Gene Expression

项目总结（见说明）： 基因表达和调控计划（格尔）由八个实验室组成，在基因转录和染色质生物学领域合作。该计划的总体目标是揭示基因表达失调如何驱动恶性转化和疾病进展，并为癌症治疗提供新的，易处理的靶点。该计划汇集了围绕三个一般旗舰主题的卓越研究的互补专业知识：转录调控，表观遗传学和染色体组织（i）。结构分析和化学生物学（ii）;和RNA介导的基因调控和microRNA代谢（iii）。在上一个预算周期，格尔研究人员在推进他们的科学追求方面取得了令人印象深刻的成就。这反映在顶级文献中发表了157篇癌症相关同行评审文章，计划内和计划间合作出版物的数量从2008年的10%增加到2012年的23%，以及国家癌症研究所（NCI）计划资金从2008年的85万美元增加到2012年的180万美元。加上其他与癌症相关的同行评审奖项共计200万美元，以及非同行评审的130万美元支持，格尔计划的总资金基础现在为29个个人奖项和520万美元（直接成本）。总体而言，该计划继续作为跨学科合作，研究生教育和癌症中心以及邻近学术机构内的跨学科互动的中心。格尔计划是两个T32培训赠款的所在地，也是三个合作P01赠款的关键贡献者，它切实推进了癌症中心的长期目标，将癌症基因表达的基本理解与转移、染色体不稳定性和发育治疗的机制途径联系起来。

PROJECT SUMMARY (See instructions): The Gene Expression and Regulation Program (GER) is comprised of eight laboratories that work together in the areas of gene transcription and chromatin biology. The overarching goals of the Program are to unravel how deregulated gene expression drives malignant transformation and disease progression, and to provide novel, tractable targets for cancer therapy. The Program brings together complementary expertise of research excellence around three general flagship themes: Transcriptional regulation, epigenetics, and chromosome organization (i). Structural analysis and chemical biology (ii); and RNA-mediated gene regulation and microRNA metabolism (iii). Over the last budget cycle, GER investigators have made impressive gains in advancing their scientific pursuits. This is reflected in the publication of 157 cancer related peer-reviewed articles in the top-tier literature, an increase in the number of intra- and interprogrammatic collaborative publications from 10% in 2008 to 23% in 2012, and a doubling of National Cancer Institute (NCI) programmatic funding from $0.85 million in 2008 to $1.8 million in 2012. Together with other cancer-related peer-reviewed awards totaling $2 million, and non-peer-reviewed support of $1.3 million, the total funding base of the GER Program now stands at 29 individual awards and $5.2 million (direct costs). Overall, the Program has continued to function as a hub for transdisciplinary collaboration, graduate education, and inter-programmatic interaction within the Cancer Center, as well as neighboring academic Institutions. The home of two T32 training grants and a pivotal contributor to three collaborative P01 grants, the GER Program has tangibly advanced the long-term goals of the Cancer Center connecting basic understanding of cancer gene expression to mechanistic pathways of metastasis, chromosomal instability and developmental therapeutics.