Mechanisms of Risk and Resilience in ASD: Ontogeny, Phylogeny and Gene Disruption

ASD 的风险和恢复力机制：个体发育、系统发育和基因破坏

• 批准号: 8708983
• 负责人: AMI KLIN
• 金额: $ 175.38万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-04 至 2017-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8708983
• 关键词: Address; Affect; Age-Months; Autistic Disorder; Behavioral; Birth; Caregivers; Characteristics; Child; Child Development; Childhood; Cities; Clinical; Clinical Sciences; Communities; Country; Data; Data Collection; Development; Developmental Delay Disorders; Diagnosis; Diagnostic; Elderly; Enrollment; Eye; Family; Future; Genes; Genetic; Goals; Growth; Healthcare; Healthcare Systems; Heterogeneity; Impairment; Infant; Informatics; Institution; Intervention; Laboratories; Life; Measures; Mission; Modeling; Molecular Genetics; Neurobiology; Neurosciences; Ocular Fixation; Oral cavity; Outcome; Performance; Phenotype; Phylogeny; Play; Prevalence; Primates; Procedures; Prognostic Marker; Randomized Controlled Trials; Recording of previous events; Relative (related person); Research; Resources; Risk; Risk Factors; Scanning; Science; Services; Siblings; Social Development; Speech; Staging; Techniques; Testing; Toddler; Training; Translational Research; Treatment outcome; United States National Institutes of Health; Universities; Visual; autism spectrum disorder; base; brain behavior; cohort; disability; endophenotype; expectation; high risk; improved; indexing; infancy; innovation; medical schools; meetings; nonhuman primate; novel; relating to nervous system; resilience; response; sample fixation; screening; social; social neuroscience; social skills; tool; treatment response

DESCRIPTION: The Emory ACE joins 8 laboratories in 3 institutions, creating a center for clinical and translational science built-from its outset--on the expectation of transformative impact on the community. Laboratories from the Marcus Autism Center, Emory University School of Medicine, and Yerkes National Primate Research Center combine methodological and conceptual expertise in child development, behavioral neuroscience, speech science, molecular genetics, and treatment research; all against the backdrop of a city-wide initiative for autism research driven by the largest pediatric healthcare system in the country, Children's Healthcare of Atlanta. The thematic mission of the Emory ACE guides each of its 5 projects and 4 cores: to unravel the developmental complexities of risk and resilience in autism spectrum disorders, so that we may advance the most effective and successful treatments for children. Projects I and II quantify the developmental unfolding of social visual (PI) and social vocal (Pll) engagement, from birth until 24 months of age, to identify profiles for positive outcome as well as risk factors for disability. Project III advances rigorous, randomized-control trials for treatmnt of ASD into infancy and toddlerhood, testing the extent to which developmental trajectories of social engagement (Projects I and II) predict treatment response and outcome. Also starting in infancy. Projects IV and V establish-for normative social development (PV) and a genetic means to its disruption (PIV)-a nonhuman primate model for interrogating the underpinnings of social disability in genes, brain, and behavior. Together, these Projects advance our understanding of the developmental unfolding of autism, and set the stage for changing the course of ASD prior to the point when disability is even fully manifest. Four Cores provide the resources to support these goals, spanning Assessment, Informatics, Administration and Training. In its efforts to meet and exceed the aspirational goals for autism set forth by the NIH Interagency Autism Coordinating Committee (lACC), the Emory ACE creates in its wake a new scientific community, focused on the translational social neuroscience of autism spectrum disorders, in the service of children and families.

描述：埃默里ACE加入了3个机构的8个实验室，创建了一个临床和转化科学中心——从一开始就期望对社区产生变革性影响。来自马库斯自闭症中心、埃默里大学医学院和耶基斯国家灵长类动物研究中心的实验室结合了儿童发展、行为神经科学、语言科学、分子遗传学和治疗研究方面的方法和概念专业知识；这一切都是在全国最大的儿科保健系统——亚特兰大儿童保健中心——推动的全市范围内的自闭症研究倡议的背景下进行的。埃默里ACE的主题使命指导着它的5个项目和4个核心：揭示自闭症谱系障碍的风险和恢复力的发展复杂性，以便我们可以为儿童推进最有效和最成功的治疗。项目一和项目二量化社会视觉（PI）和社会声音（Pll）的发展展开