Role of metallo-peptidases in the brain

金属肽酶在大脑中的作用

• 批准号: nhmrc : 1002890
• 负责人: A/Pr Siew Yeen Chai
• 金额: $ 40.11万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-metallo-peptidases-brain/108871
• 关键词: Role; metallo; peptidases; brain

Enzymes that generate or degrade peptides serve important roles - alterations in their activity can impact on a diverse range of physiological processes in healthy and diseased states. Angiotensin is a peptide that plays a critical role in regulating blood pressure and fluid balance - drugs that block the activity of its processing enzymes forms an important class of medication used to treat hypertension and heart disease. My research interest is in discovering novel roles for these enzymes.

产生或降解多肽的酶起着重要的作用--它们活性的变化可以影响健康和疾病状态下的各种生理过程。血管紧张素是一种在调节血压和液体平衡方面发挥关键作用的多肽--阻断其加工酶活性的药物构成了用于治疗高血压和心脏病的重要药物类别。我的研究兴趣是发现这些酶的新角色。