Center for Protease Research

蛋白酶研究中心

• 批准号: 8305254
• 负责人: MUKUND P. SIBI
• 金额: $ 85.09万
• 依托单位: NORTH DAKOTA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-24 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8305254
• 关键词: American Heart Association; Applications Grants; Asthma; Award; Biology; Biomedical Research; Centers of Research Excellence; Core Facility; Data; Department of Defense; Development; Diabetes Mellitus; Disease; Education; Environment; Extramural Activities; Faculty; Funding; Funding Opportunities; Goals; Grant; Human Resources; Interdisciplinary Study; Lead; Malignant Neoplasms; Mentors; Molecular Biology; North Dakota; Outcome; Peer Review; Peptide Hydrolases; Phase; Pilot Projects; Publications; Publishing; Request for Proposals; Research; Research Personnel; Research Project Grants; Research Support; Resources; Role; Services; Strategic Planning; Technology; Training; United States National Institutes of Health; Universities; Ursidae Family; human disease; improved; member; programs

DESCRIPTION (provided by applicant): This is a proposal requesting Phase III support for five years to continue our successful COBRE Center for Protease Research (CPR) at North Dakota State University (NDSU), which was established in 2001 with Phase I of grant P20RR15566. The overarching goal for the Center is to obtain fundamental understanding of the role of proteases in disease in the broadest sense. During the first ten years, the Center has funded twenty-seven faculty researchers and established two core facilities. Several of these faculty members have received major research funding awards from NIH and NSF (R01, CAREER, and Presidential Young Investigator Awards) and the majority of the junior faculty have successfully competed for NIH (R03, R15, and R21), American Heart Association, or Department of Defense grants. In total, the Center PIs have received more than $17,500,000 in new funding and an additional $1,000,000 in education grants. The PIs from the Center have published 335 peer-reviewed publications since 2001. The strategic plan for Phase III of the CPR COBRE Center during the next five years is (1) to maintain and strengthen the state-of-the-art Core Biology and Core Synthesis Facilities established during Phases I and II that are essential for the support of the research projects in the Center, (2) to support research pilot projects and training components to sustain a collaborative, multidisciplinary research environment, (3) to provide significant mentoring in professional activities for the development of junior faculty members, and (4) to maintain an administrative core that will be required to coordinate and evaluate the entire program, including the Pilot Project Program and the two research cores. In this application, the Center for Protease Research is requesting funds to continue its support of two core facilities, to establish a new Pilot Project Program for biomedical research, and an Administrative Core to coordinate these activities. NDSU has clearly recognized the tremendous resources the Center brings to bear on its continued development as a research-intensive university. Over the course of the requested Phase III grant, NDSU will contribute $1,250,000 in direct support of the Center. PUBLIC HEALTH RELEVANCE (provided by applicant): All of the research projects supported by our Center are directed toward obtaining a fundamental understanding of the role of proteases in disease. Successful outcome of these activities should lead to improved treatments of human diseases such as cancer, asthma, and diabetes.

描述(由申请人提供)：这是一份申请第三阶段支持的建议书，为期五年，以继续我们在北达科他州州立大学(NDSU)成功的科布雷蛋白酶研究中心(CPR)，该中心成立于2001年，第一阶段拨款为P20RR15566。该中心的首要目标是在最广泛的意义上从根本上了解蛋白酶在疾病中的作用。在最初的十年里，该中心资助了27名教职员工研究人员，并建立了两个核心设施。其中几名教员获得了NIH和NSF颁发的主要研究经费奖(R01、Career和总统青年研究员奖)，大多数初级教员成功地竞争了NIH(R03、R15和R21)、美国心脏协会或国防部的拨款。中心绩效指标总共收到了超过17500,000美元的新资金和额外的1,000,000美元的教育补助金。自2001年以来，该中心的私人投资机构出版了335份同行评议的出版物。未来五年，CPR Cobre中心第三阶段的战略计划是：(1)维护和加强在第一和第二阶段建立的最先进的核心生物学和核心合成设施，这些设施对支持中心的研究项目至关重要；(2)支持研究试点项目和培训部分，以维持一个协作的、多学科的研究环境；(3)为发展 (4)保持一个行政核心，以协调和评估整个计划，包括试点项目计划和两个研究核心。 在这项申请中，蛋白水解酶研究中心正在申请资金，以继续支持两个核心设施，建立一个新的生物医学研究试点项目计划，以及一个协调这些活动的行政核心。南洋理工大学清楚地认识到该中心为其作为一所研究密集型大学的持续发展所带来的巨大资源。在申请的第三阶段赠款期间，国家发展和工业大学将捐助1,250,000美元，直接支持该中心。 公共卫生相关性(由申请者提供)：我们中心支持的所有研究项目都旨在从根本上了解蛋白酶在疾病中的作用。这些活动的成功结果应该会改善人类疾病的治疗，如癌症、哮喘和糖尿病。