SWG 1 -Translational Research on Substance Use SWG

SWG 1 - 物质使用转化研究 SWG

• 批准号: 10458376
• 负责人: Pamina Mae Gorbach
• 金额: $ 5.19万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-08 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10458376
• 关键词: AIDS prevention; Address; Affect; Area; Assessment tool; Back; Basic Science; Behavior assessment; Behavioral; Cannabinoids; Clinical; Clinical Informatics; Clinical Research; Clinical Sciences; Clinical assessments; Collaborations; Communities; Community Participation; Competence; Consensus; Data; Data Set; Development; Disease; Disease remission; Ecological momentary assessment; Educational workshop; Epidemiology; Exposure to; Faculty; Feedback; Goals; HIV; HIV Infections; Hair; Immune system; Individual; Infection; Intervention; Laboratories; Laboratory Research; Laboratory Scientists; Los Angeles; Mass Spectrum Analysis; Measurement; Measures; Medical; Method Acceptability; Methodology; Methods; Mission; Nail plate; Opioid; Outcome; Paper; Participant; Persons; Pharmaceutical Preparations; Pilot Projects; Prevention; Process; Research; Research Personnel; Sampling; Science; Scientist; Self Administration; Specimen; Stimulant; Translational Research; Translational Research Working Group; Viral; Voice; Work; acceptability and feasibility; analytical method; biobank; care providers; community based participatory research; community engagement; community setting; drug testing; experience; immune reconstitution; implementation barriers; improved; in vivo; innovation; meetings; member; multidisciplinary; novel; research study; substance misuse; substance use; test strip; tool; working group

SWG TRSU: Project Summary/Abstract: The Translational Research on Substance Use (TRSU) Strategic Working Group (SWG) will connect expertise in community engagement with behavioral, basic and clinical scientists across the CFAR cores and broadly across the UCLA and CDU campuses. The TRSU will generate novel and high impact research at the intersection of HIV prevention, treatment and ART-free remission, and substance use/misuse (SU) by examining best practices from the perspective of participants in CFAR activities on how SU data is generated and used. The TRSU moves the field beyond existing approaches for measuring and intervening on substance use/misuse to examine acceptability and implementation challenges at the community level when studying rigorous characterization of SU exposure that can be used to examine impacts on the immune system, and the HIV reservoir. This TRSU will accelerate science in OAR priority areas by emphasizing that cultural relevance and community competency must be assessed for laboratory and behavioral assessments of drug products and SU exposure in individuals relevant to SU and misuse in the context of HIV infection. This will enable scientists working to understand the dynamics of the HIV reservoir in vivo to have better measures of SU, people working on improving rates of viral suppression will be able to obtain validated measures of SU exposure that are acceptable to the community, and those working on HIV prevention will be better able to identify those who can benefit from interventions to address SU disorders with identification of drug products in use. It also will examine how to feedback the findings on drug products and levels of use in local communities from laboratories and scientists in the CFAR to study participants and local care providers. These goals will be achieved by: identifying innovative methods for assessment of SU that can be used in studies of the HIV reservoir and immune reconstitution as well as in epidemiological, basic, and clinical science research to stop HIV. The TRSU will increase access to and stimulate support for multidisciplinary integrated assessments of SU and misuse such as hair sampling, drug product testing by strips/and or mass spectrometry in community settings, and ecological momentary assessments by bringing new investigators from outside HIV into this work. The TRSU will assess community acceptability of methods of assessment of SU most relevant to research on HIV prevention, treatment, and ART-free remission; and enhancing the dissemination of laboratory and clinical assessments of SU among research participants with the development of best practices for community engagement. The TRSU will enhance cultural relevance by engaging community participation in guiding development and use of research tools that can potentially advance intersectional studies of substance use/misuse and the three CFAR themes of HIV Prevention, Treatment and ART-Free Remission.

SWG TRSU：项目摘要/摘要：物质使用转化研究（TRSU）战略 工作组（SWG）将把社区参与的专业知识与行为，基础和临床 科学家们在CFAR核心和广泛的加州大学洛杉矶分校和CDU校园。TRSU将生成 在艾滋病毒预防、治疗和无ART缓解的交叉领域开展新颖和高影响力的研究， 通过从CFAR活动参与者的角度审查最佳做法， 如何生成和使用SU数据。TRSU超越了现有的测量方法， 和干预药物使用/滥用问题，以审查可接受性和执行方面的挑战， 在研究可用于检查影响的SU暴露的严格特征时， 对免疫系统和艾滋病病毒库的影响。该TRSU将通过以下方式加速OAR优先领域的科学发展： 强调文化相关性和社区能力必须进行实验室和行为评估， 在HIV背景下评估与SU和误用相关的个体的制剂和SU暴露 感染这将使科学家们能够了解体内HIV库的动态， 更好的SU措施，致力于提高病毒抑制率的人们将能够获得有效的 社区可以接受的SU暴露措施，以及那些从事艾滋病毒预防工作的人， 能够更好地识别那些可以从干预措施中受益的人，以通过识别药物来解决SU疾病 使用中的产品。它还将研究如何反馈有关药物产品和当地使用水平的调查结果 从CFAR的实验室和科学家到研究参与者和当地护理提供者。这些 目标将通过以下方式实现：确定可用于以下研究的SU评估的创新方法： 艾滋病毒储存库和免疫重建以及流行病学、基础和临床科学研究 来阻止艾滋病。TRSU将增加获得多学科综合评估的机会，并鼓励支持多学科综合评估 SU和滥用，如毛发采样、通过试纸和/或质谱法进行药品检测 环境，和生态的瞬间评估，使新的调查人员从外部艾滋病毒进入这项工作。 TRSU将评估社区对SU评估方法的可接受性，这些方法与以下研究最相关： 艾滋病毒预防、治疗和无抗逆转录病毒疗法缓解;加强实验室和临床 在研究参与者中评估SU，为社区制定最佳实践 订婚TRSU将通过让社区参与指导， 开发和使用有可能推进物质交叉研究的研究工具 艾滋病毒的使用/滥用以及艾滋病毒预防、治疗和无抗逆转录病毒疗法的缓解这三个共同框架报告主题。