COBRE: NDS U: ADMIN: NEW STRATEGIES FOR TARGETING PROTEASES IN DISEASE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 该方案将由三个项目和一个中央核心设施组成，每个项目都涉及总体目标的一个关键方面。该中心的重点将是开发治疗基质蛋白酶的抑制剂，包括锌依赖的基质金属酶(MMPs)家族，以及丝氨酸蛋白酶(SP‘s)、尿激酶型纤溶酶原激活剂(UPA)和纤溶酶。这个项目的主要工作是抑制基质金属蛋白酶。但是，这两种丝氨酸蛋白酶在健康和疾病中也在基质动态平衡中起着关键作用。部分工作将针对这些酶的抑制剂的设计和优化。这项工作将由四个相互关联的项目组成。北达科他州和其他EPSCoR州一样，没有向NIH提交足够的提案。为了解决这一问题，科布雷中心将把很大一部分预算用于人力资源。该中心将通过为一名新的活体生物学家提供启动资金来增加具有生物医学研究兴趣的教职员工数量。该中心的研究活动将为北达科他州带来合格的技术人员、博士后助理和学生。此外，该中心将启动几个项目，以增加该州的生物医学研究。这些举措包括：为北达科他州教师提供种子赠款，设立研究生奖学金计划，为四年制大学本科生和教职员工提供博士后奖学金暑期研究计划，以及NIH研讨会。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The program will consist of three projects and a central core facility with each addressing a critical aspect of the overall goal. The focus of the Center will be the development of therapeutic inhibitors for matrix proteinases, which include the family of zinc-dependent matrix metalloenzymes (MMP's), and the serine proteases (SP's), urokinase plasminogen activator (uPA) and plasmin. The majority of effort of this project is the inhibition of MMP's. But, the two serine proteases also play critical roles in matrix homeostasis in both health and disease. A part of the effort will be directed towards the design and optimization of inhibitors for these enzymes. This effort will consist of four interrelated projects. North Dakota, like other EPSCoR states, does not submit enough proposals to NIH. To address this problem, the COBRE Center will dedicate a large part of its budget to Human Resources. This center will increase the number of faculty with biomedical research interests by providing startup funds for a new in vivo biologist. Research activities in the Center will bring to North Dakota qualified technicians, postdoctoral associates, and students. Additionally, the center will initiate several programs to increase biomedical research in the state. These initiatives include : seed grants for North Dakota faculty, establishment of a graduate fellowship program, post-doctoral fellowships summer research program for undergraduates and faculty from 4-year colleges, and NIH workshops.