Integrated Molecular and Cellular Immunology Core

综合分子和细胞免疫学核心

• 批准号: 8705988
• 负责人: Leslie S Kean
• 金额: $ 22.6万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-01 至 2017-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8705988
• 关键词: Address; Autopsy; B-Lymphocytes; Biological Assay; Biopsy; Cell Separation; Cell physiology; Cellular Immunology; Chronic; Clinic; Collaborations; Complex; Computer software; DNA; Data Set; Development; Elements; End stage renal failure; Ensure; Face; Flow Cytometry; Histopathology; Homologous Gene; Human Herpesvirus 4; Immune Tolerance; Immune response; Immunity; Immunogenetics; Immunologic Markers; Immunologic Monitoring; Immunosuppression; Information Management; Instruction; Intervention; Kidney; Kidney Transplantation; Latent Virus; Macaca mulatta; Methodology; Molecular; Molecular Analysis; Molecular Immunology; Molecular Virology; Monitor; Organ; Outcome; Patients; Polyomavirus; Procedures; Publishing; RNA; Regimen; Reproducibility; Research; Research Personnel; Risk; Safety; Sampling; Services; Simian virus 40; System; T-Lymphocyte; Technology; Toxic effect; Translating; Transplant Recipients; Transplantation; Transplantation Tolerance; Viral; base; biobank; clinically relevant; data management; design; improved; member; nonhuman primate; novel; research study; tool

PROJECT SUMMARY (See instructions): The Molecular and Cellular Immunology Core: The Emory Transplant Center and this Consortium benefits from an integrated approach to performing nonhuman primate (NHP) transplant tolerance research. The hub of this integration is the integrated Molecular and Cellular Immunology Core (MClC), which coordinates and streamlines all common assays and procedures, as well as the NHP procurement and typing needs for all members of the ETC. The MClC is comprised of five interacting elements: (1) The MHC Immunogenetics and Typing Core. (2) The Flow Cytometry Core. (3) The NHP Histopathology Core. (4) The Molecular Immunology and Virology Core and (5) The Functional Protective Immunity Core. Each Core addresses a critical need for the conduct of the complex experiments that are proposed in each of the projects and promotes collaboration between investigators. As such, the development of these integrated services has significantly increased the efficiency and the rigor with which our group is able to execute complex NHP transplantation tolerance research.

项目总结（见说明）： 分子和细胞免疫学核心： 埃默里移植中心和这个联盟受益于一个综合的方法来执行非人灵长类动物（NHP）移植耐受性研究。这种整合的中心是整合的分子和细胞免疫学核心（MCLC），其协调和简化所有常见的测定和程序，以及ETC所有成员的NHP采购和分型需求。MCLC由五个相互作用的元素组成：（1）MHC免疫遗传学和分型核心。(2)流式细胞术核心。(3)NHP历史学核心。(4)分子免疫学和病毒学核心和（5）功能保护性免疫核心。每个核心都解决了每个项目中提出的复杂实验的关键需求，并促进了研究人员之间的合作。因此，这些综合服务的发展显着提高了效率和严谨性，我们的团队能够执行复杂的NHP移植耐受性研究。