The development of neural responses to punishment in adolescence
青春期对惩罚的神经反应的发展
基本信息
- 批准号:8662735
- 负责人:
- 金额:$ 37.93万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2013
- 资助国家:美国
- 起止时间:2013-06-01 至 2017-05-31
- 项目状态:已结题
- 来源:
- 关键词:12 year old19 year oldAddressAdolescenceAdolescentAdolescent and Young AdultAdultAgeAlcohol or Other Drugs useAmygdaloid structureAutomobile DrivingBehaviorBehavioralBrainBrain regionCessation of lifeChildChoice BehaviorCorpus striatum structureDecision MakingDevelopmentDiseaseDropsDrug AddictionDrug abuseDrug usageEventFeedbackFutureIllicit DrugsImpairmentIncentivesIndividualIndividual DifferencesInjuryInsula of ReilLeadLearningLifeLiteratureMagnetic Resonance ImagingMeasuresModelingNatureNegative FindingOutcomePlayPoliciesProcessPsychological reinforcementPunishmentRelative (related person)ResearchRewardsRiskRisk BehaviorsRisk-TakingSignal TransductionStimulusTeenagersTestingTimeTranslatingUnsafe Sexadolescent drug useage differenceage groupage relatedblood oxygenation level dependent responsedesigneffective interventioninterestneurodevelopmentprogramspublic health relevancereinforcerrelating to nervous systemresponse
项目摘要
DESCRIPTION (provided by applicant): Adolescence is a risk period for the onset of drug use, with more individuals initiating drug use during these years than any other time in life. In addition, those individuals who initiate drug use earlier in adolescence are at greater risk for developing drug abuse and dependence later in life. Adolescents are known to engage disproportionately in many types of risky behavior, such as reckless driving, illicit drug use, and
unsafe sex. Research has aimed to determine whether the development of neural processing could lead to the post- adolescent drop in risk-taking behavior. While several studies have demonstrated shifts in reward sensitivity across adolescence, very little research has examined the development of sensitivity to punishment. Recent research has demonstrated behaviorally that the ability to learn from punishment continues to develop throughout adolescence. It is unclear, however, if this is because children and adolescents simply find negative events less aversive than adults, or if, instead, they find punishment equally unpleasant, but are unable to incorporate this information into a learning signal, known as a prediction error signal, that is necessary to learn to approach or avoid stimuli that have previously been rewarded or punished, respectively. The proposed study aims to dissociate between these two possibilities by having groups of children, adolescents, and young adults perform a valence-modulated probabilistic learning task in an MRI scanner, where they be rewarded for correct choices during one block, and punished for incorrect choices during another. BOLD response will be measured in a contrast of negative feedback vs. positive feedback and compared across age groups to determine developmental differences in overall response to punishment, and separately prediction error response to punishment will be measured. We predict that no age differences will emerge in the negative feedback vs. positive feedback contrast, but children and adolescents will show a diminished prediction error response relative to adults.
描述(由申请人提供):青春期是开始使用药物的风险期,在这几年中开始使用药物的人比生命中的任何其他时间都多。此外,那些在青春期较早开始吸毒的人在以后的生活中出现药物滥用和依赖的风险更大。众所周知,青少年不成比例地从事许多类型的危险行为,如鲁莽驾驶,非法使用毒品,
不安全性行为研究旨在确定神经处理的发展是否会导致青春期后冒险行为的减少。虽然一些研究已经证明了青少年时期奖励敏感性的变化,但很少有研究探讨对惩罚敏感性的发展。最近的研究表明,从惩罚中学习的能力在整个青春期都在不断发展。然而,目前尚不清楚这是因为儿童和青少年只是觉得负面事件不如成年人那么令人厌恶,还是因为他们觉得惩罚同样令人不快,但无法将这些信息纳入学习信号,称为预测错误信号,这是学习接近或避免先前分别受到奖励或惩罚的刺激所必需的。这项研究的目的是通过让一组儿童、青少年和年轻人在MRI扫描仪中执行一个价调制概率学习任务来分离这两种可能性,在这个任务中,他们在一个区块中做出正确的选择而受到奖励,在另一个区块中做出不正确的选择而受到惩罚。BOLD反应将在负反馈与正反馈的对比中进行测量,并在不同年龄组之间进行比较,以确定对惩罚的总体反应的发展差异,并将单独测量对惩罚的预测错误反应。我们预测,在负反馈与正反馈的对比中不会出现年龄差异,但儿童和青少年的预测错误反应相对于成年人会有所减少。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Russell A Poldrack其他文献
Making big data open: data sharing in neuroimaging
开放大数据:神经影像学中的数据共享
- DOI:
10.1038/nn.3818 - 发表时间:
2014-10-28 - 期刊:
- 影响因子:20.000
- 作者:
Russell A Poldrack;Krzysztof J Gorgolewski - 通讯作者:
Krzysztof J Gorgolewski
The young and the reckless
年轻而鲁莽的人
- DOI:
10.1038/nn.3116 - 发表时间:
2012-05-25 - 期刊:
- 影响因子:20.000
- 作者:
Sarah M Helfinstein;Russell A Poldrack - 通讯作者:
Russell A Poldrack
Russell A Poldrack的其他文献
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{{ truncateString('Russell A Poldrack', 18)}}的其他基金
Data-driven validation of cognitive RDoC dimensions using deep phenotyping
使用深度表型分析对认知 RDoC 维度进行数据驱动验证
- 批准号:
10686101 - 财政年份:2022
- 资助金额:
$ 37.93万 - 项目类别:
Data-driven validation of cognitive RDoC dimensions using deep phenotyping
使用深度表型分析对认知 RDoC 维度进行数据驱动验证
- 批准号:
10515980 - 财政年份:2022
- 资助金额:
$ 37.93万 - 项目类别:
NIPreps: integrating neuroimaging preprocessing workflows across modalities, populations, and species
NIPreps:整合跨模式、人群和物种的神经影像预处理工作流程
- 批准号:
10513258 - 财政年份:2021
- 资助金额:
$ 37.93万 - 项目类别:
Characterizing cognitive control networks using a precision neuroscience approach
使用精确神经科学方法表征认知控制网络
- 批准号:
9906911 - 财政年份:2018
- 资助金额:
$ 37.93万 - 项目类别:
OpenNeuro: An open archive for analysis and sharing of BRAIN Initiative data
OpenNeuro:用于分析和共享 BRAIN Initiative 数据的开放档案
- 批准号:
10365039 - 财政年份:2018
- 资助金额:
$ 37.93万 - 项目类别:
OpenNeuro: An open archive for analysis and sharing of BRAIN Initiative data
OpenNeuro:用于分析和共享 BRAIN Initiative 数据的开放档案
- 批准号:
10417031 - 财政年份:2018
- 资助金额:
$ 37.93万 - 项目类别:
OpenNeuro: An open archive for analysis and sharing of BRAIN Initiative data
OpenNeuro:用于分析和共享 BRAIN Initiative 数据的开放档案
- 批准号:
10451257 - 财政年份:2018
- 资助金额:
$ 37.93万 - 项目类别:
Characterizing cognitive control networks using a precision neuroscience approach
使用精确神经科学方法表征认知控制网络
- 批准号:
10398085 - 财政年份:2018
- 资助金额:
$ 37.93万 - 项目类别:
BIDS-Derivatives: A data standard for derived data and models in the BRAIN Initiative
BIDS-Derivatives:BRAIN Initiative 中派生数据和模型的数据标准
- 批准号:
9411944 - 财政年份:2017
- 资助金额:
$ 37.93万 - 项目类别:
The development of neural responses to punishment in adolescence
青春期对惩罚的神经反应的发展
- 批准号:
8699087 - 财政年份:2013
- 资助金额:
$ 37.93万 - 项目类别:
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