Device for Measuring Capillary Blood Flow and the Onset of Shock
测量毛细血管血流量和休克发生的装置
基本信息
- 批准号:8646183
- 负责人:
- 金额:$ 49.74万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2011
- 资助国家:美国
- 起止时间:2011-09-06 至 2016-05-31
- 项目状态:已结题
- 来源:
- 关键词:Accident and Emergency departmentAcetyleneAlgorithmsBloodBlood CellsBlood Flow VelocityBlood PressureBlood capillariesBlood flowCardiac OutputCardiovascular systemCause of DeathCessation of lifeCharacteristicsClinicClinicalCollaborationsCritical CareDataDevelopmentDevicesDiffuseFailureFamily suidaeFundingGoalsHealthHeart RateHemorrhageHemorrhagic ShockHospitalsHourHumanHypoxiaLeadLearningLifeLightingLower Body Negative PressureMeasurementMeasuresMethodsMilitary PersonnelModelingMonitorMotionOperative Surgical ProceduresOpticsOrganOrgan failurePatientsPerfusionPhasePhysiologic MonitoringPhysiologicalPredictive ValuePresyncopesPropertyProtocols documentationPulse PressureRadiation MonitoringReportingSepsisShockSkinSpectrum AnalysisSpinalStroke VolumeSystemTestingTimeTissuesTraumaUltrasonographyVariantWorkabsorptionbasecapillarycapillary beddesignheart rate variabilityimprovedinstrumentlight scatteringmeetingsmonitoring devicemortalityperipheral bloodpressureprogramsresearch clinical testingsensortrauma centersuptakevolunteer
项目摘要
DESCRIPTION (provided by applicant): Hemorrhagic shock is a major cause of death in emergency departments and trauma centers. Currently there is no clinically accepted quantitative monitor of the onset of hemorrhagic shock. Death from hemorrhagic shock results from diminished capillary blood flow and the resultant failure of the body to oxygenate major organs. The long-term goal of this proposal, a collaboration between Radiation Monitoring Devices and the Mayo Clinic, is to develop a sensor patch (CBFM) that attaches to a patient's skin and continuously monitors capillary blood flow and predicts the onset of hemorrhagic shock. The sensor is based upon diffuse correlation spectroscopy (DCS). DCS measures fluctuations in near-infrared light scattering of blood cell motion in capillaries. DCS extracts th characteristic time constants due to mean blood flow velocity. The aims of the proposal are: 1. Integrate DCS system with physiological monitors, 2. Perform definitive measurements using the human lower body negative pressure (LBNP) model for hemorrhage. 3. Analyze DCS and physiological data and answer the following questions: Is normalization of subject-to-subject variation possible? Is subject-to-subject variability reduced by DRS-based determination of tissue scattering and absorbance properties? Is predictive value improved by addition of vital parameters and if so, what is the "best" approach to multiparametric "smart" algorithms? Is predictive value improved by measuring the change in τ with progressive bleed? 4. Perform LBNP studies under the US Army LBNP pressure to failure (presyncope) protocol. 5. Test the CBFM in a clinical setting during high-blood loss, human spinal surgery. 6. Complete all reports
描述(申请人提供):失血性休克是急诊科和创伤中心的主要死亡原因。目前尚无临床公认的失血性休克发病的定量监测方法。失血性休克死亡的原因是毛细血管血流量减少,导致身体不能给主要器官供氧。这项由辐射监测设备公司和梅奥诊所合作的计划的长期目标是开发一种传感器贴片(CBFM),这种贴片可以附着在患者的皮肤上,持续监测毛细血管血流,并预测失血性休克的发生。该传感器是基于漫相关光谱分析的。分布式控制系统测量毛细血管中血细胞运动的近红外光散射的波动。由于平均血流速度的原因,DCSTH提取特征时间常数。该方案的目的是:1.将集散控制系统与生理监护仪相结合,2.使用人体下体负压(LBNP)模型对出血进行明确的测量。3.分析DCs和生理数据,并回答以下问题:受试者与受试者之间的变异是否可能正常化?基于DRS的组织散射和吸光度特性的测定是否降低了受试者之间的可变性?是否通过添加重要参数来提高预测价值?如果是,多参数“智能”算法的“最佳”方法是什么?通过测量伴有进行性出血的下体负压的变化是否提高了预测价值?4.根据美国陆军下体负压至失败(晕厥前)方案进行下体负压研究。5.在高失血量的人类脊柱手术期间,在临床环境中测试CBFM。6.填写所有报告
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
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JAMES F CHRISTIAN其他文献
JAMES F CHRISTIAN的其他文献
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