Maternal comorbidities, prescription drug use in pregnancy and childhood cancer

孕产妇合并症、妊娠期处方药使用和儿童癌症

• 批准号: 8838060
• 负责人: Julia Heck
• 金额: $ 14.16万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-14 至 2017-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8838060
• 关键词: Acute; Adult; Antibiotics; Anticonvulsants; Antidepressive Agents; Arthritis; Cancer Etiology; Carcinogens; Case-Control Studies; Cause of Death; Chemical Exposure; Chemicals; Child; Child health care; Chronic; Collaborations; Comorbidity; Data; Data Linkages; Databases; Denmark; Development; Diabetes Mellitus; Diagnosis; Diagnostic; Diethylstilbestrol; Disease; Diuretics; Dose; Drops; Drug Prescriptions; Drug usage; Eclampsia; Environment; Epidemiology; Epilepsy; Goals; Health; Healthcare; Hormones; Hypertension; Intake; International Classification of Disease Codes; International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10); Link; Literature; Malignant Childhood Neoplasm; Malignant Neoplasms; Maternal Health; Medical Records; Methods; Migraine; Monitor; Mothers; Nausea; Occupational; Oral Contraceptives; Outcome; Participant; Patients; Perinatal; Pharmaceutical Preparations; Pharmacologic Substance; Population; Pre-Eclampsia; Pregnancy; Prevalence; Recommendation; Records; Registries; Research Design; Resources; Risk; Safety; Sampling; Selection Bias; Septic Toxemia; Source; Therapeutic; Woman; anticancer research; cancer risk; carcinogenicity; case control; design; early childhood; experience; fetal drug exposure; interest; neoplasm registry; offspring; population based; pregnant; prenatal; prospective; screening; unborn child

DESCRIPTION (provided by applicant): In recent years there has been a growing recognition of the importance of maternal health and the uterine environment in the later health of children. Many women experience chronic or acute health conditions while pregnant, and a few studies have linked certain conditions with increased pediatric cancer risk. Maternal health care may further involve the use of medications to treat a preexisting condition or a condition that develops during the prenatal period. It is well-established that maternal intake of diethylstilbestrol (DES) causes cancer in offspring, however for most drugs, the evidence on safety in pregnancy is limited. The aim of this study is to examine common maternal health conditions and prescription drug use in pregnancy in relation to later childhood cancer development. Specific aims: (1) Create a linked database of all childhood cancers in Denmark (1977-2012) with information on maternal comorbidities and medication use. (2) Examine the relation between maternal comorbid conditions and childhood cancers. (3) Examine the relation between maternal prescription drug use in pregnancy and childhood cancers. Design and methods: A national case-control study using national registries in Denmark, using data from an existing study on childhood cancers in Denmark (n=537,000). Maternal comorbidity information will be available from the Danish National Patient Register (1977-2012), and prescription drug use in pregnancy from the Danish National Prescription Register (1994-2012). Data on demographic, gestational, and other factors will be available from other national registers. Implications: the findings will add evidence on childhood cancer risk among children of mothers with certain health conditions or who took specific medications during pregnancy. The results will indicate if more active monitoring and screening is needed to reduce the potentially increased risk for the unborn child, and can help guide recommendations on medication use in pregnancy.

描述（由申请人提供）：近年来，人们越来越认识到孕产妇健康和子宫环境对儿童后期健康的重要性。许多妇女在怀孕期间经历慢性或急性健康状况，一些研究将某些疾病与儿童癌症风险增加联系起来。产妇保健还可能涉及使用药物治疗先前存在的病症或产前期间出现的病症。已证实母体摄入己烯雌酚（DES）会导致后代患癌症，但对于大多数药物，妊娠期安全性的证据有限。这项研究的目的是检查常见的孕产妇健康状况和处方药的使用在怀孕后期儿童癌症的发展。具体目标：（1）建立一个丹麦所有儿童癌症的链接数据库（1977-2012年），提供关于孕产妇合并症和药物使用的信息。(2)检查母亲共病状况和儿童癌症之间的关系。(3)检查母亲在怀孕期间使用处方药与儿童癌症之间的关系。设计和方法：一项使用丹麦国家登记的国家病例对照研究，使用了丹麦儿童癌症现有研究的数据（n= 537，000）。孕产妇合并症信息将从丹麦国家患者登记册（1977-2012）中获得，妊娠期处方药使用情况将从丹麦国家处方登记册（1994-2012）中获得。人口统计学、妊娠和其他因素的数据可从其他国家登记册获得。含义：研究结果将为患有某些健康状况或在怀孕期间服用特定药物的母亲的儿童癌症风险提供更多证据。研究结果将表明是否需要更积极的监测和筛查来降低未出生婴儿的潜在风险，并有助于指导怀孕期间药物使用的建议。

项目成果

Maternal autoimmune disease and its association with childhood cancer: A population-based case-control study in Denmark.

母亲自身免疫性疾病及其与儿童癌症的关联：丹麦的一项基于人群的病例对照研究。

• DOI: 10.1016/j.ejcped.2024.100145
• 发表时间: 2024
• 期刊: EJC paediatric oncology
• 作者: Orimoloye,HelenT;Nguyen,Nicholas;Deng,Chuanjie;Saechao,Chai;Ritz,Beate;Olsen,Jorn;Hansen,Johnni;Heck,JuliaE
• 通讯作者: Heck,JuliaE

Passive exposure to agricultural pesticides and risk of childhood leukemia in an Italian community.

• DOI: 10.1016/j.ijheh.2016.09.015
• 发表时间: 2016-11
• 期刊: INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
• 影响因子: 6
• 作者: Malagoli, Carlotta;Costanzini, Sofia;Heck, Julia E.;Malavolti, Marcella;De Girolamo, Gianfranco;Oleari, Paola;Palazzi, Giovanni;Teggi, Sergio;Vinceti, Marco
• 通讯作者: Vinceti, Marco

Hyperemesis gravidarum and the risk of childhood cancer - A case-control study in Denmark.

• DOI: 10.1016/j.canep.2023.102472
• 发表时间: 2023-12
• 期刊: CANCER EPIDEMIOLOGY
• 影响因子: 2.6
• 作者: Orimoloye, Helen T.;Deng, Chuanjie;Hansen, Johnni;Olsen, Jorn;Saechao, Chai;Ritz, Beate;Heck, Julia E.
• 通讯作者: Heck, Julia E.

Preeclampsia, antihypertensive medication use in pregnancy and risk of childhood cancer in offspring.

• DOI: 10.1007/s10552-023-01745-4
• 发表时间: 2024-01
• 期刊: CANCER CAUSES & CONTROL
• 影响因子: 2.3
• 作者: Askins, Lexie;Orimoloye, Helen T.;Deng, Chuanjie;Hansen, Johnni;Olsen, Jorn;Ritz, Beate;Janzen, Carla;Heck, Julia E.
• 通讯作者: Heck, Julia E.

Maternal migraine and risk of pediatric cancers.

• DOI: 10.1002/pbc.30385
• 发表时间: 2023-07
• 期刊: Pediatric blood & cancer
• 影响因子: 3.2