Insulin-regulated aminopeptidase, glucose and memory

胰岛素调节氨肽酶、葡萄糖和记忆

• 批准号: nhmrc : 509059
• 负责人: A/Pr Siew Yeen Chai
• 金额: $ 37.05万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/insulin-regulated-aminopeptidase-glucose-memory/96791
• 关键词: Insulin; regulated; aminopeptidase; glucose; memory

We have previously shown that inhibitors of IRAP improve performance in memory tasks in normal and memory impaired animals and are currently developing new treatments for memory loss using IRAP as a target. In this study, we will investigate the physiological roles of IRAP and its association with intracellular proteins. The knowledge obtained will provide insights of how the brain process memory and confirm the suitability of IRAP inhibitors as drugs for treating memory deficits.

我们之前已经证明，IRAP抑制剂可以改善正常和记忆受损动物的记忆任务表现，目前正在开发使用IRAP作为靶标的记忆丧失新疗法。在这项研究中，我们将研究IRAP的生理作用及其与细胞内蛋白质的关联。所获得的知识将提供大脑如何处理记忆的见解，并确认IRAP抑制剂作为治疗记忆缺陷的药物的适用性。