New Strategies for Targeting Protease in Disease

描述(由申请人提供)：这项提案寻求资金，以继续在北达科他州州立大学建立一个具有全国竞争力的生物医学研究中心，专注于疾病中的蛋白酶研究。2001年，在科布雷计划的资助下，成立了蛋白酶研究中心。它目前已进入融资的第六个年头。上一次的拨款申请重点放在化学上，而这次续签申请将有很强的生物学成分，癌症和哮喘是主要的疾病目标。了解基质金属蛋白酶和组蛋白脱乙酰酶在癌症和哮喘等其他疾病中所起的生物学作用将是一个主要的科学目标。 该中心将协调五名新调查人员的专业知识：格雷戈里·库克、格伦·多萨姆、埃米利奥·埃斯波西托，化学和分子生物学系，郭斌，药学系，以及简·舒赫，兽医和微生物科学系。一名在生物学领域具有专业知识并有指导初级教员的经验的高级教员将在拟议的资助期的第一年招聘。生物和合成化学方面的核心设施将在协助新的PIS的研究计划、前一批拨款期间启动的研究计划、其他北达科他州州立大学研究人员和北达科他州INBRE研究人员方面发挥关键作用。科布雷中心将继续建设基础设施，启动新的活动，并继续成功地实施以前的计划，以促进北达科他州生物医学研究的增长。 抗击癌症是人类死亡的主要原因之一，也是生物医学科学家的主要目标。NDSU-Cobre中心将进行研究，提供有关蛋白酶如何影响癌症的基本信息。蛋白酶是几种疾病的关键生物学参与者。这些研究有可能提供治疗这种致命疾病的新疗法。

DESCRIPTION (provided by applicant): This proposal seeks funding to continue a nationally competitive biomedical research center in North Dakota State University focused on the study of proteases in disease. The Center for Protease Research was established in 2001 with funds from the COBRE program. It is currently in its sixth year of funding. The previous grant application had a strong focus on chemistry while this renewal application will have a strong biology component with cancer and asthma as the primary disease targets. Understanding the biological role played by matrix metalloproteinases and histone deacetylases in cancer and other diseases such as asthma will be a major scientific goal. The Center will coordinate the expertise of five new investigators: Gregory Cook, Glenn Dorsam, Emilio Esposito, Department of Chemistry and Molecular Biology, Bin Guo, Department of Pharmaceutical Sciences and Jane Schuh, Department of Veterinary and Microbiological Sciences. A senior faculty member with expertise in the biology area, and experience to mentor the junior faculty members, will be recruited in the first year of the proposed grant period. Core facilities in biology and synthetic chemistry will play a key role in assisting the research programs of the new Pis, research programs that were initiated during the previous grant period, other NDSU researchers, and North Dakota INBRE researchers. The COBRE Center will continue to build infrastructure, initiate new activities, and continue successful previous programs to foster growth of biomedical research in North Dakota. Combating cancer, one of the leading causes of mortality in humans, is a major goal for biomedical scientists. The NDSU-COBRE center will conduct research to provide fundamental information on how proteases, a key biological player in several diseases, impacts cancer. These studies have the potential to provide novel therapeutics that can treat this deadly disease.