Environmental Changes and Mosquito-Borne Diseases in Arid Environments

干旱环境中的环境变化和蚊媒疾病

• 批准号: 8516053
• 负责人: John C. Beier
• 金额: $ 52.98万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-16 至 2014-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8516053
• 关键词: Address; Affect; African; Agriculture; Animals; Anopheles Genus; Arboviruses; Area; Behavior; Birds; Case Study; Cessation of life; Clinical; Complex; Country; Culicidae; Development; Diagnostic; Disease; Disease Outbreaks; Ecology; Egypt; Entomology; Environment; Epidemic; Food; Frequencies; Geography; Goals; Habitats; Heterogeneity; Human; Infection; International; Invaded; Iraq; Irrigation; Jordan; Lead; Libya; Livestock; Malaria; Measures; Middle East; Monitor; Mosquito-borne infectious disease; Nature; Outcome; Parasitology; Plasmodium falciparum; Population; Population Dynamics; Population Growth; Process; Production; Public Health; Pump; Relative (related person); Research; Research Personnel; Research Project Grants; Resources; Rift Valley fever virus; Risk; Rivers; Rural; Saudi Arabia; Scheme; Science; Solid; Sudan; System; Technology; Universities; Vector-transmitted infectious disease; Veterinary Medicine; Water; West Nile virus; anthropogenesis; base; design; environmental change; epidemiological model; ground water; high risk; interdisciplinary approach; killings; land use; mathematical model; migration; pathogen; programs; public health relevance; response; transmission process; vector; virology

DESCRIPTION (provided by investigator): A major public health challenge is to better understand and predict how anthropogenic environmental changes affect vector-borne diseases. In response to rapidly expanding human populations many countries in the Middle East are developing unprecedented large-scale agricultural irrigation systems to increase food production. In Upper Egypt, there are major concerns that projects underway to transform desert environments for irrigated agriculture in the Old Nile Valley (about 70,000 acres) and in the Toshka Valley (nearly 1 million acres) will substantially increase the risks of important mosquito-borne diseases. These projects are creating new suitable habitats for vector populations and facilitating the migration and establishment of large human and animal populations. This project addresses the need to determine how land use and the large-scale transformation of desert environments for irrigated agriculture in Upper Egypt affects the risk and transmission dynamics of the well-established West Nile virus (WNV) and the epidemic potential of Rift Valley fever virus (RVFV) and malaria. There are 3 specific aims: 1) determine how land use and the transformation of desert environments for irrigated agriculture affect the ecology and behavior of mosquito species and their potential for pathogen transmission, 2) evaluate the extent of WNV in birds and RVFV in domestic livestock and assess how geographic heterogeneity in animal host diversity and relative abundance affects the potential for pathogen transmission, and 3) employ eco-epidemiological modeling approaches to assess the impact of environmental changes on the complex dynamics and risks of mosquito-borne diseases. This project represents a unique opportunity to prospectively quantify vector-host-pathogen population dynamics in the context of unprecedented large-scale environmental perturbations in desert environments. The outcomes of this project will contribute to integrated disease surveillance and control programs in Egypt as well as other areas of the Middle East.

描述（由研究者提供）：一个主要的公共卫生挑战是更好地了解和预测人为环境变化如何影响病媒传播的疾病。为了应对人口的迅速增长，中东许多国家正在开发前所未有的大规模农业灌溉系统，以增加粮食产量。在上埃及，人们主要担心正在进行的改造旧尼罗河谷（约7万英亩）和托什卡谷（近100万英亩）沙漠环境的灌溉农业项目将大大增加重要蚊媒疾病的风险。这些项目正在为病媒种群创造新的适宜生境，并促进大量人类和动物种群的迁徙和定居。该项目旨在确定上埃及土地利用和沙漠环境大规模改造灌溉农业如何影响西尼罗河病毒的风险和传播动态以及裂谷热病毒和疟疾的流行潜力。有三个具体目标：1）确定土地利用和沙漠环境的灌溉农业改造如何影响蚊子物种的生态和行为及其病原体传播的潜力，2）评估鸟类中的西尼罗河病毒和家畜中的RVFV的程度，并评估动物宿主多样性和相对丰度的地理异质性如何影响病原体传播的潜力，3）采用生态流行病学模拟方法评估环境变化对蚊媒疾病复杂动态和风险的影响。该项目代表了一个独特的机会，在沙漠环境中前所未有的大规模环境扰动的背景下，前瞻性地量化媒介-宿主-病原体种群动态。该项目的成果将有助于埃及以及中东其他地区的综合疾病监测和控制方案。

项目成果

A MULTI-PATCH MALARIA MODEL WITH LOGISTIC GROWTH POPULATIONS.

• DOI: 10.1137/110850761
• 发表时间: 2012-01-01
• 期刊: SIAM journal on applied mathematics
• 影响因子: 1.9
• 作者: Gao D;Ruan S
• 通讯作者: Ruan S

Modeling the distribution of the West Nile and Rift Valley Fever vector Culex pipiens in arid and semi-arid regions of the Middle East and North Africa.

• DOI: 10.1186/1756-3305-7-289
• 发表时间: 2014-06-24
• 期刊: Parasites & vectors
• 影响因子: 3.2
• 作者: Conley AK;Fuller DO;Haddad N;Hassan AN;Gad AM;Beier JC
• 通讯作者: Beier JC

Ecological niche and potential distribution of Anopheles arabiensis in Africa in 2050.

• DOI: 10.1186/1475-2875-13-213
• 发表时间: 2014-06-03
• 期刊: Malaria journal
• 影响因子: 3
• 作者: Drake JM;Beier JC
• 通讯作者: Beier JC

Geographic profiling as a novel spatial tool for targeting infectious disease control.

• DOI: 10.1186/1476-072x-10-35
• 发表时间: 2011-05-18
• 期刊: International journal of health geographics
• 影响因子: 4.9
• 作者: Le Comber SC;Rossmo DK;Hassan AN;Fuller DO;Beier JC
• 通讯作者: Beier JC

A PERIODIC ROSS-MACDONALD MODEL IN A PATCHY ENVIRONMENT.

• DOI: 10.3934/dcdsb.2014.19.3133
• 发表时间: 2014-12-01
• 期刊: Discrete and continuous dynamical systems. Series B
• 作者: Gao D;Lou Y;Ruan S
• 通讯作者: Ruan S