Insulin regulated aminopeptidase: a new cardiovascular target

导致心脏病发作或中风的心血管疾病是澳大利亚最大的死亡原因。我们有证据表明血管紧张素IV抑制一种新描述的酶（IRAP）在动脉粥样硬化模型中具有保护作用。令人兴奋的是，我们有初步数据表明缺乏IRAP的小鼠血管功能更好，因此我们将进一步研究这一点以及新开发的IRAP抑制剂在预防心血管疾病发展方面的有效性。

Cardiovascular disease, leading to heart attack or stroke is the largest cause of death in Australia. We have evidence that inhibition of a newly described enzyme (IRAP) by angiotensin IV is protective in a model of atherosclerosis. Excitingly we have preliminary data indicating that mice deficient in IRAP have better vascular function therefore we will further investigate this as well as the effectiveness of newly developed IRAP inhibitors in preventing development of cardiovascular disease.