Highly Multiplexed Digital Assays

高度多重数字化分析

• 批准号: 8660699
• 负责人: MARK S. CHEE
• 金额: $ 57.48万
• 依托单位: PROGNOSYS BIOSCIENCES, INC.
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-01-15 至 2016-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8660699
• 关键词: Address; Affinity; Antibodies; Antigens; Area; Autoantibodies; Basic Science; Binding; Biological; Biological Assay; Biological Markers; Biological Models; Blinded; Cancer Patient; Clinic; Clinical; Collection; DNA; Detection; Development; Diagnosis; Diagnostic; Disease; Enzyme-Linked Immunosorbent Assay; Generations; Goals; High Pressure Liquid Chromatography; Hour; Human; Immunoassay; Individual; Laboratories; Malignant Neoplasms; Malignant neoplasm of lung; Methods; Oligonucleotides; Pattern; Performance; Phase; Process; Proteins; Reagent; Sampling; Screening for cancer; Serum; Solid; Staging; Techniques; Technology; Testing; Time; Validation; clinical decision-making; design; digital; disorder prevention; improved; innovation; lung cancer screening; member; new technology; next generation sequencing; novel; public health relevance; single molecule; tool

DESCRIPTION (provided by applicant): There is a need for new technologies to enable multiplexed analysis of collections of biomarkers in biological samples. We propose to develop a novel assay format for detecting and analyzing many biomarkers simultaneously. In order to do this we will develop reagents and methods and validate the approach using a model system. If successful, our long-term goal is to increase the level of multiplexing to enable analysis on a scale that is not feasible with current methods.

描述（由申请人提供）：需要新技术来实现对生物样本中生物标志物集合的多重分析。我们建议开发一种新的检测格式，同时检测和分析许多生物标志物。为了做到这一点，我们将开发试剂和方法，并使用模型系统验证该方法。如果成功，我们的长期目标是提高多路复用水平，以实现当前方法不可行的规模分析。