SWG 1 -Translational Research on Substance Use SWG

SWG TRSU：项目摘要/摘要：物质使用 (TRSU) 战略转化研究 工作组 (SWG) 将把社区参与的专业知识与行为、基础和临床联系起来 CFAR 核心以及加州大学洛杉矶分校 (UCLA) 和基民盟 (CDU) 校园的科学家们。 TRSU 将生成 HIV 预防、治疗和非 ART 缓解交叉领域的新颖且具有高影响力的研究，以及 通过从 CFAR 活动参与者的角度检查最佳实践，物质使用/滥用 (SU) 关于 SU 数据是如何生成和使用的。 TRSU 使该领域超越了现有的测量方法 并对物质使用/滥用进行干预，以审查可接受性和实施方面的挑战 研究可用于检查影响的 SU 暴露的严格特征时的社区层面 对免疫系统和艾滋病毒储存库的影响。该 TRSU 将通过以下方式加速 OAR 优先领域的科学发展： 强调必须针对实验室和行为评估文化相关性和社区能力 对与 HIV 相关的 SU 和误用个人的药品和 SU 暴露进行评估 感染。这将使致力于了解体内艾滋病毒储存库动态的科学家能够 更好的 SU 措施，致力于提高病毒抑制率的人们将能够获得经过验证的 社区和从事艾滋病毒预防工作的人员可以接受的 SU 暴露措施将 通过药物鉴定，能够更好地识别那些可以从治疗 SU 疾病的干预措施中受益的人 使用中的产品。它还将研究如何反馈有关药品的调查结果以及当地的使用水平 从 CFAR 的实验室和科学家到研究参与者和当地护理提供者。这些 目标将通过以下方式实现： 确定可用于研究的 SU 评估创新方法 HIV 储存库和免疫重建以及流行病学、基础和临床科学研究 阻止艾滋病毒。 TRSU 将增加多学科综合评估的机会并刺激对多学科综合评估的支持 SU 和滥用，例如社区中的头发取样、通过试纸条/和/或质谱进行药品测试 通过将艾滋病毒外部的新研究人员引入这项工作来进行环境和生态瞬时评估。 TRSU 将评估社区对与研究最相关的 SU 评估方法的可接受性 艾滋病毒预防、治疗和无抗逆转录病毒治疗的缓解；并加强实验室和临床的传播 研究参与者对 SU 的评估，并为社区制定最佳实践 参与。 TRSU 将通过让社区参与指导来增强文化相关性 开发和使用可能促进物质交叉研究的研究工具 使用/误用以及 HIV 预防、治疗和无 ART 缓解这三个 CFAR 主题。

SWG TRSU: Project Summary/Abstract: The Translational Research on Substance Use (TRSU) Strategic Working Group (SWG) will connect expertise in community engagement with behavioral, basic and clinical scientists across the CFAR cores and broadly across the UCLA and CDU campuses. The TRSU will generate novel and high impact research at the intersection of HIV prevention, treatment and ART-free remission, and substance use/misuse (SU) by examining best practices from the perspective of participants in CFAR activities on how SU data is generated and used. The TRSU moves the field beyond existing approaches for measuring and intervening on substance use/misuse to examine acceptability and implementation challenges at the community level when studying rigorous characterization of SU exposure that can be used to examine impacts on the immune system, and the HIV reservoir. This TRSU will accelerate science in OAR priority areas by emphasizing that cultural relevance and community competency must be assessed for laboratory and behavioral assessments of drug products and SU exposure in individuals relevant to SU and misuse in the context of HIV infection. This will enable scientists working to understand the dynamics of the HIV reservoir in vivo to have better measures of SU, people working on improving rates of viral suppression will be able to obtain validated measures of SU exposure that are acceptable to the community, and those working on HIV prevention will be better able to identify those who can benefit from interventions to address SU disorders with identification of drug products in use. It also will examine how to feedback the findings on drug products and levels of use in local communities from laboratories and scientists in the CFAR to study participants and local care providers. These goals will be achieved by: identifying innovative methods for assessment of SU that can be used in studies of the HIV reservoir and immune reconstitution as well as in epidemiological, basic, and clinical science research to stop HIV. The TRSU will increase access to and stimulate support for multidisciplinary integrated assessments of SU and misuse such as hair sampling, drug product testing by strips/and or mass spectrometry in community settings, and ecological momentary assessments by bringing new investigators from outside HIV into this work. The TRSU will assess community acceptability of methods of assessment of SU most relevant to research on HIV prevention, treatment, and ART-free remission; and enhancing the dissemination of laboratory and clinical assessments of SU among research participants with the development of best practices for community engagement. The TRSU will enhance cultural relevance by engaging community participation in guiding development and use of research tools that can potentially advance intersectional studies of substance use/misuse and the three CFAR themes of HIV Prevention, Treatment and ART-Free Remission.