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Multiplexed Assays for Improving Rheumatoid Arthritis Diagnostics

Multiplexed Assays for Improving Rheumatoid Arthritis Diagnostics
改善类风湿关节炎诊断的多重检测
批准号：
8833870
负责人：
MARK S. CHEE
金额：
$22.47万
依托单位：
PROGNOSYS BIOSCIENCES, INC.
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
项目状态：
已结题
起止时间：
2014-09-18 至 2016-08-31
来源：
https://reporter.nih.gov/project-details/8833870
关键词：
AddressAffinityAmino AcidsAntibodiesAntigensAutoantibodiesAutoantigensAutoimmunityBiologicalBiological AssayBiological MarkersCharacteristicsCitrullineClassificationClinicClinicalCollaborationsCompanionsDNADNA LibraryDecision MakingDetectionDevelopmentDiagnosisDiagnosticDiagnostic SensitivityDiseaseEarly DiagnosisEconomicsEnzyme-Linked Immunosorbent AssayGoalsHeterogeneityHourImmune responseImmunoassayLaboratoriesMeasuresMethodsMonitorMorbidity - disease rateNatureNoisePatientsPeptide antibodiesPeptidesPerformancePharmaceutical PreparationsPhasePost-Translational Protein ProcessingPriceProductivityRecording of previous eventsResearch PersonnelRheumatoid ArthritisSamplingSensitivity and SpecificitySerumSignal TransductionSpecificityStagingSurveysSystemTechnologyTestingTherapeuticTimeantigen bindingarthritis therapychronic autoimmune diseaseclinical decision-makingclinically relevantcohortcyclic citrullinated peptidedesigndigitalhomocitrullineimprovedinnovative technologiesmeetingsnew technologynext generation sequencingnovel strategiesoutcome forecastpatient populationpublic health relevanceresponsescreeningsingle moleculetool

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英文摘要
DESCRIPTION (provided by applicant): There is a need for multiplexed assay technologies that enable diagnostics and detailed characterization of rheumatoid arthritis. In this project we plan to discover new rheumatoid arthritis biomarkers and implement them in a panel of multiplexed assays. We propose a novel approach that offers significant advances over existing methods, including the ability to rapidly develop, validate, and implement highly multiplexed, high- performance assays. If successful, our long-term goal is to transfer these new assays to the clinic as valuable new tools for high sensitivity diagnostics and treatment decision- making.
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Multiplexed Protein Assays
  • 批准号：
    8648596
  • 项目类别：
  • 资助金额：
    $35.0万
  • 财政年份：
    2014
  • 负责人：
    MARK S. CHEE
  • 依托单位：
    PROGNOSYS BIOSCIENCES, INC.
A High Throughput Assay for MHC-Peptide Interactions
  • 批准号：
    8593060
  • 项目类别：
  • 资助金额：
    $22.38万
  • 财政年份：
    2013
  • 负责人：
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    8669019
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  • 财政年份：
    2013
  • 负责人：
    MARK S. CHEE
  • 依托单位：
    PROGNOSYS BIOSCIENCES, INC.
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  • 批准号：
    8252248
  • 项目类别：
  • 资助金额：
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  • 财政年份：
    2012
  • 负责人：
    MARK S. CHEE
  • 依托单位：
    PROGNOSYS BIOSCIENCES, INC.
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