Does IRAP contribute to Alzheimer's Disease Pathology?

阿尔茨海默病是一种进行性脑部疾病，会导致记忆丧失和细胞死亡。目前所有的处方药都可以治疗记忆力丧失，但无法阻止脑细胞的恶化。我们已经开发出一类逆转记忆丧失的药物。这些药物针对的是一种名为胰岛素调节氨基肽酶(IRAP)的蛋白质。我们最近发现，这些药物还可以减轻疾病的病理。本研究旨在探讨IRAP在阿尔茨海默病病理发生和发展中的作用。

Alzheimer’s disease is a progressive brain disease which is results in memory loss and cell death. All currently prescribed drugs treat the memory loss but are unable to stop the deterioration of brain cells. We have developed a class of drugs that reverse memory loss. These drugs target a protein called insulin-regulated aminopeptidase, IRAP. We recently found that these drugs also reduce the disease pathology. This research proposal aims to investigate the role of IRAP in the initiation or progression of Alzheimer’s disease pathology.