Parents' Translational Research Center

描述（由申请人提供）：一旦青少年开始尝试酒精和其他药物；特别是当这种实验升级时，父母没有准备好处理经常发生的严重而复杂的问题。多亏了NIDA赞助的研究，现在有了强有力的、基于证据的干预措施，如果这些干预措施得到适当的翻译和沟通，可能对这些情况下的父母有用。为了解决这个问题，我们提议成立一个家长转化研究中心，由经验丰富的多学科研究人员、交流专家、科学顾问和家长自己组成的团队来适应、评估和直接向家长传达这些转化后的干预措施，同时不牺牲原有的护理原则或治疗方法。这项工作根本不可能由一个研究者或一个实验室完成。P50机制提供了一个理想的机会，让科学家们与翻译研究人员（来自TRI）、其他相关学科的研究人员（来自科学顾问委员会）、通信、营销和信息专家（来自无药物美国伙伴关系）一起，共同发起精心挑选的循证干预措施；以及有经验的家长（来自家长咨询委员会）。这个团队将整合和协同他们的个人才能来解决中心的组织主题：将经过验证的临床干预措施的关键要素转化为父母可以用来解决青少年物质使用问题的实用工具。拟议的中心将采用一种翻译知情的方法（见NIH路线图），重点关注从对数千名青少年面临药物滥用挑战的父母的采访中确定的三个问题：项目1（温特斯，PI）将适应并测试一个以父母为中心的简短干预版本，当父母发现青少年积极使用药物时；项目2 （PI McLellan）将开发和测试青少年治疗消费者指南，该指南将为社区治疗项目中可用的循证实践提供客观、比较的信息；项目3 （Kirby， PI）将调整和测试一种以家长为中心的行为干预（CRAFT），以帮助父母吸引和激励有治疗抗性的青少年。

DESCRIPTION (provided by applicant): Once adolescents have begun to experiment with alcohol and other drugs; and particularly when that experimentation escalates, parents are not prepared to handle the serious and complex Issues which so regularly occur. Thanks to NIDA sponsored research, there are now potent, evidence-based Interventions that could be useful to parents in these situations - if they were translated and communicated appropriately. To address this problem we are proposing a Parents' Translational Research Center that will bring an experienced, multidisciplinary team of researchers, communications experts, scientific advisors and parents themselves to adapt, evaluate and communicate these translated interventions directly to parents - without sacrificing the original principles of care or the therapeutic approach. This work simply could not be done by a single investigator, or by a single laboratory. The P50 mechanism offers an ideal opportunity to join the scientists who originated carefully selected evidence-based interventions with translational researchers (from TRI), researchers from other relevant disciplines (from the Science Advisory Board), specialists in communications, marketing and messaging (from the Partnership for a Drug Free America); and with experienced parents themselves (from the Parent Advisory Board). This team will integrate and synergize their individual talents to address the Center's organizing theme: translating key elements of proven clinical interventions into practical tools parents can use to address the substance use problems of their adolescents. The proposed Center will use a translation-informed approach (See NIH Roadmap) to focus on three questions Identified from interviews with thousands of parents facing substance abuse challenges with their adolescents: Project 1 (Winters, PI) will adapt and test a parent-focused version of a brief intervention for parents when they discover active substance use by their adolescent; Project 2 (McLellan, PI) will develop and test a Consumer Guide to adolescent treatment that will provide objective, comparative information on evidence-based practices available in community treatment programs; Project 3 (Kirby, PI) will adapt and test a parent-focused version of a behavioral intervention (CRAFT) to help parents engage and motivate treatment-resistant adolescents. PUBLIC HEALTH RELEVANCE: The research is relevant to NIDA's mission to bring evidence-based knowledge, interventions and tools into broad use to solve the public health issues associated with adolescent substance abuse. CENTER CHARACTERISTICS: