Molecular and Cellular Oncogenesis

分子和细胞肿瘤发生

• 批准号: 8690263
• 负责人: Dario C Altieri
• 金额: $ 3.77万
• 依托单位: WISTAR INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-03-01 至 2019-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8690263
• 关键词: Area; Basic Cancer Research; Biological Markers; Biology; Budgets; Cancer Biology; Cancer Center; Cancer Center Support Grant; Cancer Research Project; Collaborations; Direct Costs; Disease; Disease Resistance; Education; Faculty; Foundations; Funding; Gene Expression Regulation; Goals; Growth; Instruction; Interest Group; Investigation; Lead; Left; Maintenance; Malignant Neoplasms; Malignant neoplasm of ovary; Mentors; Mission; Molecular; National Cancer Institute; Neoplasm Metastasis; Pathway interactions; Peer Review; Program Research Project Grants; Publications; Recruitment Activity; Research; Research Personnel; Resource Sharing; Role; Scientist; Signal Transduction; Therapeutic; Work; anticancer research; base; cancer diagnosis; cancer therapy; career development; disease diagnosis; melanoma; member; multidisciplinary; novel; patient oriented; programs; stem cell differentiation; tumor; tumor microenvironment; tumorigenesis

PROJECT SUMMARY (See instructions): The Molecular and Cellular Oncogenesis Program (MCO) is comprised of eleven investigators who work collaboratively in broad areas of cancer biology. Over the last budget period, the MCO Program has undergone an extensive realignment in research focus, thematic areas of collaboration and Program membership. In line with the strategic reorganization ofthe Cancer Center, the MCO Program appointed a new Program Leader (Dr. Murphy), recruited four new investigators at all academic ranks, and received one faculty member (Dr. Janicki) from the Gene Expression and Regulation (GER) Program. Concomitantly, three MCO members transferred to the newly created Program in Tumor Microenvironment and Metastasis (TMM). As a result, the MCO Program is now a more focused and highly collaborative research initiative, bringing together multidisciplinary expertise around three general flagship themes: Mechanisms of growth control (i); Cancer biomarkers and bio-signatures (ii); and Targeted cancer therapeutics (iii). The overarching goal of the Program is to combine a mechanistic understanding of cancer signaling networks with novel molecular approaches to disease diagnosis and treatment, along the continuum of basic, translational and patient-oriented cancer research. Synergy among the scientists is facilitated by a strong programmatic foundation in computational and integrative biology, a broad utilization of Cancer Center Shared Resources, and productive inter-programmatic and inter-institutional collaborations. Over the last budget period, MCO investigators made impressive gains on a broad portfolio of scientific discoveries in line with Program goals. The National Cancer Institute (NCI) funding base of the Program has grown by 27% compared to the last budget period, from $2.05 million in 2008 to $2.79 million in 2013 (direct costs), and the rate of collaborative publications has increased by more than five-fold, from 6.9% in 2008 to 36% in 2013 (total of intra- and inter-programmatic publications), with a total of 187 peer-reviewed cancer-relevant publications. MCO investigators continue to lead large programmatic and disease-relevant collaborations (Program Project grants, SPORE), contribute substantially to the translational mission of the Cancer Center in the Melanoma and Ovarian Cancer Research Continuum Signatures, and actively participate in education, mentoring and career development of faculty and trainees. The MCO Program will continue to build on these strengths during the next budget period, further expanding its unifying role as a multidisciplinary hub for basic and translational cancer research.

项目总结（见说明）： 分子和细胞肿瘤发生计划（MCO）由11名研究人员组成，他们在癌症生物学的广泛领域合作。在上一个预算期间，MCO计划在研究重点，合作主题领域和计划成员方面进行了广泛的调整。为了配合癌症中心的战略重组，MCO项目任命了一位新的项目负责人（Murphy博士），在所有学术级别招募了四名新的研究人员，并从基因表达和调控（格尔）项目接收了一名教员（Janicki博士）。同时，三名MCO成员转移到新创建的肿瘤微环境和转移（TMM）计划。因此，MCO计划现在是一个更加集中和高度合作的研究计划，围绕三个主要主题汇集了多学科专业知识：生长控制机制（i）;癌症生物标志物和生物特征（ii）;和靶向癌症治疗（iii）。该计划的总体目标是将联合收割机对癌症信号网络的机械理解与疾病诊断和治疗的新分子方法结合起来，沿着基础，转化和以患者为导向的癌症研究的连续体。科学家之间的协同作用是由计算和综合生物学，癌症中心共享资源的广泛利用，以及富有成效的跨计划和跨机构的合作强大的程序基础促进。在上一个预算期间，MCO调查人员在符合计划目标的广泛科学发现组合方面取得了令人印象深刻的成果。该计划的国家癌症研究所（NCI）资金基础与上一个预算期相比增长了27%，从2008年的205万美元增长到2013年的279万美元（直接费用），合作出版物的比率增加了五倍多，从2008年的6.9%上升到2013年的36%（方案内和方案间出版物总数），共有187份同行评审的癌症相关出版物。MCO研究人员继续领导大型项目和疾病相关的合作（计划项目赠款，SPORE），为癌症中心在黑色素瘤和卵巢癌研究连续体签名中的翻译使命做出重大贡献，并积极参与教师和学员的教育，指导和职业发展。在下一个预算期间，MCO计划将继续加强这些优势，进一步扩大其作为基础和转化癌症研究多学科中心的统一作用。