SWG 1 -Translational Research on Substance Use SWG

SWG TRSU：项目摘要/摘要：物质使用(TRSU)战略翻译研究 工作组(SWG)将把社区参与方面的专业知识与行为、基础和临床联系起来 CFAR核心以及加州大学洛杉矶分校和CDU校园的科学家们。TRSU将生成 在艾滋病毒预防、治疗和无抗逆转录病毒药物缓解的交叉点上进行的新的、高影响力的研究，以及 物质使用/滥用(SU)，从CFAR活动参与者的角度审查最佳做法 关于SU数据是如何生成和使用的。TRSU使这一领域超越了现有的测量方法 和干预物质使用/滥用，以审查可接受性和执行方面的挑战 社区层面，研究可用于检查影响的SU暴露的严格特征 对免疫系统和艾滋病毒储存库的影响。这个TRSU将通过以下方式加速桨优先领域的科学 强调必须评估实验室和行为的文化相关性和社区能力 艾滋病毒背景下与SU和滥用有关的个人中药物产品和SU暴露的评估 感染。这将使致力于了解体内艾滋病毒储存库动态的科学家能够 更好的SU措施，致力于提高病毒抑制率的人将能够获得验证 社区可以接受的SU暴露措施，以及从事艾滋病毒预防工作的人将是 能够更好地识别那些可以通过药物识别从解决SU障碍的干预中受益的人 使用中的产品。它还将研究如何反馈关于药品和当地使用水平的调查结果。 从CFAR的实验室和科学家到研究参与者和当地护理提供者的社区。这些 目标将通过以下方式实现：确定可用于研究SU的创新方法 艾滋病病毒储存库和免疫重建以及流行病学、基础和临床科学研究 来阻止艾滋病病毒。TRSU将增加对多学科综合评估的机会，并鼓励对其提供支持 SU和滥用，如头发采样、药材试条检测/和/或社区中的质谱学 通过将来自外部的新的艾滋病毒调查人员带入这项工作，进行环境和生态瞬时评估。 TRSU将评估与研究最相关的SU评估方法的社区可接受性 艾滋病毒的预防、治疗和不含抗逆转录病毒药物的缓解；以及加强实验室和临床的传播 随着社区最佳实践的发展，研究参与者对SU的评估 订婚。TRSU将通过让社区参与指导来提高文化相关性 开发和使用可能促进物质交叉研究的研究工具 使用/误用和CFAR的艾滋病毒预防、治疗和无抗逆转录病毒药物缓解三个主题。

SWG TRSU: Project Summary/Abstract: The Translational Research on Substance Use (TRSU) Strategic Working Group (SWG) will connect expertise in community engagement with behavioral, basic and clinical scientists across the CFAR cores and broadly across the UCLA and CDU campuses. The TRSU will generate novel and high impact research at the intersection of HIV prevention, treatment and ART-free remission, and substance use/misuse (SU) by examining best practices from the perspective of participants in CFAR activities on how SU data is generated and used. The TRSU moves the field beyond existing approaches for measuring and intervening on substance use/misuse to examine acceptability and implementation challenges at the community level when studying rigorous characterization of SU exposure that can be used to examine impacts on the immune system, and the HIV reservoir. This TRSU will accelerate science in OAR priority areas by emphasizing that cultural relevance and community competency must be assessed for laboratory and behavioral assessments of drug products and SU exposure in individuals relevant to SU and misuse in the context of HIV infection. This will enable scientists working to understand the dynamics of the HIV reservoir in vivo to have better measures of SU, people working on improving rates of viral suppression will be able to obtain validated measures of SU exposure that are acceptable to the community, and those working on HIV prevention will be better able to identify those who can benefit from interventions to address SU disorders with identification of drug products in use. It also will examine how to feedback the findings on drug products and levels of use in local communities from laboratories and scientists in the CFAR to study participants and local care providers. These goals will be achieved by: identifying innovative methods for assessment of SU that can be used in studies of the HIV reservoir and immune reconstitution as well as in epidemiological, basic, and clinical science research to stop HIV. The TRSU will increase access to and stimulate support for multidisciplinary integrated assessments of SU and misuse such as hair sampling, drug product testing by strips/and or mass spectrometry in community settings, and ecological momentary assessments by bringing new investigators from outside HIV into this work. The TRSU will assess community acceptability of methods of assessment of SU most relevant to research on HIV prevention, treatment, and ART-free remission; and enhancing the dissemination of laboratory and clinical assessments of SU among research participants with the development of best practices for community engagement. The TRSU will enhance cultural relevance by engaging community participation in guiding development and use of research tools that can potentially advance intersectional studies of substance use/misuse and the three CFAR themes of HIV Prevention, Treatment and ART-Free Remission.