Collaborating Consortium of Cohorts Producing NIDA Opportunities (C3PNO)

产生 NIDA 机会的群体合作联盟 (C3PNO)

• 批准号: 10352063
• 负责人: Pamina Mae Gorbach
• 金额: $ 40.09万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-05-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10352063
• 关键词: 2019-nCoV; AIDS prevention; Address; Adherence; Administrative Supplement; Affect; Appointment; Area; Attitude; Baltimore; Behavior; COVID-19; COVID-19 pandemic; COVID-19 testing; COVID-19 vaccination; California; Caring; Chicago; Collection; Communities; Competence; Consequentialism; Counseling; Data; Disease; Drug usage; Drug user; Ethnic Origin; Food; Frequencies; Funding; Funding Opportunities; HIV; HIV Infections; Health; Heart; Housing; Imprisonment; Individual; Infrastructure; Interruption; Link; Location; Los Angeles; Measures; Mediating; Medical; Medical Records; Mental Health; NIH Program Announcements; National Institute of Drug Abuse; Opioid; Outcome; Participant; Patient Self-Report; Pattern; Persons; Pharmaceutical Preparations; Population; Race; Recovery; Reporting; Research; Risk; Risk Factors; SARS-CoV-2 infection; Science; Severities; Smoking; Specific qualifier value; Structure; Substance Use Disorder; Surveys; Symptoms; Syndrome; Technology; Time; Tobacco; Universities; Vaccination; Vaccines; Vulnerable Populations; antiretroviral therapy; base; behavior test; cohort; data harmonization; design; experience; frontier; high risk; interest; intimate partner violence; marijuana vaping; novel; opioid use disorder; pandemic disease; pre-exposure prophylaxis; prescription opioid; protective behavior; public health emergency; response; social; stimulant use; substance use; substance use treatment; uptake; vaccine acceptance; vaccine hesitancy; vaping

ABSTRACT In response to the Notice of Special Interest (NOSI) regarding the Availability of Administrative Supplements and Urgent Competitive Revisions for Research on the 2019 Novel Coronavirus (Notice Number NOT-DA-20-047 and linked Program Announcement PA-18-591) funding opportunity, the Collaborating Consortium of Cohorts Producing NIDA Opportunities (C3PNO; U24DA044554) proposes to assess the impact of COVID-19 on the participating cohorts - including people who use drugs (PWUD), people living with HIV (PLWH), and those at high-risk for HIV infection. We propose to expand the C3PNO COVID-19 module developed under a previous supplement (4U24DA044554-03:S2) to include vaccination attitudes, uptake, and adherence as well as post- COVID-19 symptoms and syndrome. The new module will allow further longitudinal assessment of the practice of protective behaviors, testing, substance use, and mental health in the C3PNO cohorts for at least two more rounds six months apart resulting in two years of data related to COVID-19 pandemic experiences. This approach will allow us to longitudinally assess vaccination hesitancy/acceptability and structural factors' association with uptake and adherence to COVID-19 vaccination. Additionally, we will use our current infrastructure and C3PNO validated harmonization strategies to compile new and existing data across the cohorts in order to: assess changes in social and individual determinants of health during the course of the COVID-19 pandemic, to estimate differences in substance-using behaviors of those who were confirmed/probable cases of COVID-19 (based on self-report or medical record) and those who were not a confirmed/probable case, and to assess how PLWH and people who are at high risk for HIV in C3PNO have different experiences in and responses to the COVID-19 epidemic. The C3PNO Coordinating Center at The University of California, Los Angeles (UCLA) and Frontier Science will facilitate the design and implementation of a survey to collect data from a subset of participants from each of C3PNO cohorts (ACCESS, ALIVE, the Heart Study, HYM, JHHCC, MASH, mSTUDY, RADAR, and V- DUS). Cohorts will issue the survey to participants and transfer the resulting data to the coordinating center. If funded, this administrative supplement would allow a rapid and coordinated collection of linked COVID-19, HIV, and substance use data related to an ongoing public health emergency affecting the highly vulnerable substance- using populations followed by the cohorts. COVID-19 data harmonization with other HIV cohorts will further aide our collective effort to understand the impact of COVID-19 on these at risk communities. Finally, C3PNO's effort to assess changes in social and individual determinants of health, vaccine attitudes, differences in substance- using behavior, and the impact HIV-affected individuals during the course of the COVID-19 pandemic is both novel and critical in this time of unprecedented social upheaval and instability.

摘要 为了响应关于行政补充材料可用性的特别关注通知（NOSI）， 2019年新型冠状病毒研究的紧急竞争性修订（通知编号NOT-DA-20-047 和链接的计划公告PA-18-591）资助机会，队列合作联盟 生产NIDA机会（C3 PNO; U24 DA 044554）建议评估COVID-19对 参与队列-包括吸毒者（PWUD）、艾滋病毒感染者（PLWH）和 艾滋病毒感染的高风险。我们建议扩展C3 PNO COVID-19模块，该模块是根据先前的 补充（4U 24 DA 044554 -03：S2），包括疫苗接种态度、接种和依从性以及接种后 COVID-19症状和综合征。新模块将允许对实践进行进一步的纵向评估 保护行为，测试，物质使用和心理健康在C3 PNO队列中至少有两个以上 每隔六个月进行一次调查，得出两年的COVID-19疫情相关数据。这种方法 将使我们能够纵向评估疫苗接种犹豫/可接受性和结构因素与 接受和坚持COVID-19疫苗接种。此外，我们将使用现有的基础设施和C3 PNO 经验证的统一战略，以汇编各队列的新数据和现有数据，以便： COVID-19大流行期间社会和个人健康决定因素的变化，以估计 COVID-19确诊/可能病例的物质使用行为差异（基于 自我报告或医疗记录）和那些谁不是一个确诊/可能的情况下，并评估如何PLWH和 C3 PNO中艾滋病毒高危人群对COVID-19有不同的经历和反应 疫情位于加州大学、洛杉矶（UCLA）和Frontier的C3 PNO协调中心 科学将促进设计和实施一项调查，以收集来自以下方面的一部分参与者的数据： 每个C3 PNO队列（ACCESS、ALIVE、心脏研究、HYM、JHHCC、MASH、mSTUDY、RADAR和V- DUS）。队列将向参与者发布调查，并将结果数据传输到协调中心。如果 这项行政补充将允许快速和协调地收集相关的COVID-19，HIV， 以及与影响高度脆弱物质的持续公共卫生紧急情况有关的物质使用数据- 使用的是人群和队列。COVID-19数据与其他艾滋病毒队列的协调将进一步帮助 我们共同努力了解COVID-19对这些高危社区的影响。最后，C3 PNO的努力 评估健康的社会和个人决定因素的变化，疫苗态度，物质差异， 使用行为，以及在COVID-19大流行期间受艾滋病毒影响的个人的影响， 在这个前所未有的社会动荡和不稳定的时代，这是一个新颖和关键的问题。