Maternal comorbidities, prescription drug use in pregnancy and childhood cancer

孕产妇合并症、妊娠期处方药使用和儿童癌症

基本信息

批准号：
8691193
负责人：
Julia Heck
金额：
$ 18.1万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-04-14 至 2016-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8691193
关键词：
Acute Adult Antibiotics Anticonvulsants Antidepressive Agents Arthritis Cancer Etiology Carcinogens Case-Control Studies Cause of Death Chemical Exposure Chemicals Child Child health care Chronic Collaborations Comorbidity Data Data Linkages Databases Denmark Development Diabetes Mellitus Diagnosis Diagnostic Diethylstilbestrol Disease Diuretics Dose Drops Drug Prescriptions Drug usage Eclampsia Environment Epidemiology Epilepsy Goals Health Healthcare Hormones Hypertension Intake International Classification of Disease Codes International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10)Link Literature Malignant Childhood Neoplasm Malignant Neoplasms Maternal Health Medical Records Methods Migraine Monitor Mothers Nausea Occupational Oral Contraceptives Outcome Participant Patients Perinatal Pharmaceutical Preparations Pharmacologic Substance Population Pre-Eclampsia Pregnancy Prevalence Recommendation Records Registries Research Design Resources Risk Safety Sampling Selection Bias Septic Toxemia Source Therapeutic Woman anticancer research cancer risk carcinogenicity case control design early childhood experience fetal drug exposure interest neoplasm registry offspring population based pregnant prenatal prospective public health relevance screening unborn child

项目摘要

DESCRIPTION (provided by applicant): In recent years there has been a growing recognition of the importance of maternal health and the uterine environment in the later health of children. Many women experience chronic or acute health conditions while pregnant, and a few studies have linked certain conditions with increased pediatric cancer risk. Maternal health care may further involve the use of medications to treat a preexisting condition or a condition that develops during the prenatal period. It is well-established that maternal intake of diethylstilbestrol (DES) causes cancer in offspring, however for most drugs, the evidence on safety in pregnancy is limited. The aim of this study is to examine common maternal health conditions and prescription drug use in pregnancy in relation to later childhood cancer development. Specific aims: (1) Create a linked database of all childhood cancers in Denmark (1977-2012) with information on maternal comorbidities and medication use. (2) Examine the relation between maternal comorbid conditions and childhood cancers. (3) Examine the relation between maternal prescription drug use in pregnancy and childhood cancers. Design and methods: A national case-control study using national registries in Denmark, using data from an existing study on childhood cancers in Denmark (n=537,000). Maternal comorbidity information will be available from the Danish National Patient Register (1977-2012), and prescription drug use in pregnancy from the Danish National Prescription Register (1994-2012). Data on demographic, gestational, and other factors will be available from other national registers. Implications: the findings will add evidence on childhood cancer risk among children of mothers with certain health conditions or who took specific medications during pregnancy. The results will indicate if more active monitoring and screening is needed to reduce the potentially increased risk for the unborn child, and can help guide recommendations on medication use in pregnancy.

描述（由申请人提供）：近年来，人们对孕产妇健康和子宫环境在后来的儿童健康中的重要性越来越多。许多妇女在怀孕期间经历了慢性或急性健康状况，一些研究将某些疾病与儿科癌症风险增加联系起来。孕产妇的医疗保健可能进一步涉及使用药物治疗先前存在的疾病或在产前期间发展的疾病。尚有公认的是，母体的二乙基stilbestrol（DES）在后代引起癌症，但是对于大多数药物而言，关于妊娠安全性的证据是有限的。这项研究的目的是检查与后来儿童癌症发展有关的常见孕妇健康状况和处方药的使用。具体目的：（1）在丹麦（1977-2012）中创建一个链接的数据库，并提供有关孕产妇合并症和药物使用的信息。（2）检查孕产妇合并状况与儿童癌症之间的关系。（3）检查孕妇处方药在怀孕和儿童期癌症中的关系。设计和方法：一项国家案件对照研究，使用丹麦的国家注册表，使用丹麦现有童年癌症研究的数据（n = 537,000）。孕产妇合并症信息将从丹麦国家患者登记册（1977-2012）中获得，并在丹麦国家处方注册（1994-2012）怀孕中使用处方药。其他国家记录将获得有关人口，妊娠和其他因素的数据。含义：这些发现将增加有关患有某些健康状况或怀孕期间服用特定药物的母亲儿童的儿童癌症风险的证据。结果将指示是否需要更积极的监测和筛查，以减少未出生儿童的潜在风险，并可以帮助指导怀孕中有关药物使用的建议。