COBRE: NDSU: ADMIN: NEW STRATEGIES FOR TARGETING PROTEASE IN DISEASE

COBRE：NDSU：管理员：针对疾病中的蛋白酶的新策略

• 批准号: 8360592
• 负责人: MUKUND P. SIBI
• 金额: $ 100.79万
• 依托单位: NORTH DAKOTA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2012-09-23
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8360592
• 关键词: Applications Grants; Asthma; Biological; Biology; Biomedical Research; Centers of Research Excellence; Chemistry; Core Facility; Disease; Fostering; Funding; Goals; Grant; Growth; Histones; Human; Malignant Neoplasms; Matrix Metalloproteinases; Molecular Biology; National Center for Research Resources; North Dakota; Peptide Hydrolases; Pharmacologic Substance; Play; Principal Investigator; Research; Research Infrastructure; Research Personnel; Resources; Role; Science; Source; Synthesis Chemistry; United States National Institutes of Health; biomedical scientist; combat; cooking; cost; mortality; novel therapeutics; programs

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The Center for Protease Research was established in 2001 with funds from the COBRE program. The previous grant application had a strong focus on chemistry, while this continuation will have a strong biology component with cancer and asthma as the primary disease targets. Understanding the biological role played by matrix metalloproteinases and histone deacetylases in cancer and other diseases such as asthma will be a major scientific goal. The Center will coordinate the expertise of 4 new investigators: Glenn Dorsam and Gregory Cook, Department of Chemistry and Molecular Biology; Bin Guo, Department of Pharmaceutical Sciences; and Jane Schuh, Department of Veterinary and Microbiological Sciences. Core Facilities in biology and synthetic chemistry will play a key role in assisting the research programs of the new PI's, other NDSU researchers, and North Dakota INBRE researchers. The Center will continue to build infrastructure, initiate new activities, and continue previously successful programs to foster growth of biomedical research in North Dakota. Combating cancer, one of the leading causes of mortality in humans, is a major goal for biomedical scientists. The NDSU COBRE center will conduct research to provide fundamental information on how proteases, a key biological player in several diseases, impacts cancer. These studies have the potential to provide novel therapeutics that can treat this deadly disease.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 蛋白酶研究中心成立于2001年，资金来自COBRE计划。以前的拨款申请重点关注化学，而这次延续将有很强的生物学成分，癌症和哮喘是主要的疾病目标。了解基质金属蛋白酶和组蛋白脱乙酰酶在癌症和其他疾病（如哮喘）中的生物学作用将是一个主要的科学目标。 该中心将协调4名新研究人员的专业知识：化学和分子生物学系的Glenn Dorsam和Gregory Cook;药物科学系的Bin Guo;兽医和微生物科学系的Jane Schuh。生物学和合成化学的核心设施将在协助新PI、其他NDSU研究人员和北达科他州INBRE研究人员的研究计划方面发挥关键作用。该中心将继续建设基础设施，开展新的活动，并继续以前成功的计划，以促进生物医学研究在北达科他州的增长。 癌症是人类死亡的主要原因之一，防治癌症是生物医学科学家的主要目标。NDSU COBRE中心将进行研究，以提供关于蛋白酶如何影响癌症的基本信息，蛋白酶是几种疾病中的关键生物作用者。这些研究有可能提供治疗这种致命疾病的新疗法。