K07 Leadership Grant

K07 领导力补助金

• 批准号: 8672577
• 负责人: SHARON K. INOUYE
• 金额: $ 13.17万
• 依托单位: HEBREW REHABILITATION CENTER FOR AGED
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-01 至 2018-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8672577
• 关键词: Accounting; Acute; Address; Aging; American; Area; Award; Bibliography; Biological Markers; Boston; Clinical; Clinical Investigator; Clinical Trials Design; Cognition Disorders; Collaborations; Communities; Confusion; Databases; Delirium; Development; Diagnosis; Discipline; Educational process of instructing; Elderly; Expenditure; Family; Foundations; Genomics; Geriatrics; Gerontology; Goals; Grant; Group Meetings; Health; Health Care Costs; Healthcare; Hospitals; Institution; Interdisciplinary Study; Interest Group; Intervention; Knowledge; Lead; Leadership; Libraries; Life; Medicare; Mentorship; Morbidity - disease rate; NCI Scholars Program; Outcome; Patients; Preventive Intervention; Program Development; Program Sustainability; Qualifying; Quality of life; Rehabilitation Centers; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Training; Resources; Risk Factors; Series; Statistical Methods; Syndrome; Technology; Time; Training; Training Programs; Training Support; Translating; Translational Research; Ursidae Family; Visit; Work; career development; clinical care; clinically relevant; cost; didactic education; experience; improved; innovation; knowledge translation; longitudinal analysis; medical schools; meetings; mortality; neglect; neuroimaging; new technology; novel; outcome forecast; patient oriented research; prevent; programs; public health relevance; research and development; skills; special interest group; symposium; web site; working group

DESCRIPTION (provided by applicant): Over 2.5 million older Americans develop delirium (acute confusional state) each year, a common and serious geriatric syndrome, with associated mortality rates of 25-33% and accounting for >$100 billion in healthcare expenditures in the ensuing year. Yet, less than 30% of these cases are recognized, and even fewer receive proven preventive interventions. Clinical care to address and prevent delirium is deficient both because empirical evidence is lacking and because existing evidence is not consistently translated in an effective manner. The Candidate, Dr. Inouye, is an expert geriatrician and experienced clinical investigator, who has conducted ground-breaking work to advance our understanding of the diagnosis, risk factors, prognosis, and interventions for delirium. For this K07 Leadership Award, she proposes to develop the nation's first program focusing specifically on delirium in older adults, the "Center of Excellence for Delirium in Aging: Research, Training and Educational Enhancement (CEDARTREE)" to advance delirium research and training. She will establish this program at Harvard Medical School-Hebrew Rehabilitation Center, bringing together world-renowned resources in clinical-translational research, geriatrics/gerontology, and superb interdisciplinary expertise and resources to support the program, which will stimulate research across the greater Boston academic community. The specific aims are to: 1) To create a comprehensive interdisciplinary training and mentorship program in delirium research, including a formal didactic curriculum, seminar series, collaborative working groups, and individualized mentorship with experienced investigators; 2) To develop core resources to attract interdisciplinary investigators to engage in collaborative delirium-related research (e.g., website research development grants, access to novel research technologies and databases, investigator listserve, statistical/methodological expertise, and delirium bibliography); and 3) To serve as a local and national resource for research on delirium in aging through disseminating website resources and educational content, hosting a visiting scholar program, annual scientific symposium, interest groups at national meetings, and developing national linkages to translate evidence. Innovative approaches will be incorporated at every level of the program: translational research on delirium (biomarkers, genomics, advanced neuroimaging), advanced statistical methods to address methodological challenges, and innovative educational strategies (e.g., interactive on-line educational approaches). For Dr. Inouye, the K07 award will provide the opportunity for further career development in key leadership areas and protect time needed to develop, fully implement, evaluate, refine, and establish the self-sustaining infrastructure to assure continuation of the center as an enduring contribution to aging research and training. CEDARTREE represents the first resource of its kind, providing an innovative and much-needed local/national resource and focal point that will enhance the capacity for research on delirium in aging, with the ultimate goal of improving health and quality of life for seniors.

描述（由申请人提供）：每年有超过250万年长的美国人发展del妄（急性混乱状态），这是一种普通而严重的老年综合症，相关的死亡率为25-33％，在一年中的医疗保健支出中占1000亿美元。然而，这些案件中只有不到30％被认可，甚至更少的接受预防性干预措施。临床护理以解决和预防ir妄，这两者都缺乏，因为缺乏经验证据，并且由于现有证据并未以有效的方式持续翻译。候选人Inouye博士是一位专业的老年医生和经验丰富的临床研究者，他从事了开创性的工作，以促进我们对del妄诊断，危险因素，预后和干预措施的理解。为了获得这一K07领导奖，她建议制定美国第一个专门针对老年人del妄的计划，即“衰老del妄卓越中心：研究，培训和教育增强（Cedartree）”，以提高ir妄研究和培训。她将在哈佛医学学校康复中心建立该计划，将世界知名的资源汇集到临床译本研究，老年/老年学方面，以及超级跨学科的专业知识和资源来支持该计划，这将刺激整个波士顿学术界的研究。具体目的是：1）在ir妄研究中创建全面的跨学科培训和指导计划，包括正式的教学课程，研讨会系列，协作工作组以及与经验丰富的研究人员的个性化指导； 2）开发核心资源以吸引跨学科的研究人员参与与ir妄相关的研究（例如，网站研究开发赠款，访问新颖的研究技术和数据库，研究者列表列表，统计/方法论专业知识和delirium delirium参考书目）；和3）到 通过传播网站资源和教育内容，托管访问学者计划，年度科学研讨会，在国家会议上的利益集团以及建立国家联系以翻译证据，可以作为衰老del妄研究的本地和国家资源。创新方法将在该计划的各个层面上纳入：关于ir妄的转化研究（生物标志物，基因组学，先进的神经影像学），解决方法论挑战的先进统计方法以及创新的教育策略（例如，互动式在线教育方法）。对于Inouye博士来说，K07奖将为在关键领导领域的进一步职业发展提供机会，并保护开发，全面实施，评估，完善，完善和建立自我维持的基础设施，以确保中心继续持续，以作为对衰老研究和培训的持久贡献。 Cedartree代表了同类资源的第一个资源，它提供了一种创新且急需的本地/国家资源和焦点，这将增强对衰老del妄的研究能力，其最终目标是改善老年人的健康和生活质量。