Mechanisms of Risk and Resilience in ASD: Ontogeny, Phylogeny and Gene Disruption

ASD 的风险和恢复力机制：个体发育、系统发育和基因破坏

• 批准号: 8893147
• 负责人: AMI KLIN
• 金额: $ 161.12万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-04 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8893147
• 关键词: Address; Affect; Age-Months; Autistic Disorder; Behavioral; Birth; Caregivers; Characteristics; Child; Child Development; Childhood; Cities; Clinical; Clinical Sciences; Communities; Country; Data; Data Collection; Development; Developmental Delay Disorders; Diagnosis; Diagnostic; Elderly; Enrollment; Eye; Family; Future; Genes; Genetic; Goals; Growth; Healthcare; Healthcare Systems; Heterogeneity; Impairment; Infant; Informatics; Institution; Intervention; Laboratories; Life; Measures; Mission; Modeling; Molecular Genetics; Neurobiology; Neurosciences; Ocular Fixation; Oral cavity; Outcome; Performance; Phenotype; Phylogeny; Play; Prevalence; Primates; Procedures; Prognostic Marker; Randomized Controlled Trials; Recording of previous events; Relative (related person); Research; Resources; Risk; Risk Factors; Scanning; Science; Services; Siblings; Social Development; Speech; Staging; Techniques; Testing; Toddler; Training; Translational Research; Treatment outcome; United States National Institutes of Health; Universities; Visual; autism spectrum disorder; base; brain behavior; cohort; disability; endophenotype; expectation; high risk; improved; indexing; infancy; innovation; medical schools; meetings; nonhuman primate; novel; relating to nervous system; resilience; response; sample fixation; screening; social; social neuroscience; social skills; tool; treatment response

DESCRIPTION: The Emory ACE joins 8 laboratories in 3 institutions, creating a center for clinical and translational science built-from its outset--on the expectation of transformative impact on the community. Laboratories from the Marcus Autism Center, Emory University School of Medicine, and Yerkes National Primate Research Center combine methodological and conceptual expertise in child development, behavioral neuroscience, speech science, molecular genetics, and treatment research; all against the backdrop of a city-wide initiative for autism research driven by the largest pediatric healthcare system in the country, Children's Healthcare of Atlanta. The thematic mission of the Emory ACE guides each of its 5 projects and 4 cores: to unravel the developmental complexities of risk and resilience in autism spectrum disorders, so that we may advance the most effective and successful treatments for children. Projects I and II quantify the developmental unfolding of social visual (PI) and social vocal (Pll) engagement, from birth until 24 months of age, to identify profiles for positive outcome as well as risk factors for disability. Project III advances rigorous, randomized-control trials for treatmnt of ASD into infancy and toddlerhood, testing the extent to which developmental trajectories of social engagement (Projects I and II) predict treatment response and outcome. Also starting in infancy. Projects IV and V establish-for normative social development (PV) and a genetic means to its disruption (PIV)-a nonhuman primate model for interrogating the underpinnings of social disability in genes, brain, and behavior. Together, these Projects advance our understanding of the developmental unfolding of autism, and set the stage for changing the course of ASD prior to the point when disability is even fully manifest. Four Cores provide the resources to support these goals, spanning Assessment, Informatics, Administration and Training. In its efforts to meet and exceed the aspirational goals for autism set forth by the NIH Interagency Autism Coordinating Committee (lACC), the Emory ACE creates in its wake a new scientific community, focused on the translational social neuroscience of autism spectrum disorders, in the service of children and families.

描述：Emory Ace加入了3个机构的8个实验室，创建了从一开始就建立临床和转化科学的中心，这是对社区的变革性影响的期望。来自Marcus自闭症中心，埃默里大学医学院和Yerkes国家灵长类动物研究中心的实验室结合了儿童发展，行为神经科学，言语科学，分子遗传学和治疗研究方面的方法论和概念专业知识；全部是在全市自闭症研究计划的背景下，该计划是由该国最大的儿科医疗体系（亚特兰大儿童医疗保健）驱动的。 Emory Ace的主题使命指导其5个项目和4个核心：揭示自闭症谱系障碍风险和韧性的发展复杂性，以便我们可以推动对儿童的最有效和最成功的治疗方法。项目I和II量化了社会视觉（PI）和社会声乐（PLL）的发展发展 从出生到24个月大的参与，以确定阳性结果以及残疾风险因素的概况。项目III正在进行严格的，随机控制的试验，以治疗ASD的婴儿期和幼儿期，以测试社会参与的发展轨迹的程度（I和II项目I和II）预测治疗反应和结果。也从婴儿期开始。项目IV和V建立了规范性社会发展（PV）及其破坏的遗传手段（PIV） - 一种非人类灵长类动物模型，用于询问基因，大脑和行为中社会残疾的基础。这些项目共同提高了我们对自闭症发展发展的理解，并为在残疾完全体现的时候改变ASD的过程奠定了基础。四个核心提供了支持这些目标，跨越评估，信息学，管理和培训的资源。在努力实现并超越了NIH机构间自闭症协调委员会（LACC）提出的自闭症的理想目标时，Emory Ace在其尾声中创造了一个新的科学界，侧重于自闭症谱系障碍的转化社会神经科学，在儿童和家庭中为儿童服务。