Cycles of Social Contingency in Autism: Pivotal Transitions that Shape Infant Brain-Behavior Development in Human & Model Systems

自闭症的社会偶然性循环：塑造人类婴儿大脑行为发育的关键转变

• 批准号: 9388881
• 负责人: AMI KLIN
• 金额: $ 240.36万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-04 至 2022-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9388881
• 关键词: Accounting; Achievement; Address; Affect; Age; Age-Months; Attenuated; Autistic Disorder; Behavior; Behavioral; Biological; Biological Models; Birth; Brain; Caregivers; Characteristics; Child; Child Development; Clinical Sciences; Clinical Treatment; Clinical assessments; Communication; Communities; Community Outreach; Data; Development; Early Intervention; Early treatment; Environment; Etiology; Family; Future; Genes; Genetic Predisposition to Disease; Genetic Risk; Goals; Growth; Healthcare Systems; Human; Individual; Individual Differences; Infant; Informatics; Institution; Intellectual functioning disability; Intervention; Laboratories; Language; Learning; Letters; Life; Macaca mulatta; Mainstreaming; Measures; Mediator of activation protein; Methodology; Methods; Mission; Modality; Modeling; Monkeys; National Institute of Mental Health; Neurobiology; Neurosciences; Outcome; Postdoctoral Fellow; Randomized Controlled Trials; Research; Research Priority; Resources; Sampling; Science; Scientist; Series; Services; Shapes; Signal Detection Analysis; Social Development; Social Interaction; Speech; Structure; Sum; Symptoms; System; Techniques; Technology; Testing; Toddler; Translational Research; Treatment outcome; Universities; Visual; Work; autism spectrum disorder; base; behavioral study; brain behavior; clinical care; cohort; disability; evidence base; expectation; functional outcomes; health care delivery; high risk; implementation science; infancy; innovation; next generation; nonhuman primate; outreach; predictive of treatment response; programs; prospective; response; social; social communication; social engagement; social neuroscience; symptomatology; tool; treatment effect; treatment strategy

PROJECT SUMMARY The Emory ACE joins 12 laboratories in 6 institutions under the auspices of Emory University, creating a center for clinical and translational science built – from its outset – on the expectation of transformative impact on the community. These laboratories combine methodological and conceptual expertise in child development, speech science, behavioral neuroscience, and treatment research. The thematic mission of the Emory ACE guides each of its 5 projects and 4 cores: to execute science that leads directly to a future of optimized outcomes for the next generations of children with autism spectrum disorder (ASD). Projects I-III study reciprocal behavior, in the visual and vocal, brain and behavior domains, within the first six months of life, and in subsequent brain-behavior transitions until 30 months of age, in infants and toddlers at low and high risk for ASD. Project IV advances rigorous, randomized-controlled trials for treatment of ASD into infancy and toddlerhood, testing infant and infant- caregiver characteristics that predict treatment response and outcome; its goal is to optimize treatment effects, personalized to the developmental stage of the child, and within the structure of the child-caregiver dyad. Project V advances a nonhuman primate model of social development, interrogating the underpinnings of social disability in brain and behavior studies. Together, these Projects advance our understanding of the developmental unfolding of ASD, and sets the stage for changing its course prior to the point when disability is even fully manifest. Four Cores provide the resources to support these goals, spanning Clinical Assessment and Care, Informatics, Administration and Dissemination & Outreach. In its efforts to meet and exceed the aspirational goals for autism set forth by the US DHSS Interagency Autism Coordinating Committee and by NIMH Research Priorities, the Emory ACE expands a new scientific community, focused on the translational social neuroscience of ASD, in service of children and families. Its ultimate goal is to change the narrative of ASD from one of potentially devastating disability to one of positive diversity, in which individuals with autism are able to succeed despite their learning differences and because of their unique assets, unencumbered by the burdens of language, intellectual disabilities, and severe behavior challenges.

项目总结 埃默里ACE加入了埃默里大学赞助的6个机构的12个实验室，创建了一个中心 对于临床和转化科学-从一开始就建立在对 社区。这些实验室结合了儿童发展方面的方法学和概念性专业知识， 科学、行为神经科学和治疗研究。Emory ACE的主题使命指导着每个人 在其5个项目和4个核心中：执行直接导致下一步优化结果的未来的科学 一代代患有自闭症谱系障碍(ASD)的儿童。项目I-III研究视觉中的互惠行为 以及发声、大脑和行为领域，在生命的前六个月和随后的大脑行为中 过渡到30个月大的婴儿和蹒跚学步的儿童，ASD的低风险和高风险。项目四取得进展 治疗婴幼儿和蹒跚学步的ASD的严格的随机对照试验，测试婴儿和婴儿- 预测治疗反应和结果的照顾者特征；其目标是优化治疗效果， 根据儿童的发展阶段进行个性化，并在儿童-照顾者二元结构内进行。项目 V提出了一个非人类的灵长类社会发展模型，质疑了社会残疾的基础 在大脑和行为研究方面。总之，这些项目促进了我们对发展的理解 自闭症的展开，并为在残疾甚至完全显现之前改变其路线奠定了基础。 四个核心提供支持这些目标的资源，涵盖临床评估和护理、信息学、 管理和传播&外展。在努力达到和超过自闭症的理想目标方面 由美国DHSS机构间自闭症协调委员会和NIMH研究优先项目提出， Emory ACE扩展了一个新的科学社区，专注于ASD的翻译社会神经科学，在 儿童和家庭服务。它的最终目标是改变对ASD的叙述，从潜在的 毁灭性的残疾转变为积极的多样性，在这种情况下，自闭症患者能够成功，尽管 他们的学习差异，因为他们独特的资产，不受语言负担的拖累， 智力残疾和严重的行为挑战。