Parents' Translational Research Center

描述(申请人提供)：一旦青少年开始尝试酒精和其他药物；特别是当这种实验升级时，父母不准备处理如此频繁发生的严重和复杂的问题。多亏了NIDA赞助的研究，现在有了有效的、基于证据的干预措施，在这些情况下可能对父母有用--如果翻译和沟通得当的话。为了解决这一问题，我们提议成立一个家长翻译研究中心，该中心将组建一个由研究人员、沟通专家、科学顾问和家长本身组成的经验丰富的多学科团队，在不牺牲最初的护理原则或治疗方法的情况下，直接向家长适应、评估和传达这些翻译后的干预措施。这项工作根本不可能由一个研究人员或一个实验室来完成。P50机制提供了一个理想的机会，与发起精心挑选的循证干预措施的科学家一起，与翻译研究人员(来自TRI)、来自其他相关学科的研究人员(来自科学咨询委员会)、通信、营销和信息专家(来自无毒品美国伙伴关系)，以及与有经验的父母本人(来自家长咨询委员会)。该团队将整合和协同他们的个人才华，以解决该中心的组织主题：将经过验证的临床干预措施的关键要素转化为父母可以用来解决青少年药物使用问题的实用工具。拟议的中心将使用翻译知情的方法(见NIH路线图)，重点关注从采访数千名面临青少年药物滥用挑战的父母中发现的三个问题：项目1(温特斯，PI)将改编和测试以父母为中心的简短干预版本，当他们发现青少年使用活性物质时；项目2(McLellan，PI)将开发和测试青少年治疗消费者指南，该指南将提供关于社区治疗方案中可用循证做法的客观、比较信息；项目3(Kirby，Pi)将改编和测试以父母为中心的行为干预(CRECH)版本，以帮助父母参与和激励耐受治疗的青少年。

DESCRIPTION (provided by applicant): Once adolescents have begun to experiment with alcohol and other drugs; and particularly when that experimentation escalates, parents are not prepared to handle the serious and complex Issues which so regularly occur. Thanks to NIDA sponsored research, there are now potent, evidence-based Interventions that could be useful to parents in these situations - if they were translated and communicated appropriately. To address this problem we are proposing a Parents' Translational Research Center that will bring an experienced, multidisciplinary team of researchers, communications experts, scientific advisors and parents themselves to adapt, evaluate and communicate these translated interventions directly to parents - without sacrificing the original principles of care or the therapeutic approach. This work simply could not be done by a single investigator, or by a single laboratory. The P50 mechanism offers an ideal opportunity to join the scientists who originated carefully selected evidence-based interventions with translational researchers (from TRI), researchers from other relevant disciplines (from the Science Advisory Board), specialists in communications, marketing and messaging (from the Partnership for a Drug Free America); and with experienced parents themselves (from the Parent Advisory Board). This team will integrate and synergize their individual talents to address the Center's organizing theme: translating key elements of proven clinical interventions into practical tools parents can use to address the substance use problems of their adolescents. The proposed Center will use a translation-informed approach (See NIH Roadmap) to focus on three questions Identified from interviews with thousands of parents facing substance abuse challenges with their adolescents: Project 1 (Winters, PI) will adapt and test a parent-focused version of a brief intervention for parents when they discover active substance use by their adolescent; Project 2 (McLellan, PI) will develop and test a Consumer Guide to adolescent treatment that will provide objective, comparative information on evidence-based practices available in community treatment programs; Project 3 (Kirby, PI) will adapt and test a parent-focused version of a behavioral intervention (CRAFT) to help parents engage and motivate treatment-resistant adolescents.