Cycles of Social Contingency in Autism: Pivotal Transitions that Shape Infant Brain-Behavior Development in Human & Model Systems

自闭症的社会偶然性循环：塑造人类婴儿大脑行为发育的关键转变

• 批准号: 9388881
• 负责人: AMI KLIN
• 金额: $ 240.36万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-04 至 2022-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9388881
• 关键词: Accounting; Achievement; Address; Affect; Age; Age-Months; Attenuated; Autistic Disorder; Behavior; Behavioral; Biological; Biological Models; Birth; Brain; Caregivers; Characteristics; Child; Child Development; Clinical Sciences; Clinical Treatment; Clinical assessments; Communication; Communities; Community Outreach; Data; Development; Early Intervention; Early treatment; Environment; Etiology; Family; Future; Genes; Genetic Predisposition to Disease; Genetic Risk; Goals; Growth; Healthcare Systems; Human; Individual; Individual Differences; Infant; Informatics; Institution; Intellectual functioning disability; Intervention; Laboratories; Language; Learning; Letters; Life; Macaca mulatta; Mainstreaming; Measures; Mediator of activation protein; Methodology; Methods; Mission; Modality; Modeling; Monkeys; National Institute of Mental Health; Neurobiology; Neurosciences; Outcome; Postdoctoral Fellow; Randomized Controlled Trials; Research; Research Priority; Resources; Sampling; Science; Scientist; Series; Services; Shapes; Signal Detection Analysis; Social Development; Social Interaction; Speech; Structure; Sum; Symptoms; System; Techniques; Technology; Testing; Toddler; Translational Research; Treatment outcome; Universities; Visual; Work; autism spectrum disorder; base; behavioral study; brain behavior; clinical care; cohort; disability; evidence base; expectation; functional outcomes; health care delivery; high risk; implementation science; infancy; innovation; next generation; nonhuman primate; outreach; predictive of treatment response; programs; prospective; response; social; social communication; social engagement; social neuroscience; symptomatology; tool; treatment effect; treatment strategy

PROJECT SUMMARY The Emory ACE joins 12 laboratories in 6 institutions under the auspices of Emory University, creating a center for clinical and translational science built – from its outset – on the expectation of transformative impact on the community. These laboratories combine methodological and conceptual expertise in child development, speech science, behavioral neuroscience, and treatment research. The thematic mission of the Emory ACE guides each of its 5 projects and 4 cores: to execute science that leads directly to a future of optimized outcomes for the next generations of children with autism spectrum disorder (ASD). Projects I-III study reciprocal behavior, in the visual and vocal, brain and behavior domains, within the first six months of life, and in subsequent brain-behavior transitions until 30 months of age, in infants and toddlers at low and high risk for ASD. Project IV advances rigorous, randomized-controlled trials for treatment of ASD into infancy and toddlerhood, testing infant and infant- caregiver characteristics that predict treatment response and outcome; its goal is to optimize treatment effects, personalized to the developmental stage of the child, and within the structure of the child-caregiver dyad. Project V advances a nonhuman primate model of social development, interrogating the underpinnings of social disability in brain and behavior studies. Together, these Projects advance our understanding of the developmental unfolding of ASD, and sets the stage for changing its course prior to the point when disability is even fully manifest. Four Cores provide the resources to support these goals, spanning Clinical Assessment and Care, Informatics, Administration and Dissemination & Outreach. In its efforts to meet and exceed the aspirational goals for autism set forth by the US DHSS Interagency Autism Coordinating Committee and by NIMH Research Priorities, the Emory ACE expands a new scientific community, focused on the translational social neuroscience of ASD, in service of children and families. Its ultimate goal is to change the narrative of ASD from one of potentially devastating disability to one of positive diversity, in which individuals with autism are able to succeed despite their learning differences and because of their unique assets, unencumbered by the burdens of language, intellectual disabilities, and severe behavior challenges.

项目概要 Emory ACE 联合埃默里大学旗下 6 个机构的 12 个实验室，创建了一个中心 临床和转化科学从一开始就建立在对变革性影响的期望之上 社区。这些实验室结合了儿童发展、言语方面的方法和概念专业知识 科学、行为神经科学和治疗研究。埃默里 ACE 的主题使命指导着每个人 其 5 个项目和 4 个核心：执行科学，直接引领未来优化结果的未来 几代患有自闭症谱系障碍（ASD）的儿童。项目 I-III 研究视觉上的交互行为 以及声音、大脑和行为领域，在生命的前六个月内以及随后的大脑行为中 自闭症谱系障碍 (ASD) 低风险和高风险婴儿和幼儿的过渡期直至 30 个月大。项目IV取得进展 针对婴儿期和幼儿期自闭症谱系障碍（ASD）治疗的严格随机对照试验，测试婴儿和婴幼儿 预测治疗反应和结果的护理人员特征；其目标是优化治疗效果， 根据儿童的发展阶段以及儿童-看护者二人组的结构进行个性化。项目 V 提出了一种非人类灵长类动物的社会发展模型，质疑社会残疾的基础 在大脑和行为研究中。这些项目共同推进了我们对发展的理解 自闭症谱系障碍（ASD）的展开，并为在残疾完全显现之前改变其进程奠定了基础。 四个核心提供资源来支持这些目标，涵盖临床评估和护理、信息学、 管理、传播和外展。努力实现并超越自闭症的理想目标 由美国 DHSS 机构间自闭症协调委员会和 NIMH 研究优先事项制定， Emory ACE 扩大了一个新的科学界，专注于 ASD 的转化社会神经科学， 儿童和家庭服务。其最终目标是改变自闭症谱系障碍的叙述，从潜在的一种 毁灭性的残疾对积极多样性之一来说是一种毁灭性的残疾，在这种多样性中，自闭症患者尽管 他们的学习差异以及由于他们独特的资产而不受语言负担的阻碍， 智力障碍和严重的行为挑战。