NIMH Psychoactive Drug Screening Program

NIMH 精神活性药物筛选计划

• 批准号: 8898656
• 负责人: Bryan L. Roth
• 金额: $ 254.66万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-30 至 2018-08-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8898656
• 关键词: Address; Basic Science; Behavioral; Biochemical; Biological Assay; Biological Factors; Brain imaging; Cells; Chemicals; Chemistry; Clinical Research; Code; Communities; Contractor; Contracts; Data; Data Files; Development; Drug Delivery Systems; Enzyme Inhibitor Drugs; Enzyme Inhibitors; Functional Magnetic Resonance Imaging; Funding; Genes; Human; Individual; Lead; Libraries; Ligands; Mental disorders; National Institute of Mental Health; Positron-Emission Tomography; Preclinical Drug Evaluation; Proteins; Psychotropic Drugs; Research; Research Personnel; Rodent; Sampling; Services; Source; Specific qualifier value; Specificity; Testing; Therapeutic; Therapeutic Agents; Tissues; United States National Institutes of Health; Vial device; analog; base; combinatorial; design; electronic data; novel; programs; receptor; screening; single photon emission computed tomography; small molecule; tool

The purpose of the NIMH Psychoactive Drug Screening Program is to provide screening of novel synthetic compounds and natural products for potential use as research tools or probes for basic and clinical research, as therapeutic agents for mental disorders, and as PET, SPECT, and fMRI ligands for functional brain imaging. This program is primarily intended as a screen for compounds that have previously been shown to possess pharmacological, biochemical, or behavioral activities relevant to NIMH and not for the purpose of large-scale, random screening of natural products or combinatorial libraries. However, limited screening may also be conducted on small libraries of synthetic or natural product compounds of unknown activity and on hit or lead compounds generated through NIH-funded HTS or chemistry programs. Compounds will be provided by the research community, primarily NIH-supported investigators. It is anticipated that the Contractor will receive and screen compounds on a continuous and on-going basis, although the volume of requests will vary from month to month.

NIMH精神活性药物筛选计划的目的是提供新的合成化合物和天然产物的筛选，这些化合物和天然产物可能用作基础和临床研究的研究工具或探针，作为精神障碍的治疗剂，以及作为PET，SPECT和功能性脑成像的fMRI配体。该程序主要用于筛选先前已显示具有与NIMH相关的药理学，生物化学或行为活性的化合物，而不是用于大规模随机筛选天然产物或组合文库。然而，也可以对活性未知的合成或天然产物化合物的小文库以及通过NIH资助的HTS或化学程序产生的命中或先导化合物进行有限的筛选。化合物将由研究界提供，主要是NIH支持的研究人员。预计承包商将持续不断地接收和筛选化合物，尽管每月的申请量各不相同。