COBRE: NDS U: ADMIN: NEW STRATEGIES FOR TARGETING PROTEASES IN DISEASE

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 研究中心，而研究中心不一定是研究者所在的机构。 该计划将包括三个项目和一个中央核心设施，每个项目都涉及总体目标的一个关键方面。该中心的重点将是开发基质蛋白酶的治疗性抑制剂，其中包括锌依赖性基质金属酶（MMP）家族，丝氨酸蛋白酶（SP），尿激酶纤溶酶原激活剂（uPA）和纤溶酶。该项目的主要工作是抑制MMP。但是，这两种丝氨酸蛋白酶在健康和疾病中的基质稳态中也起着关键作用。一部分的努力将针对这些酶的抑制剂的设计和优化。这项工作将包括四个相互关联的项目。北达科他州和其他EPSCoR州一样，没有向NIH提交足够的提案。为了解决这个问题，COBRE中心将把其预算的很大一部分用于人力资源。该中心将通过为新的体内生物学家提供启动资金来增加具有生物医学研究兴趣的教师数量。该中心的研究活动将为北达科他州带来合格的技术人员、博士后和学生。此外，该中心将启动几个项目，以增加该州的生物医学研究。这些举措包括：为北达科他州教师提供种子赠款，建立研究生奖学金计划，为4年制大学的本科生和教师提供博士后奖学金夏季研究计划，以及NIH研讨会。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The program will consist of three projects and a central core facility with each addressing a critical aspect of the overall goal. The focus of the Center will be the development of therapeutic inhibitors for matrix proteinases, which include the family of zinc-dependent matrix metalloenzymes (MMP's), and the serine proteases (SP's), urokinase plasminogen activator (uPA) and plasmin. The majority of effort of this project is the inhibition of MMP's. But, the two serine proteases also play critical roles in matrix homeostasis in both health and disease. A part of the effort will be directed towards the design and optimization of inhibitors for these enzymes. This effort will consist of four interrelated projects. North Dakota, like other EPSCoR states, does not submit enough proposals to NIH. To address this problem, the COBRE Center will dedicate a large part of its budget to Human Resources. This center will increase the number of faculty with biomedical research interests by providing startup funds for a new in vivo biologist. Research activities in the Center will bring to North Dakota qualified technicians, postdoctoral associates, and students. Additionally, the center will initiate several programs to increase biomedical research in the state. These initiatives include : seed grants for North Dakota faculty, establishment of a graduate fellowship program, post-doctoral fellowships summer research program for undergraduates and faculty from 4-year colleges, and NIH workshops.