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Microarray Technology for Genomic Assays

Microarray Technology for Genomic Assays
用于基因组检测的微阵列技术
批准号：
7681320
负责人：
MARK S. CHEE
金额：
$61.22万
依托单位：
PROGNOSYS BIOSCIENCES, INC.
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
项目状态：
已结题
起止时间：
2007-05-21 至 2011-08-31
来源：
https://reporter.nih.gov/project-details/7681320
关键词：
AddressAmino Acid SequenceBiologicalBiological AssayBiologyChurchCloningCocosDNADNA ResequencingDNA SequenceDNA biosynthesisExcisionFungal GenomeGenesGenomeGenomicsGoalsHomologous GeneHumanLawsLengthMethodsMicroarray AnalysisMiniaturizationOligonucleotide PrimersOligonucleotidesPeptide Sequence DeterminationPhasePreclinical Drug EvaluationPreparationProcessResearch PersonnelSNP genotypingSamplingSynthesis ChemistrySynthetic GenesTechniquesTechnologyTestingYeastsbasecostdesignflexibilitygene synthesishigh throughput screeninghomologous recombinationnew technologynovelsynthetic biology

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中文摘要
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英文摘要
DESCRIPTION (provided by applicant): Access to DNA sequence information on a genomic scale has enabled the design of ever-larger sets of oligonucleotides (oligos) for a wide variety of high-throughput assays. The ability to go directly from sequence information to synthetic oligos has been a cornerstone of many key advances in genomics. However, although the cost of oligo synthesis has decreased dramatically, it is still too expensive for many applications. We propose to address this major need in genomics. This Phase II proposal aims to develop a novel, inexpensive, highly flexible and efficient approach for manufacturing oligos and to demonstrate its utility in key applications in genomics.
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