of linked COVID-19, HIV, and substance use data related to an ongoing public health emergency affecting the highly vulnerable substance- using populations followed by the cohorts. COVID-19 data harmonization with other HIV cohorts will further aide our collective effort to understand the impact of COVID-19 on these at risk communities. Finally, C3PNO's effort to assess changes in social and individual determinants of health, vaccine attitudes, differences in substance- using behavior, and the impact HIV-affected individuals during the course of the COVID-19 pandemic is both novel and critical in this time of unprecedented social upheaval and instability.