Childhood Cancer and Industrial Pollution (CHIP)

项目总结 癌症是儿童疾病死亡的主要原因，预计儿童癌症人数为11060人 2019年的案件。儿科癌症的影响超过了早期生命，幸存者已经减少。 与普通人群相比，健康状况和慢性健康问题的风险更大。在成年人中， 很明显，职业性接触非常高水平的特定制剂会增加癌症的发生。 风险。公众强烈怀疑环境毒素是导致儿童癌症的原因之一， 重要的是，对儿童癌症的环境决定因素进行系统调查，以 支持或驳斥这些联系。该项目是一项以人群为基础的病例对照研究。 孕期和儿童早期的工业污染与儿童癌症发展的关系。我们建议 从美国国立卫生研究院资助的两项研究(空气污染与儿童癌症研究和农药研究)中提取案例 接触和儿童癌症研究)，并检查居民区是否接近工业污染源； 我们之前已经为我们样本的一部分重建了完整的居住历史。对照组被选择 从加州出生记录中随机抽取(N=29,445例特定儿童癌症类型，983,440例 控制)。暴露测量将从环境保护局的有毒物质释放中进行 库存(TRI)。拟议研究中主要利益的暴露包括疑似和已确定的 致癌物质是加州工业释放的最常见的有毒物质之一。我们会 国际癌症研究机构对致癌物质进行特别关注的审查 癌症。这项研究丰富了关于其他环境暴露和潜在混杂因素的现有数据，在 除了使用地理信息系统开发详细的暴露指标外，还将使调查人员能够 对儿科环境病因知识现状的可操作贡献 癌症。

Project summary Cancer is the leading cause of death by disease among children, with an expected 11,060 childhood cancer cases in 2019. The effects of pediatric cancers extend beyond early life, with survivors having diminished health status and a greater risk for chronic health problems in comparison to the general population. In adults, it is clearly established that occupational exposure to very high levels of specific agents has increased cancer risks. Environmental toxins are strongly suspected by the public to contribute etiologically to pediatric cancers, and it is important that the environmental determinants of pediatric cancers are systematically investigated to support or refute these links. The proposed project is a population-based case-control study of exposure to industrial pollution in pregnancy and early childhood in relation to childhood cancer development. We propose to take cases from two NIH-funded studies (the Air Pollution and Childhood Cancers study and the Pesticide Exposure and Childhood Cancers study) and examine residential proximity to sources of industrial pollution; we have previously reconstructed full residential histories for a portion of our sample. Controls were selected at random from California birth records (N=29,445 cases of specified childhood cancer types, 983,440 controls). Exposure measurements will be taken from the Environmental Protection Agency's Toxics Release Inventory (TRI). The exposures of primary interest in the proposed study include suspected and established carcinogens which are amongst the most commonly released toxic agents by industries in California. We will focus on agents of particular interest for carcinogenic review by the International Agency for Research on Cancer. The study's wealth of existing data on other environmental exposures and potential confounders, in addition to the use of GIS for development of detailed exposure metrics, will enable the investigators to make an actionable contribution to the current state of knowledge regarding environmental causes of pediatric cancers.