Center for Protease Research

蛋白酶研究中心

• 批准号: 8701303
• 负责人: MUKUND P. SIBI
• 金额: $ 104.05万
• 依托单位: NORTH DAKOTA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-24 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8701303
• 关键词: American Heart Association; Applications Grants; Asthma; Award; Biology; Biomedical Research; Centers of Research Excellence; Core Facility; Data; Department of Defense; Development; Diabetes Mellitus; Disease; Education; Environment; Extramural Activities; Faculty; Funding; Funding Opportunities; Goals; Grant; Human Resources; Interdisciplinary Study; Lead; Malignant Neoplasms; Mentors; Molecular Biology; North Dakota; Outcome; Peer Review; Peptide Hydrolases; Phase; Pilot Projects; Publications; Publishing; Request for Proposals; Research; Research Personnel; Research Project Grants; Research Support; Resources; Role; Services; Strategic Planning; Technology; Training; United States National Institutes of Health; Universities; Ursidae Family; human disease; improved; member; programs; public health relevance

DESCRIPTION (provided by applicant): This is a proposal requesting Phase III support for five years to continue our successful COBRE Center for Protease Research (CPR) at North Dakota State University (NDSU), which was established in 2001 with Phase I of grant P20RR15566. The overarching goal for the Center is to obtain fundamental understanding of the role of proteases in disease in the broadest sense. During the first ten years, the Center has funded twenty-seven faculty researchers and established two core facilities. Several of these faculty members have received major research funding awards from NIH and NSF (R01, CAREER, and Presidential Young Investigator Awards) and the majority of the junior faculty have successfully competed for NIH (R03, R15, and R21), American Heart Association, or Department of Defense grants. In total, the Center PIs have received more than $17,500,000 in new funding and an additional $1,000,000 in education grants. The PIs from the Center have published 335 peer-reviewed publications since 2001. The strategic plan for Phase III of the CPR COBRE Center during the next five years is (1) to maintain and strengthen the state-of-the-art Core Biology and Core Synthesis Facilities established during Phases I and II that are essential for the support of the research projects in the Center, (2) to support research pilot projects and training components to sustain a collaborative, multidisciplinary research environment, (3) to provide significant mentoring in professional activities for the development of junior faculty members, and (4) to maintain an administrative core that will be required to coordinate and evaluate the entire program, including the Pilot Project Program and the two research cores. In this application, the Center for Protease Research is requesting funds to continue its support of two core facilities, to establish a new Pilot Project Program for biomedical research, and an Administrative Core to coordinate these activities. NDSU has clearly recognized the tremendous resources the Center brings to bear on its continued development as a research-intensive university. Over the course of the requested Phase III grant, NDSU will contribute $1,250,000 in direct support of the Center.

描述（由申请人提供）：本提案请求为期五年的第三阶段支持，以继续我们在北达科他州立大学 (NDSU) 成功开展的 COBRE 蛋白酶研究 (CPR) 中心，该中心成立于 2001 年，第一阶段拨款 P20RR15566。该中心的首要目标是从最广泛的意义上获得对蛋白酶在疾病中的作用的基本了解。在第一个十年中，该中心资助了 27 名教员研究人员，并建立了两个核心设施。其中几位教职人员获得了 NIH 和 NSF 的重大研究资助奖项（R01、CAREER 和总统青年研究者奖），大多数初级教职人员已成功竞争 NIH（R03、R15 和 R21）、美国心脏协会或国防部的资助。中心 PI 总共获得了超过 17,500,000 美元的新资金以及另外 1,000,000 美元的教育补助金。自 2001 年以来，该中心的 PI 已发表了 335 篇同行评审出版物。未来五年 CPR COBRE 中心第三阶段的战略计划是 (1) 维持和加强第一阶段和第二阶段建立的最先进的核心生物学和核心合成设施，这对于支持中心的研究项目至关重要，(2) 支持研究试点项目和培训部分，以维持合作、 多学科研究环境，（3）为专业活动的发展提供重要指导 (4) 维持一个行政核心，以协调和评估整个项目，包括试点项目和两个研究核心。 在本申请中，蛋白酶研究中心请求资金继续支持两个核心设施，建立一个新的生物医学研究试点项目计划，以及一个协调这些活动的行政核心。 NDSU 清楚地认识到该中心为其作为研究密集型大学的持续发展所带来的巨大资源。在请求的第三阶段拨款期间，NDSU 将捐赠 1,250,000 美元直接支持该中心。