COBRE: NDSU: ADMIN: NEW STRATEGIES FOR TARGETING PROTEASE IN DISEASE

COBRE：NDSU：管理员：针对疾病中的蛋白酶的新策略

• 批准号: 8167859
• 负责人: MUKUND P. SIBI
• 金额: $ 101.81万
• 依托单位: NORTH DAKOTA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167859
• 关键词: Applications Grants; Asthma; Biological; Biology; Biomedical Research; Centers of Research Excellence; Chemistry; Computer Retrieval of Information on Scientific Projects Database; Core Facility; Disease; Fostering; Funding; Goals; Grant; Growth; Histones; Human; Institution; Malignant Neoplasms; Matrix Metalloproteinases; Molecular Biology; North Dakota; Peptide Hydrolases; Pharmacologic Substance; Play; Research; Research Infrastructure; Research Personnel; Resources; Role; Science; Source; Synthesis Chemistry; United States National Institutes of Health; biomedical scientist; combat; cooking; mortality; novel therapeutics; programs

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Center for Protease Research was established in 2001 with funds from the COBRE program. The previous grant application had a strong focus on chemistry, while this continuation will have a strong biology component with cancer and asthma as the primary disease targets. Understanding the biological role played by matrix metalloproteinases and histone deacetylases in cancer and other diseases such as asthma will be a major scientific goal. The Center will coordinate the expertise of 4 new investigators: Glenn Dorsam and Gregory Cook, Department of Chemistry and Molecular Biology; Bin Guo, Department of Pharmaceutical Sciences; and Jane Schuh, Department of Veterinary and Microbiological Sciences. Core Facilities in biology and synthetic chemistry will play a key role in assisting the research programs of the new PI's, other NDSU researchers, and North Dakota INBRE researchers. The Center will continue to build infrastructure, initiate new activities, and continue previously successful programs to foster growth of biomedical research in North Dakota. Combating cancer, one of the leading causes of mortality in humans, is a major goal for biomedical scientists. The NDSU COBRE center will conduct research to provide fundamental information on how proteases, a key biological player in several diseases, impacts cancer. These studies have the potential to provide novel therapeutics that can treat this deadly disease.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 蛋白酶研究中心于 2001 年在 COBRE 计划的资助下成立。之前的拨款申请重点关注化学，而这次的延续将具有强大的生物学成分，以癌症和哮喘作为主要疾病目标。了解基质金属蛋白酶和组蛋白脱乙酰酶在癌症和哮喘等其他疾病中发挥的生物学作用将是一个主要的科学目标。 该中心将协调 4 名新研究人员的专业知识：化学与分子生物学系的 Glenn Dorsam 和 Gregory Cook；郭斌，药学系；和 Jane Schuh，兽医和微生物科学系。生物学和合成化学方面的核心设施将在协助新 PI、其他 NDSU 研究人员和北达科他州 INBRE 研究人员的研究项目方面发挥关键作用。该中心将继续建设基础设施，开展新的活动，并继续之前成功的项目，以促进北达科他州生物医学研究的发展。 癌症是人类死亡的主要原因之一，抗击癌症是生物医学科学家的主要目标。 NDSU COBRE 中心将开展研究，提供有关蛋白酶（多种疾病的关键生物参与者）如何影响癌症的基本信息。这些研究有可能提供治疗这种致命疾病的新疗法。