Clinical Evaluation Core

临床评估核心

• 批准号: 8917360
• 负责人: Maria A Oquendo
• 金额: --
• 依托单位: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-01 至 2018-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8917360
• 关键词: Autopsy; Biological; Blood; Brain; Brain imaging; Clinical; Clinical assessments; Consensus; Consultations; Data Collection; Databases; Diagnostic; Diagnostic Procedure; Drug Monitoring; Ensure; Event; Faculty; Family; Genetic; Goals; Hair; Image; Inpatients; Instruction; Intake; Interview; Laboratories; Magnetic Resonance Imaging; Maintenance; Manuscripts; Measures; Neurobiology; Outpatients; Patients; Phase; Population; Positron-Emission Tomography; Procedures; Property; Protocols documentation; Psychometrics; Recording of previous events; Recruitment Activity; Research Personnel; Risk Factors; Saliva; Social Functioning; Statistical Data Interpretation; Structure; Supervision; Time; Work; data management; experience; human subject; instrument; life history; method development; psychologic; research clinical testing; statistics; suicidal behavior; suicide victim; symposium; trait; volunteer

The Clinical Evaluation Core's (CEC) goals are: 1. Recruitment, Characterization and Retention of Human Subjects 2. Uniform Diagnostic Method and Clinical Assessment Battery Across All Projects Including Psychological Autopsies, 3. Methods Development. 4. Maintenance of Reliability among Clinical Staff. 5. Supervise Inpatient Study Phase and Conduct Outpatient Study Phase 6. Consultation to Investigators. The CEC identifies and recruits patients with MDE and post-mortem cases. Normal volunteers are recruited to provide normative values on measures used and to establish psychometric properties of measures in a nonpathological population. The CEC utilizes a core of clinical instruments covering major risk factor domains for suicidal behavior, and ensures uniformity of assessment domains and measures across the projects of the Conte Center. These assessments include Axis I and II diagnostic interviews, measures of state and trait-related risk factors, measures of suicidal behavior, demographic history, life events, social functioning, family psychiatric history. Assessments are performed at intake, at time of biological procedures, at discharge. CEC interacts extensively with other Cores and Projects in the Conte Center. The CEC conducts clinical evaluation, data collection and treatment for all Conte Center projects that include human subjects including the Clinical Project 5, PET Project 3, MRI Project 4 and Statistics Project 6. CEC works closely with the Data Management and Statistics Core (DMSC) staff to generate forms, data management procedures, and reliability statistics. CEC coordinates with the Brain Imaging Core (BIC) regarding subject recruitment, clinical interviewing, matching controls and monitoring drug washouts and subject flow through the brain imaging protocols. The CEC conducts assessments of the suicide victims whose brains are studied by the Postmortem Brain Studies Core (PMC). The CEC obtains blood, hair and saliva from subjects to be analyzed by the Neurobiology Laboratory Core (NLC). The CEC also interfaces with the Administrative Core to identify and recruit new staff and maintain a central database of CEC manuscripts. The CEC coordinates the diagnostic consensus conference for projects # 1 , 2 - 6 and maintains inter-rater reliability. CEC Faculty and staff are an experienced center structure as most have worked as a core for the past 10 years or longer.

临床评估核心(CEC)的目标是：1.招募、表征和保留人类 科目2.所有项目的统一诊断方法和临床评估组合，包括 心理尸检，3.方法发展。4.维护临床工作人员的可靠性。5. 监督住院研究阶段和进行门诊研究阶段6。咨询研究人员。这个 CEC识别和招募MDE患者和尸检病例。招募正常志愿者是为了 为所使用的测量提供标准值，并建立测量的心理测量学属性 非病态人群。CEC使用涵盖主要风险因素的核心临床仪器 自杀行为的领域，并确保整个评估领域和措施的一致性 孔蒂中心的项目。这些评估包括Axis I和II诊断性访谈、测量 与状态和特征相关的危险因素、自杀行为的测量、人口学史、生活事件、社会 功能正常，家族精神病史。评估在进食时进行，在生物时间进行 出院时的程序。CEC与Conte的其他核心和项目广泛互动 中心。CEC为所有CONTE中心项目进行临床评估、数据收集和治疗 包括人类受试者，包括临床项目5、PET项目3、MRI项目4和 统计项目6.CEC与数据管理和统计核心(DMSc)工作人员密切合作 生成表单、数据管理程序和可靠性统计数据。CEC与大脑协调 关于受试者招募、临床访谈、匹配控制和监测的成像核心(BIC) 药物洗脱和受试者通过大脑成像方案流动。CEC对 自杀受害者的大脑由死后脑研究核心(PMC)研究。CEC获得 受试者的血液、头发和唾液将由神经生物学实验室核心(NLC)分析。CEC 还与行政核心对接，以确定和征聘新工作人员，并维护中央数据库 CEC手稿。CEC协调项目#1、2-6和#3的诊断协商一致会议 维护评核人之间的可靠性。与大多数人一样，CEC的教职员工都是经验丰富的中心结构 在过去10年或更长时间内作为核心工作。