COBRE: NDSU: ADMIN: NEW STRATEGIES FOR TARGETING PROTEASE IN DISEASE

COBRE：NDSU：管理员：针对疾病中的蛋白酶的新策略

• 批准号: 8360592
• 负责人: MUKUND P. SIBI
• 金额: $ 100.79万
• 依托单位: NORTH DAKOTA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2012-09-23
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8360592
• 关键词: Applications Grants; Asthma; Biological; Biology; Biomedical Research; Centers of Research Excellence; Chemistry; Core Facility; Disease; Fostering; Funding; Goals; Grant; Growth; Histones; Human; Malignant Neoplasms; Matrix Metalloproteinases; Molecular Biology; National Center for Research Resources; North Dakota; Peptide Hydrolases; Pharmacologic Substance; Play; Principal Investigator; Research; Research Infrastructure; Research Personnel; Resources; Role; Science; Source; Synthesis Chemistry; United States National Institutes of Health; biomedical scientist; combat; cooking; cost; mortality; novel therapeutics; programs

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The Center for Protease Research was established in 2001 with funds from the COBRE program. The previous grant application had a strong focus on chemistry, while this continuation will have a strong biology component with cancer and asthma as the primary disease targets. Understanding the biological role played by matrix metalloproteinases and histone deacetylases in cancer and other diseases such as asthma will be a major scientific goal. The Center will coordinate the expertise of 4 new investigators: Glenn Dorsam and Gregory Cook, Department of Chemistry and Molecular Biology; Bin Guo, Department of Pharmaceutical Sciences; and Jane Schuh, Department of Veterinary and Microbiological Sciences. Core Facilities in biology and synthetic chemistry will play a key role in assisting the research programs of the new PI's, other NDSU researchers, and North Dakota INBRE researchers. The Center will continue to build infrastructure, initiate new activities, and continue previously successful programs to foster growth of biomedical research in North Dakota. Combating cancer, one of the leading causes of mortality in humans, is a major goal for biomedical scientists. The NDSU COBRE center will conduct research to provide fundamental information on how proteases, a key biological player in several diseases, impacts cancer. These studies have the potential to provide novel therapeutics that can treat this deadly disease.

这个子项目是利用这些资源的众多研究子项目之一